ÏÅÐÅ×ÅÍÜ ÏÎÑËÅÄÎÂÀÒÅËÜÍÎÑÒÅÉ <110> BHARAT BIOTECH INTERNATIONAL LIMITED <120> ÂÀÊÖÈÍÍÛÅ ÊÎÌÏÎÇÈÖÈÈ ÄËß ÏÐÎÔÈËÀÊÒÈÊÈ ÀÁÐÎÂÈÐÓÑÍÛÕ ÈÍÔÅÊÖÈÉ <130> P 15-309-IN <140> 3652/CHE/2015 <141> 2015-07-16 <160> 8 <170> PatentIn version 3.5 <210> 1 <211> 2121 <212> ÄÍÊ <213> prME, Çèêà Àçèàòñêèé ãåíîòèï <400> 1 ctcgaggaat tcggatccaa ctcctaaaaa accgccacca tggcagatac cagcgtcggc 60 atcgtcggac tcttgttgat taccacggca atggcagcag aagtgacccg caggggcagc 120 gcctactaca tgtacctcga caggaacgat gcgggagagg ctatcagctt ccctaccact 180 ttgggcatga acaagtgtta catccagatt atggacctgg gtcacatgtg cgatgctacc 240 atgtcttacg aatgtcctat gctggacgag ggcgtggaac ccgacgatgt cgattgctgg 300 tgtaacacaa cgagtacttg ggtggtgtac ggtacatgtc accataagaa aggtgaagct 360 aggcgttcga ggagagctgt gacgctcccc agtcactcga ccaggaagtt gcagactaga 420 agtcaaacat ggctggagtc gcgcgaatac acaaaacatc tgatcagggt cgaaaactgg 480 attttcagaa accctggatt cgctctcgct gccgcagcga tcgcttggct gctcggttcc 540 agcacctccc aaaaggttat ttacctggtc atgatcttgc tgattgctcc cgcctactcc 600 atccgctgca ttggcgttag caaccgtgac ttcgtggagg gaatgagcgg tggcacttgg 660 gtggatgttg tgttggaaca cggaggttgt gtcacggtta tggctcagga caagccaacc 720 gttgatatcg agctggtcac cactacagtt tctaacatgg ctgaggtcag gtcatactgc 780 tacgaagcct ccatcagcga catggcatct gattcaagat gtccgaccca aggtgaagct 840 tacctcgaca agcagtcaga tactcaatac gtctgcaaac gcacattggt tgaccgtggc 900 tggggaaacg gttgtggcct cttcggaaag ggtagtttgg tcacgtgcgc caaattcgca 960 tgtagtaaga aaatgaccgg caagtcgatc cagccagaga acctggaata ccgcattatg 1020 ctctctgtgc acggaagtca acattcgggt atgatcgtca acgacacggg ccacgagacc 1080 gatgaaaacc gcgccaaggt ggagatcacg cctaactctc cccgtgcaga agctaccctc 1140 ggcggattcg gatcactggg tctcgactgc gagccccgta ctggcttgga cttctcagat 1200 ttgtactacc tgacaatgaa caacaagcac tggctcgtcc ataaagaatg gttccacgac 1260 atcccactgc cttggcacgc tggagctgat actggcaccc ctcactggaa caacaaggag 1320 gccctggtgg agttcaagga cgcacatgcg aaacgccaga cagtcgttgt gctcggctcc 1380 caagaaggag ctgtgcacac tgctctggcc ggtgctctgg aggccgaaat ggacggcgca 1440 aagggacgtc tgtcttcagg ccatttgaaa tgcaggctga agatggacaa attgagactg 1500 aagggagtga gttactcgtt gtgtacggct gccttcactt tcacaaaaat ccctgctgag 1560 actctgcacg gcacggtgac cgtcgaagtt cagtacgccg gtactgacgg accatgcaag 1620 gtgccggctc agatggctgt cgatatgcaa actttgacac cagtcggcag gctgatcaca 1680 gctaacccgg ttattacgga gtctaccgaa aactcaaaga tgatgctgga gctggaccct 1740 cctttcggag attcctacat cgtgattggc gtcggagaaa agaaaatcac ccaccattgg 1800 cacagatccg gtagcactat tggcaaggcc ttcgaggcaa cagttcgcgg tgcgaaacgt 1860 atggctgtgc tgggagacac tgcctgggat ttcggttccg tgggtggtgc tctgaactcc 1920 ctgggcaagg gcatccacca gattttcgga gcagcgttca aaagcctgtt cggaggtatg 1980 tcctggttca gccaaatcct cattggtact ctcttgatgt ggctgggcct caacacaaag 2040 aacggatcta tctcactgat gtgcttggct ttgggaggtg ttttgatctt cttgtctact 2100 gctgtgagcg ccgatgtggg a 2121 <210> 2 <211> 2079 <212> ÄÍÊ <213> prME, Çèêà MR766 <400> 2 atggcagaca ccagcatcgg aatcattggc ctcctgctga ctacagccat ggcagcagag 60 atcactagac gcgggagtgc atactacatg tacttggata ggagcgatgc cgggaaggcc 120 atttcgtttg ctaccacatt gggagtgaac aagtgccacg tacagatcat ggacctcggg 180 cacatgtgtg acgccaccat gagttatgag tgccctatgc tggatgaggg agtggaacca 240 gatgatgtcg attgctggtg caacacgaca tcaacttggg ttgtgtacgg aacctgtcat 300 cacaaaaaag gtgaggcacg gcgatctaga agagccgtga cgctcccttc tcactