СПИСОК ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> Monsanto Technology LLC Bowen, David J Catherine, Chay A Todd, Ciche A Uma, Kesanapalli R Jennifer, Lutke L <120> НОВЫЕ БЕЛКИ, ПРОЯВЛЯЮЩИЕ ИНГИБИРУЮЩУЮ АКТИВНОСТЬ ПО ОТНОШЕНИЮ К НАСЕКОМЫМ <130> 38-21(61627)-0001 <150> США 62/210,737 <151> 2015-08-27 <160> 18 <170> PatentIn версия 3.5 <210> 1 <211> 2394 <212> ДНК <213> Paenibacillus popilliae <220> <221> прочий_признак <222> (1)..(2394) <223> Последовательность ДНК, полученная из штамма DSC004343 Paenibacillus popilliae, кодирующая TIC6757. <400> 1 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 60 ggaatttatg gttttgccac tggcattcaa gatattttta acatgatttt tggaacagat 120 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 180 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 240 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 300 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 360 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 420 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 480 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 540 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 600 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 660 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 720 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 780 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 840 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 900 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 960 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1020 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1080 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1140 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1200 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1260 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1320 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1380 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1440 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1500 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1560 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1620 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1680 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1740 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1800 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1860 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1920 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 1980 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2040 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2100 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2160 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2220 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattagt 2280 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2340 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga ataa 2394 <210> 2 <211> 797 <212> ПРТ <213> Paenibacillus popilliae <220> <221> ПРОЧИЙ_ПРИЗНАК <222> (1)..(797) <223> Аминокислотная последовательность TIC6757, полученная из кодирующей последовательности штамма DSC004343 Paenibacillus popilliae, кодирующая TIC6757. <400> 2 Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe Ile 1 5 10 15 Asp Val Phe Asn Gly Ile Tyr Gly Phe Ala Thr Gly Ile Gln Asp Ile 20 25 30 Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu Glu 35 40 45 Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu Glu 50 55 60 Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu Asn 65 70 75 80 Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn Asn 85 90 95 Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met Leu 100 105 110 His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met Lys 115 120 125 Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln Leu 130 135 140 Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu Ile 145 150 155 160 Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr 165 170 175 Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr Leu 180 185 190 Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu Glu 195 200 205 Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 210 215 220 Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu Ile 225 230 235 240 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu Leu 245 250 255 Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys Val 260 265 270 Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe Leu 275 280 285 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp Tyr 290 295 300 Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe Arg 305 310 315 320 Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn Tyr 325 330 335 Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu Ala 340 345 350 Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg Ile 355 360 365 Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln Val 370 375 380 Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys Leu 385 390 395 400 Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu Thr 405 410 415 Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys Leu 420 425 430 Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser Thr 435 440 445 Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu Gln 450 455 460 Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr Met 465 470 475 480 Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser Phe 485 490 495 Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys Lys 500 505 510 Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys Glu 515 520 525 Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val Glu 530 535 540 Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn Asn 545 550 555 560 Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys Ala 565 570 575 Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp Lys 580 585 590 Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly Lys 595 600 605 Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr Glu 610 615 620 Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn Tyr 625 630 635 640 Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser Gln 645 650 655 Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys Lys 660 665 670 Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp Trp 675 680 685 Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile Asp 690 695 700 Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser Tyr 705 710 715 720 Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys Val 725 730 735 Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser Gln 740 745 750 Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr Thr Thr Ser Asn 755 760 765 Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly Phe 770 775 780 Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795 <210> 3 <211> 2397 <212> ДНК <213> Искусственная <220> <223> Синтетическая последовательность ДНК, сконструированная для экспрессии в растении, кодирующая TIC6757PL с дополнительным остатком аланина, встроенным в положении 2 относительно аминокислотной последовательности бактериального TIC6757, полученного из штамма DSC004343 Paenibacillus popilliae, кодирующего TIC6757. <400> 3 atggctaagc agaacaacaa cttctccgtg cgcgcgctcc cgtcgttcat cgacgtcttc 60 aacggcatct acgggttcgc caccggcatc caggacatct tcaacatgat cttcggcacc 120 gacacgggcg acctcacgct ggaggaggtg ctcaagaacc aggaactgct ctacgacatc 180 tcgggcaagc tggagggcat ctccggcgac ctcagcgaaa ttatcgcgca agggaacctc 240 aacacggagc tggcgaaaga gctgctcaag atcgccaacg agcagaacaa cgtgctgacg 300 gacgtgaaca acaagctcaa cgcgatcaac tcgatgctcc acatctacct cccaaagatt 360 acgaacatgc tgtccgacgt catgaagcag aactatgccc tcagcctcca gatcgagtac 420 ctctcgaagc agctccagga gatttcggat aagctggacg tcatcaacct gaacgtgctg 480 ataaactcca cgctcacgga gatcactccg gcctaccagc gcatcaagta cgtgaacgag 540 aagttcgacg agctgacact ggcgactgag aagaccctcc gcgccaagca agggtccgag 600 gacatcattg cgaacgacac gctggagaac ttgacggagt tgaccgagct ggccaagagc 660 gtgacgaaga acgacatgga cagcttcgag ttctacctcc acactttcca cgacgtgctg 720 atcggcaaca acctcttcgg ccggagcgcg ctcaagaccg cagccgagct gattacgaag 780 gacgagatca agacctccgg gtccgagatc ggaaaggtgt acagcttcct gatcgtcctc 840 acgtgcttac aagctaaggc gttcctcacc ctgaccgcct gccgtaagct gttgggcctg 900 tccgacatcg actacaccaa catcctcaac cagcacctca acgacgagaa gaacgtcttt 960 cgggacaaca tcctcccgac actgagcaac aagttcagta acccgaacta cgtcaagacg 1020 attggcagcg acaactacgc caaggttatc ctagaggccg agcccggtta cgccctggtc 1080 gggttcgaga tcatcaacga ccgcatcccg gtcctcaagg cgtacaaggc caagctcaag 1140 cagaactacc aagtggacca ccagagcctc agcgagatcg tgtacctgga catcgacaag 1200 ttgttctgcc cgaagaactc ggagcagaag tattacacca agagcctgac cttcccggac 1260 ggctacgtta ttacaaagat cacgttcgag aagaagctca acaacctccg ttacgaggca 1320 actgccaact tctacgaccc gtccaccggc gacattgact tgaacgagaa gcaagtcgag 1380 tccacgttcc tccaggccga ctacatcagc atcaacgtca gcgacgacga cggcgtgtac 1440 atgccgctcg gagtcatcag cgagaccttc ctcagcccga tcaactcgtt cgagctggag 1500 gtggacgaga agtccaagat tctcaccctg acctgcaaga gctacctccg ggaatacctc 1560 ctggagagcg acctcatcaa taaggagact tcgctcatag ctccgcccaa cgtcttcatc 1620 tccaacatcg tcgagaactg gaacatcgag gccgacaacc tggagccgtg ggtggcaaac 1680 aacaagaacg cctacgtgga ctccaccggc gggatcgagg gaagcaaggc cctgttcacc 1740 cagggcgacg gtgagttctc gcagttcatc ggcgacaagc tcaagcccaa cacggactac 1800 atcatccagt acaccgtcaa gggcaagcca gcgatctacc tcaagaacaa gaacaccggg 1860 tacaccatgt acgaggacac gaacggcagc agcgaggagt tccagaccat cgcggtcaac 1920 tacacctccg agaccgatcc ctcccagacc caccttgtct tcaagtccca gagcggctac 1980 gaggcgtggg gcgacaactt catcatcctg gagtgcaagg ctttcgagac tcccgagggc 2040 ccggagctta tcaagttcga tgactggatt tcgtttggca ccacctacat ccgggacgac 2100 gtgctaacca tcgacccgtc gcgcggcggc tacttccgcc aaagcctcaa gctggactcg 2160 tactccacgt acaacctatc tttcagcttc tcgggcctgt gggcgaaggt gattatcaag 2220 aactcgcacg gcgtggtcct gttcgagaag gtctcccagc agtcgtcata cgtggacatc 2280 agcgagtcct tcaccaccac cagcaacaag gagggcttct tcatcgagct gaccggcgac 2340 tcgcgcggcg ggttcggctc cttccgcgac ttctccatga aggagaaatt cgagtga 2397 <210> 4 <211> 798 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность TIC6757PL, кодируемая синтетической последовательностью ДНК, при этом дополнительный остаток аланина встроен в положении 2 по отношению к бактериальной аминокислотной последовательности TIC6757 <400> 4 Met Ala Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe 1 5 10 15 Ile Asp Val Phe Asn Gly Ile Tyr Gly Phe Ala Thr Gly Ile Gln Asp 20 25 30 Ile Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu 35 40 45 Glu Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu 50 55 60 Glu Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu 65 70 75 80 Asn Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn 85 90 95 Asn Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met 100 105 110 Leu His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met 115 120 125 Lys Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln 130 135 140 Leu Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu 145 150 155 160 Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys 165 170 175 Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr 180 185 190 Leu Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu 195 200 205 Glu Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn 210 215 220 Asp Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu 225 230 235 240 Ile Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu 245 250 255 Leu Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys 260 265 270 Val Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe 275 280 285 Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp 290 295 300 Tyr Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe 305 310 315 320 Arg Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn 325 330 335 Tyr Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu 340 345 350 Ala Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg 355 360 365 Ile Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln 370 375 380 Val Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys 385 390 395 400 Leu Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu 405 410 415 Thr Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys 420 425 430 Leu Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser 435 440 445 Thr Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu 450 455 460 Gln Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr 465 470 475 480 Met Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser 485 490 495 Phe Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys 500 505 510 Lys Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys 515 520 525 Glu Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val 530 535 540 Glu Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn 545 550 555 560 Asn Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys 565 570 575 Ala Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp 580 585 590 Lys Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly 595 600 605 Lys Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr 610 615 620 Glu Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn 625 630 635 640 Tyr Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser 645 650 655 Gln Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys 660 665 670 Lys Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp 675 680 685 Trp Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile 690 695 700 Asp Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser 705 710 715 720 Tyr Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys 725 730 735 Val Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser 740 745 750 Gln Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr Thr Thr Ser 755 760 765 Asn Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly 770 775 780 Phe Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795 <210> 5 <211> 2454 <212> ДНК <213> Искусственная <220> <223> Рекомбинантная последовательность нуклеиновой кислоты, кодирующая белок TIC6757, меченный гистидином. <400> 5 atgcatcacc atcaccatca ccatcaccat cacggtaccg agaccgtccg cttccaatcc 60 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 120 ggaatttatg gttttgccac tggcattcaa gatattttta acatgatttt tggaacagat 180 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 240 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 300 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 360 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 420 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 480 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 540 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 600 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 660 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 720 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 780 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 840 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 900 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 960 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 1020 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1080 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1140 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1200 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1260 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1320 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1380 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1440 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1500 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1560 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1620 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1680 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1740 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1800 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1860 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1920 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1980 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 2040 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2100 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2160 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2220 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2280 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattagt 2340 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2400 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga ataa 2454 <210> 6 <211> 817 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность меченного гистидином белка TIC6757. <400> 6 Met His His His His His His His His His His Gly Thr Glu Thr Val 1 5 10 15 Arg Phe Gln Ser Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu 20 25 30 Pro Ser Phe Ile Asp Val Phe Asn Gly Ile Tyr Gly Phe Ala Thr Gly 35 40 45 Ile Gln Asp Ile Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu 50 55 60 Thr Leu Glu Glu Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser 65 70 75 80 Gly Lys Leu Glu Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln 85 90 95 Gly Asn Leu Asn Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn 100 105 110 Glu Gln Asn Asn Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile 115 120 125 Asn Ser Met Leu His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser 130 135 140 Asp Val Met Lys Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu 145 150 155 160 Ser Lys Gln Leu Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu 165 170 175 Asn Val Leu Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln 180 185 190 Arg Ile Lys Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr 195 200 205 Glu Lys Thr Leu Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn 210 215 220 Asp Thr Leu Glu Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val 225 230 235 240 Thr Lys Asn Asp Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His 245 250 255 Asp Val Leu Ile Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr 260 265 270 Ala Ala Glu Leu Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu 275 280 285 Ile Gly Lys Val Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala 290 295 300 Lys Ala Phe Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser 305 310 315 320 Asp Ile Asp Tyr Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys 325 330 335 Asn Val Phe Arg Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser 340 345 350 Asn Pro Asn Tyr Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val 355 360 365 Ile Leu Glu Ala Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile 370 375 380 Asn Asp Arg Ile Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln 385 390 395 400 Asn Tyr Gln Val Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp 405 410 415 Ile Asp Lys Leu Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr 420 425 430 Lys Ser Leu Thr Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe 435 440 445 Glu Lys Lys Leu Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr 450 455 460 Asp Pro Ser Thr Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser 465 470 475 480 Thr Phe Leu Gln Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp 485 490 495 Gly Val Tyr Met Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro 500 505 510 Ile Asn Ser Phe Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr 515 520 525 Leu Thr Cys Lys Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu 530 535 540 Ile Asn Lys Glu Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser 545 550 555 560 Asn Ile Val Glu Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp 565 570 575 Val Ala Asn Asn Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu 580 585 590 Gly Ser Lys Ala Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe 595 600 605 Ile Gly Asp Lys Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr 610 615 620 Val Lys Gly Lys Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr 625 630 635 640 Thr Met Tyr Glu Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile 645 650 655 Ala Val Asn Tyr Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val 660 665 670 Phe Lys Ser Gln Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile 675 680 685 Leu Glu Cys Lys Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys 690 695 700 Phe Asp Asp Trp Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val 705 710 715 720 Leu Thr Ile Asp Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys 725 730 735 Leu Asp Ser Tyr Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu 740 745 750 Trp Ala Lys Val Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu 755 760 765 Lys Val Ser Gln Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr 770 775 780 Thr Thr Ser Asn Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser 785 790 795 800 Arg Gly Gly Phe Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe 805 810 815 Glu <210> 7 <211> 2394 <212> ДНК <213> Paenibacillus popilliae <220> <221> прочий_признак <222> (1)..(2394) <223> Последовательность ДНК, полученная из штамма DSC007648 Paenibacillus popilliae, кодирующая TIC7472. <400> 7 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 60 ggaatttatg attttgccac tggcattcaa gatattttta acatgatttt tggaacagat 120 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 180 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 240 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 300 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 360 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 420 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 480 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 540 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 600 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 660 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 720 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 780 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 840 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 900 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 960 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1020 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1080 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1140 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1200 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1260 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1320 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1380 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1440 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1500 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1560 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1620 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1680 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1740 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1800 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1860 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1920 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 1980 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2040 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2100 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2160 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2220 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattaat 2280 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2340 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga ataa 2394 <210> 8 <211> 797 <212> ПРТ <213> Paenibacillus popilliae <220> <221> ПРОЧИЙ_ПРИЗНАК <222> (1)..(797) <223> Аминокислотная последовательность TIC7472, полученная из кодирующей последовательности штамма DSC007648 Paenibacillus popilliae, которая кодирует TIC7472. <400> 8 Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe Ile 1 5 10 15 Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp Ile 20 25 30 Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu Glu 35 40 45 Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu Glu 50 55 60 Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu Asn 65 70 75 80 Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn Asn 85 90 95 Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met Leu 100 105 110 His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met Lys 115 120 125 Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln Leu 130 135 140 Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu Ile 145 150 155 160 Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr 165 170 175 Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr Leu 180 185 190 Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu Glu 195 200 205 Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 210 215 220 Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu Ile 225 230 235 240 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu Leu 245 250 255 Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys Val 260 265 270 Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe Leu 275 280 285 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp Tyr 290 295 300 Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe Arg 305 310 315 320 Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn Tyr 325 330 335 Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu Ala 340 345 350 Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg Ile 355 360 365 Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln Val 370 375 380 Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys Leu 385 390 395 400 Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu Thr 405 410 415 Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys Leu 420 425 430 Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser Thr 435 440 445 Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu Gln 450 455 460 Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr Met 465 470 475 480 Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser Phe 485 490 495 Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys Lys 500 505 510 Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys Glu 515 520 525 Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val Glu 530 535 540 Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn Asn 545 550 555 560 Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys Ala 565 570 575 Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp Lys 580 585 590 Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly Lys 595 600 605 Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr Glu 610 615 620 Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn Tyr 625 630 635 640 Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser Gln 645 650 655 Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys Lys 660 665 670 Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp Trp 675 680 685 Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile Asp 690 695 700 Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser Tyr 705 710 715 720 Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys Val 725 730 735 Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser Gln 740 745 750 Gln Ser Ser Tyr Val Asp Ile Asn Glu Ser Phe Thr Thr Thr Ser Asn 755 760 765 Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly Phe 770 775 780 Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795 <210> 9 <211> 2418 <212> ДНК <213> Искусственная <220> <223> Рекомбинантная последовательность нуклеиновой кислоты, кодирующая белок TIC7472, меченный гистидином. <400> 9 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 60 ggaatttatg attttgccac tggcattcaa gatattttta acatgatttt tggaacagat 120 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 180 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 240 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 300 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 360 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 420 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 480 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 540 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 600 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 660 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 720 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 780 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 840 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 900 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 960 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1020 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1080 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1140 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1200 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1260 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1320 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1380 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1440 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1500 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1560 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1620 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1680 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1740 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1800 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1860 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1920 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 1980 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2040 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2100 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2160 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2220 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattaat 2280 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2340 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga acaccaccat 2400 cacgctcacc atcactga 2418 <210> 10 <211> 805 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность меченного гистидином белка TIC747. <400> 10 Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe Ile 1 5 10 15 Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp Ile 20 25 30 Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu Glu 35 40 45 Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu Glu 50 55 60 Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu Asn 65 70 75 80 Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn Asn 85 90 95 Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met Leu 100 105 110 His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met Lys 115 120 125 Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln Leu 130 135 140 Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu Ile 145 150 155 160 Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr 165 170 175 Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr Leu 180 185 190 Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu Glu 195 200 205 Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 210 215 220 Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu Ile 225 230 235 240 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu Leu 245 250 255 Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys Val 260 265 270 Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe Leu 275 280 285 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp Tyr 290 295 300 Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe Arg 305 310 315 320 Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn Tyr 325 330 335 Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu Ala 340 345 350 Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg Ile 355 360 365 Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln Val 370 375 380 Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys Leu 385 390 395 400 Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu Thr 405 410 415 Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys Leu 420 425 430 Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser Thr 435 440 445 Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu Gln 450 455 460 Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr Met 465 470 475 480 Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser Phe 485 490 495 Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys Lys 500 505 510 Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys Glu 515 520 525 Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val Glu 530 535 540 Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn Asn 545 550 555 560 Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys Ala 565 570 575 Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp Lys 580 585 590 Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly Lys 595 600 605 Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr Glu 610 615 620 Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn Tyr 625 630 635 640 Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser Gln 645 650 655 Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys Lys 660 665 670 Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp Trp 675 680 685 Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile Asp 690 695 700 Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser Tyr 705 710 715 720 Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys Val 725 730 735 Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser Gln 740 745 750 Gln Ser Ser Tyr Val Asp Ile Asn Glu Ser Phe Thr Thr Thr Ser Asn 755 760 765 Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly Phe 770 775 780 Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu His His His 785 790 795 800 His Ala His His His 805 <210> 11 <211> 2394 <212> ДНК <213> Paenibacillus popilliae <220> <221> прочий_признак <222> (1)..(2394) <223> Последовательность ДНК, полученная из штамма DSC008493 Paenibacillus popilliae, кодирующая TIC7473. <400> 11 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 60 ggaatttatg attttgccac tggcattcaa gatattttta acatgatttt tggaacagat 120 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 180 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 240 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 300 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 360 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 420 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 480 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 540 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 600 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 660 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 720 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 780 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 840 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 900 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 960 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1020 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1080 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1140 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1200 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1260 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1320 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1380 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1440 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1500 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1560 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1620 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1680 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1740 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1800 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1860 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1920 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 1980 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2040 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2100 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2160 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2220 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattagt 2280 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2340 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga ataa 2394 <210> 12 <211> 797 <212> ПРТ <213> Paenibacillus popilliae <220> <221> ПРОЧИЙ_ПРИЗНАК <222> (1)..(797) <223> Аминокислотная последовательность TIC7473 полученная из кодирующей последовательности штамма DSC008493 Paenibacillus, которая кодирует TIC7473. <400> 12 Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe Ile 1 5 10 15 Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp Ile 20 25 30 Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu Glu 35 40 45 Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu Glu 50 55 60 Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu Asn 65 70 75 80 Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn Asn 85 90 95 Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met Leu 100 105 110 His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met Lys 115 120 125 Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln Leu 130 135 140 Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu Ile 145 150 155 160 Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr 165 170 175 Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr Leu 180 185 190 Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu Glu 195 200 205 Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 210 215 220 Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu Ile 225 230 235 240 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu Leu 245 250 255 Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys Val 260 265 270 Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe Leu 275 280 285 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp Tyr 290 295 300 Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe Arg 305 310 315 320 Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn Tyr 325 330 335 Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu Ala 340 345 350 Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg Ile 355 360 365 Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln Val 370 375 380 Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys Leu 385 390 395 400 Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu Thr 405 410 415 Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys Leu 420 425 430 Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser Thr 435 440 445 Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu Gln 450 455 460 Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr Met 465 470 475 480 Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser Phe 485 490 495 Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys Lys 500 505 510 Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys Glu 515 520 525 Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val Glu 530 535 540 Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn Asn 545 550 555 560 Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys Ala 565 570 575 Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp Lys 580 585 590 Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly Lys 595 600 605 Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr Glu 610 615 620 Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn Tyr 625 630 635 640 Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser Gln 645 650 655 Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys Lys 660 665 670 Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp Trp 675 680 685 Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile Asp 690 695 700 Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser Tyr 705 710 715 720 Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys Val 725 730 735 Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser Gln 740 745 750 Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr Thr Thr Ser Asn 755 760 765 Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly Phe 770 775 780 Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795 <210> 13 <211> 2418 <212> ДНК <213> Искусственная <220> <223> Рекомбинантная последовательность нуклеиновой кислоты, кодирующая белок TIC7473, меченный гистидином. <400> 13 atgaagcaga ataataattt tagtgtaagg gccttaccaa gttttattga tgtttttaat 60 ggaatttatg attttgccac tggcattcaa gatattttta acatgatttt tggaacagat 120 acaggtgatc taacactaga agaagtttta aaaaatcaag agttacttta tgatatttct 180 ggtaaacttg aggggattag tggagaccta agtgagatta ttgcgcaggg aaatttgaat 240 acagaattag ctaaggaatt gctaaaaatc gctaatgagc agaacaacgt attaactgat 300 gttaataaca aactcaatgc gataaattcg atgctccaca tctatcttcc taaaattaca 360 aatatgttaa gcgatgttat gaaacagaat tatgctctga gtcttcaaat agaatatctc 420 agtaaacaac tacaggagat atcagataaa cttgatgtta ttaacttaaa tgtactcatt 480 aactctacac tcacagaaat cactcctgct tatcaacgta ttaaatatgt aaatgaaaaa 540 tttgatgaat taactcttgc tacagaaaaa actctaagag caaaacaagg tagcgaagac 600 attattgcta atgatactct tgaaaattta actgagctaa cagaactagc gaaaagtgta 660 acaaaaaatg acatggatag tttcgagttt tatctccata cattccatga tgtattgatt 720 ggcaataatt tatttggtcg ttcggcttta aaaacagctg cagaattgat tactaaagac 780 gagataaaga cgagtggaag tgagatagga aaagtttata gtttcttaat tgtactaact 840 tgtctacaag caaaagcctt tctcacttta acggcatgcc gaaaattatt gggcttatca 900 gatattgatt atactaatat tctaaatcag catctaaatg atgaaaagaa tgtatttcgt 960 gataacatac ttcctacact gtccaataaa ttttctaacc ctaattatgt aaaaactata 1020 ggtagtgata attatgcaaa agttatttta gaagctgaac caggatatgc tttagttgga 1080 tttgaaatta tcaatgatcg aatcccggta ttaaaagcgt ataaagctaa gctaaaacaa 1140 aattatcaag ttgatcatca gtcgttatca gagattgttt atttagatat cgataaacta 1200 ttttgtccaa aaaattctga acaaaaatat tatactaaaa gtctgacatt tcctgatggc 1260 tatgttatta ctaagattac ctttgaaaaa aagctgaaca acctaagata tgaggcaaca 1320 gcaaattttt atgacccatc tacaggagat attgatttaa atgagaagca agtggaatct 1380 acttttcttc aagcagatta tatttctata aatgttagtg atgatgatgg tgtttacatg 1440 ccgttaggcg ttatcagcga aacatttttg tctccaatta atagttttga attagaagtt 1500 gacgagaaat cgaaaatctt aactttaaca tgtaaatctt atttacgaga atatttatta 1560 gaatctgatt taataaataa agagacaagc ctcattgctc cgcctaatgt ttttatcagt 1620 aatatcgtag aaaattggaa catagaagcg gataatctag aaccatgggt agcaaataac 1680 aagaatgcat atgtcgatag tacaggcggc atagagggat ctaaagctct atttactcaa 1740 ggtgatgggg aattttcaca atttattgga gataaattaa aaccaaatac agattatatt 1800 attcaatata ctgtaaaagg aaaacctgct atttatttaa aaaacaaaaa tactggatat 1860 actatgtacg aagatacaaa cggtagttct gaagaatttc aaactatagc tgtaaattat 1920 acttcagaaa ctgatccttc acaaacacat ttagttttta aaagtcaaag tggctatgag 1980 gcttgggggg acaactttat tattctagaa tgtaaggcat ttgaaactcc agaaggtcca 2040 gaattgataa aatttgatga ttggattagt tttggtacta cttacattag agatgatgta 2100 cttactatcg atccaagtcg tggaggttat tttagacaat ctcttaaatt agacagctat 2160 tcaacttata atttgagctt ttctttttct ggattatggg ctaaggttat tataaaaaat 2220 tcccacggag tagtattgtt tgaaaaagta agtcagcagt cttcatacgt agatattagt 2280 gaaagtttta ctaccacatc aaataaagaa ggatttttta tagaactaac gggcgatagt 2340 cgtggtggtt ttgggtcgtt ccgtgatttt tctatgaagg aaaagtttga acaccaccat 2400 cacgctcacc atcactga 2418 <210> 14 <211> 805 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность меченного гистидином белка TIC7473. <400> 14 Met Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe Ile 1 5 10 15 Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp Ile 20 25 30 Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu Glu 35 40 45 Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu Glu 50 55 60 Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu Asn 65 70 75 80 Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn Asn 85 90 95 Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met Leu 100 105 110 His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met Lys 115 120 125 Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln Leu 130 135 140 Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu Ile 145 150 155 160 Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr 165 170 175 Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr Leu 180 185 190 Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu Glu 195 200 205 Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 210 215 220 Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu Ile 225 230 235 240 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu Leu 245 250 255 Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys Val 260 265 270 Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe Leu 275 280 285 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp Tyr 290 295 300 Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe Arg 305 310 315 320 Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn Tyr 325 330 335 Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu Ala 340 345 350 Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg Ile 355 360 365 Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln Val 370 375 380 Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys Leu 385 390 395 400 Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu Thr 405 410 415 Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys Leu 420 425 430 Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser Thr 435 440 445 Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu Gln 450 455 460 Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr Met 465 470 475 480 Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser Phe 485 490 495 Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys Lys 500 505 510 Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys Glu 515 520 525 Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val Glu 530 535 540 Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn Asn 545 550 555 560 Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys Ala 565 570 575 Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp Lys 580 585 590 Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly Lys 595 600 605 Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr Glu 610 615 620 Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn Tyr 625 630 635 640 Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser Gln 645 650 655 Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys Lys 660 665 670 Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp Trp 675 680 685 Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile Asp 690 695 700 Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser Tyr 705 710 715 720 Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys Val 725 730 735 Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser Gln 740 745 750 Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr Thr Thr Ser Asn 755 760 765 Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly Phe 770 775 780 Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu His His His 785 790 795 800 His Ala His His His 805 <210> 15 <211> 2397 <212> ДНК <213> Искусственная <220> <223> Синтетическая последовательность ДНК, сконструированная для экспрессии в растении, кодирующая TIC7472PL с дополнительным остатком аланина, встроенным в положении 2 относительно аминокислотной последовательности бактериального TIC7472 полученной из штамма DSC007648 Paenibacillus popilliae, которая кодирует TIC7472. <400> 15 atggctaagc agaacaacaa cttcagcgtg cgggcgctcc cgtccttcat cgacgtcttc 60 aacggcatct acgacttcgc cacgggcatc caggacatct tcaacatgat ctttgggacg 120 gataccggcg acctcaccct cgaagaagtc cttaagaacc aggaactcct gtacgacatc 180 agcgggaagc tggagggcat ctcaggcgac ctgtcggaga tcatcgccca gggcaacctc 240 aacacggagc tcgccaagga actgcttaag atcgccaacg agcagaacaa cgttctgacc 300 gacgtcaaca acaagctcaa cgcgatcaac tccatgctcc acatctacct gccgaagatc 360 accaacatgc tgagcgacgt catgaagcag aactacgcgc tgtcgctcca gatcgagtat 420 ttgagcaagc agctccagga aatctcggac aagctcgacg tgataaacct gaacgtcctc 480 atcaactcca cgctgaccga gatcacaccc gcctaccagc gcatcaagta cgtcaacgag 540 aagttcgacg agctgacgct ggcgaccgag aagaccctgc gggcgaagca aggcagcgag 600 gacattattg cgaacgacac gcttgagaat ctcacggagc tgactgagct ggcgaagtcc 660 gtgaccaaga acgacatgga ctcgttcgag ttctacctac acacctttca tgacgtcctg 720 atcgggaaca acctcttcgg gcgcagcgcg ctcaagaccg ctgcggagct tatcacgaag 780 gacgagatca agacctccgg ctcggagatc gggaaggtgt acagcttcct gatcgtgttg 840 acgtgcctcc aggccaaggc gttcctcacg ctcactgcct gccggaagct cttgggcctc 900 tcagacatcg actacacgaa catcctcaac cagcacctca acgacgagaa gaacgtcttc 960 cgcgacaaca tccttccgac gctttcgaat aagttcagca acccgaacta cgtgaagacc 1020 atcggcagcg ataactacgc gaaggtgata ctggaggcgg agcccggcta cgccctggtc 1080 ggcttcgaga tcattaacga ccgtatcccg gtcctcaagg cgtacaaggc caagctcaag 1140 cagaactacc aagtggacca ccagtccctc tccgagatcg tgtacctgga catcgacaag 1200 ctgttctgcc cgaagaacag cgagcagaag tactacacca agtcgctgac cttcccggac 1260 gggtacgtca tcacaaagat cactttcgag aagaagctga acaacctgcg ctacgaggcg 1320 acggcgaact tctacgaccc gagcaccggt gacatcgacc tgaacgagaa gcaagtggag 1380 tccacgttcc tccaggcgga ctacatctct atcaacgtga gcgacgacga cggcgtgtac 1440 atgccgctgg gcgtcatctc cgagaccttc ctctctccca tcaactcgtt cgagcttgaa 1500 gtggacgaga aatcgaagat cctgacgctg acctgcaaga gctacctgcg cgagtacctg 1560 ctggagtccg acctcatcaa caaggagacc agcctgatcg cgccgcctaa tgtgttcatc 1620 agcaacatcg tggagaactg gaacatcgag gccgacaatt tggaaccctg ggtcgccaac 1680 aacaagaacg cctacgtgga cagcacgggc ggcatcgagg gctccaaggc cctgtttacc 1740 cagggagacg gcgagttcag tcagttcatc ggcgacaagc tcaagcccaa cacggactac 1800 atcatccagt acaccgtcaa agggaagcct gcgatctacc tcaagaacaa gaacaccgga 1860 tacacgatgt acgaggacac caacggctcc tcggaggagt tccagaccat cgcggtgaac 1920 tacacctccg agacggaccc gtcccagacg cacctcgtgt tcaagtccca gtcaggctac 1980 gaagcgtggg gtgacaactt tatcatcctg gagtgcaagg cgttcgagac gcccgagggc 2040 ccggaactca tcaagttcga cgactggatc tcattcggca ccacgtacat ccgggacgac 2100 gtcctcacca tcgacccgtc tcgcggcggc tacttccgcc agtccctcaa gctcgactcg 2160 tacagcacgt acaacctgtc cttctctttc agcgggctgt gggccaaggt catcatcaag 2220 aactcgcatg gcgtcgtcct cttcgagaag gtgtcccagc agagttccta cgtggacatc 2280 aacgagagct tcacgacgac gtccaacaag gagggattct tcatcgagct gaccggcgac 2340 agtcgcggag gcttcgggag cttccgggac ttctccatga aggagaagtt cgagtag 2397 <210> 16 <211> 798 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность TIC7472PL, кодируемая синтетической последовательностью ДНК, при этом дополнительный остаток аланина встроен в положении 2 по отношению к бактериальной аминокислотной последовательности TIC7472. <400> 16 Met Ala Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe 1 5 10 15 Ile Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp 20 25 30 Ile Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu 35 40 45 Glu Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu 50 55 60 Glu Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu 65 70 75 80 Asn Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn 85 90 95 Asn Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met 100 105 110 Leu His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met 115 120 125 Lys Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln 130 135 140 Leu Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu 145 150 155 160 Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys 165 170 175 Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr 180 185 190 Leu Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu 195 200 205 Glu Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn 210 215 220 Asp Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu 225 230 235 240 Ile Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu 245 250 255 Leu Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys 260 265 270 Val Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe 275 280 285 Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp 290 295 300 Tyr Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe 305 310 315 320 Arg Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn 325 330 335 Tyr Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu 340 345 350 Ala Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg 355 360 365 Ile Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln 370 375 380 Val Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys 385 390 395 400 Leu Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu 405 410 415 Thr Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys 420 425 430 Leu Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser 435 440 445 Thr Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu 450 455 460 Gln Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr 465 470 475 480 Met Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser 485 490 495 Phe Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys 500 505 510 Lys Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys 515 520 525 Glu Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val 530 535 540 Glu Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn 545 550 555 560 Asn Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys 565 570 575 Ala Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp 580 585 590 Lys Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly 595 600 605 Lys Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr 610 615 620 Glu Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn 625 630 635 640 Tyr Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser 645 650 655 Gln Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys 660 665 670 Lys Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp 675 680 685 Trp Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile 690 695 700 Asp Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser 705 710 715 720 Tyr Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys 725 730 735 Val Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser 740 745 750 Gln Gln Ser Ser Tyr Val Asp Ile Asn Glu Ser Phe Thr Thr Thr Ser 755 760 765 Asn Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly 770 775 780 Phe Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795 <210> 17 <211> 2397 <212> ДНК <213> Искусственная <220> <223> Синтетическая последовательность ДНК, сконструированная для экспрессии в растении, кодирующая TIC7473PL с дополнительным остатком аланина, встроенным в положении 2 относительно аминокислотной последовательности бактериального TIC7473, полученной из штамма DSC008493 Paenibacillus popilliae, которая кодируюет TIC7473. <400> 17 atggctaagc agaacaacaa cttcagtgtc cgcgccctgc cctccttcat tgacgtcttc 60 aacggcatct acgacttcgc taccggcatc caggacatct tcaacatgat ctttggaacg 120 gataccggcg acctgacgct ggaggaggtg ctcaagaacc aggagctgct ctacgacatc 180 tccgggaagc tggagggcat ctccggcgac ctgtcggaga tcatcgccca gggcaacctc 240 aacacggagt tagccaaaga gctgctcaag atcgccaacg agcagaacaa cgtcctgacc 300 gacgtgaaca acaagctcaa cgccatcaac tccatgctcc acatctacct cccgaagatc 360 accaacatgc tctccgacgt catgaagcag aactacgccc tcagcctcca gatcgagtac 420 ctctccaagc agctacagga gatttccgac aagctggacg tcatcaacct gaacgtcctc 480 atcaattcga cgctcaccga gatcactccg gcgtaccagc gcatcaagta cgtgaacgag 540 aagttcgacg agctgacgct ggcgactgag aagaccctcc gcgccaaaca gggcagcgag 600 gacatcatcg ctaacgacac gctggagaac ctgacggaac tcacggagct ggccaagtcc 660 gtgaccaaga acgacatgga cagcttcgag ttctacctgc atacgttcca cgacgtgctc 720 atcggcaaca acctgttcgg ccgctccgcc ctcaagacgg ccgccgagct gattacaaag 780 gacgagatca agacgagcgg ctcggagatc ggcaaggtgt acagtttcct gatcgtcctg 840 acctgtctcc aggctaaggc gttcctgacg ctaaccgcct gccggaagct cctgggcctc 900 agcgacatcg actacaccaa catcctgaac cagcacctga acgacgagaa gaacgtcttc 960 cgcgacaaca tcctgcccac actgtcgaac aagttctcaa acccgaacta cgtgaagacc 1020 atcgggagcg acaactacgc caaggtgatc ctggaggccg agccgggcta cgcgctggtg 1080 ggcttcgaga tcatcaacga ccgcatcccg gtcctcaagg cgtacaaggc gaagctcaag 1140 cagaactacc aagtggacca ccagagccta tccgagatcg tgtacctgga catcgacaaa 1200 ctgttctgcc cgaagaactc cgagcagaag tactacacca agtcgctcac cttcccggac 1260 ggctacgtca tcaccaagat cacgttcgag aagaagctca acaacctgcg ttacgaggcg 1320 accgccaact tctacgaccc gtccaccggc gacatcgacc ttaacgagaa gcaagtcgag 1380 agcaccttcc tccaggccga ctacatctcc atcaacgtct cggacgacga cggcgtgtac 1440 atgccgctgg gcgtcatctc cgagaccttc ctgagcccga tcaacagctt cgagctggag 1500 gtggacgaga agtccaagat cctgacccta acgtgcaaga gctacctcag ggagtacctc 1560 ctggagtccg acctcatcaa caaggagacg agcctgatcg cgcctccaaa cgtcttcatc 1620 agcaacattg tggagaactg gaacatcgag gcggacaacc tagaaccctg ggtggcgaac 1680 aacaagaacg cctacgtgga cagcaccggc ggcatcgagg gcagcaaagc actgttcact 1740 cagggtgacg gcgagttctc gcagttcatc ggcgacaagc tcaagccaaa caccgactac 1800 atcatccagt acacggtcaa gggcaagcct gctatctacc tcaagaacaa gaacaccggc 1860 tacacgatgt acgaggacac gaacgggtcc agcgaggagt tccagaccat cgccgtgaac 1920 tacaccagcg agaccgaccc gtcccagacc cacctcgtgt tcaagtcgca gagcgggtac 1980 gaggcttggg gagataactt cattatcctg gagtgcaagg cgttcgagac gccggaaggc 2040 ccggagctca tcaagttcga cgactggatc tcgttcggga ccacctacat ccgcgacgac 2100 gtgctcacca tcgacccgag ccgtggcggc tacttccgcc agtccttgaa actcgactcg 2160 tactcgacgt acaacctctc gttcagcttc tcgggcctct gggctaaggt catcatcaag 2220 aactcccacg gcgtcgtcct gttcgagaag gtgtcgcagc agagttcgta cgtggacatc 2280 tcggagtcct tcaccaccac cagcaacaag gagggcttct ttatcgagct cacgggcgac 2340 tcgcgcggcg gcttcggctc gttccgggac tttagtatga aggagaagtt cgagtag 2397 <210> 18 <211> 798 <212> ПРТ <213> Искусственная <220> <223> Аминокислотная последовательность TIC7473PL , кодируемая синтетической последовательностью ДНК, при этом дополнительный остаток аланина встроен в положении 2 по отношению к бактериальной аминокислотной последовательности TIC7473. <400> 18 Met Ala Lys Gln Asn Asn Asn Phe Ser Val Arg Ala Leu Pro Ser Phe 1 5 10 15 Ile Asp Val Phe Asn Gly Ile Tyr Asp Phe Ala Thr Gly Ile Gln Asp 20 25 30 Ile Phe Asn Met Ile Phe Gly Thr Asp Thr Gly Asp Leu Thr Leu Glu 35 40 45 Glu Val Leu Lys Asn Gln Glu Leu Leu Tyr Asp Ile Ser Gly Lys Leu 50 55 60 Glu Gly Ile Ser Gly Asp Leu Ser Glu Ile Ile Ala Gln Gly Asn Leu 65 70 75 80 Asn Thr Glu Leu Ala Lys Glu Leu Leu Lys Ile Ala Asn Glu Gln Asn 85 90 95 Asn Val Leu Thr Asp Val Asn Asn Lys Leu Asn Ala Ile Asn Ser Met 100 105 110 Leu His Ile Tyr Leu Pro Lys Ile Thr Asn Met Leu Ser Asp Val Met 115 120 125 Lys Gln Asn Tyr Ala Leu Ser Leu Gln Ile Glu Tyr Leu Ser Lys Gln 130 135 140 Leu Gln Glu Ile Ser Asp Lys Leu Asp Val Ile Asn Leu Asn Val Leu 145 150 155 160 Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys 165 170 175 Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr Leu Ala Thr Glu Lys Thr 180 185 190 Leu Arg Ala Lys Gln Gly Ser Glu Asp Ile Ile Ala Asn Asp Thr Leu 195 200 205 Glu Asn Leu Thr Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn 210 215 220 Asp Met Asp Ser Phe Glu Phe Tyr Leu His Thr Phe His Asp Val Leu 225 230 235 240 Ile Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ala Glu 245 250 255 Leu Ile Thr Lys Asp Glu Ile Lys Thr Ser Gly Ser Glu Ile Gly Lys 260 265 270 Val Tyr Ser Phe Leu Ile Val Leu Thr Cys Leu Gln Ala Lys Ala Phe 275 280 285 Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Ser Asp Ile Asp 290 295 300 Tyr Thr Asn Ile Leu Asn Gln His Leu Asn Asp Glu Lys Asn Val Phe 305 310 315 320 Arg Asp Asn Ile Leu Pro Thr Leu Ser Asn Lys Phe Ser Asn Pro Asn 325 330 335 Tyr Val Lys Thr Ile Gly Ser Asp Asn Tyr Ala Lys Val Ile Leu Glu 340 345 350 Ala Glu Pro Gly Tyr Ala Leu Val Gly Phe Glu Ile Ile Asn Asp Arg 355 360 365 Ile Pro Val Leu Lys Ala Tyr Lys Ala Lys Leu Lys Gln Asn Tyr Gln 370 375 380 Val Asp His Gln Ser Leu Ser Glu Ile Val Tyr Leu Asp Ile Asp Lys 385 390 395 400 Leu Phe Cys Pro Lys Asn Ser Glu Gln Lys Tyr Tyr Thr Lys Ser Leu 405 410 415 Thr Phe Pro Asp Gly Tyr Val Ile Thr Lys Ile Thr Phe Glu Lys Lys 420 425 430 Leu Asn Asn Leu Arg Tyr Glu Ala Thr Ala Asn Phe Tyr Asp Pro Ser 435 440 445 Thr Gly Asp Ile Asp Leu Asn Glu Lys Gln Val Glu Ser Thr Phe Leu 450 455 460 Gln Ala Asp Tyr Ile Ser Ile Asn Val Ser Asp Asp Asp Gly Val Tyr 465 470 475 480 Met Pro Leu Gly Val Ile Ser Glu Thr Phe Leu Ser Pro Ile Asn Ser 485 490 495 Phe Glu Leu Glu Val Asp Glu Lys Ser Lys Ile Leu Thr Leu Thr Cys 500 505 510 Lys Ser Tyr Leu Arg Glu Tyr Leu Leu Glu Ser Asp Leu Ile Asn Lys 515 520 525 Glu Thr Ser Leu Ile Ala Pro Pro Asn Val Phe Ile Ser Asn Ile Val 530 535 540 Glu Asn Trp Asn Ile Glu Ala Asp Asn Leu Glu Pro Trp Val Ala Asn 545 550 555 560 Asn Lys Asn Ala Tyr Val Asp Ser Thr Gly Gly Ile Glu Gly Ser Lys 565 570 575 Ala Leu Phe Thr Gln Gly Asp Gly Glu Phe Ser Gln Phe Ile Gly Asp 580 585 590 Lys Leu Lys Pro Asn Thr Asp Tyr Ile Ile Gln Tyr Thr Val Lys Gly 595 600 605 Lys Pro Ala Ile Tyr Leu Lys Asn Lys Asn Thr Gly Tyr Thr Met Tyr 610 615 620 Glu Asp Thr Asn Gly Ser Ser Glu Glu Phe Gln Thr Ile Ala Val Asn 625 630 635 640 Tyr Thr Ser Glu Thr Asp Pro Ser Gln Thr His Leu Val Phe Lys Ser 645 650 655 Gln Ser Gly Tyr Glu Ala Trp Gly Asp Asn Phe Ile Ile Leu Glu Cys 660 665 670 Lys Ala Phe Glu Thr Pro Glu Gly Pro Glu Leu Ile Lys Phe Asp Asp 675 680 685 Trp Ile Ser Phe Gly Thr Thr Tyr Ile Arg Asp Asp Val Leu Thr Ile 690 695 700 Asp Pro Ser Arg Gly Gly Tyr Phe Arg Gln Ser Leu Lys Leu Asp Ser 705 710 715 720 Tyr Ser Thr Tyr Asn Leu Ser Phe Ser Phe Ser Gly Leu Trp Ala Lys 725 730 735 Val Ile Ile Lys Asn Ser His Gly Val Val Leu Phe Glu Lys Val Ser 740 745 750 Gln Gln Ser Ser Tyr Val Asp Ile Ser Glu Ser Phe Thr Thr Thr Ser 755 760 765 Asn Lys Glu Gly Phe Phe Ile Glu Leu Thr Gly Asp Ser Arg Gly Gly 770 775 780 Phe Gly Ser Phe Arg Asp Phe Ser Met Lys Glu Lys Phe Glu 785 790 795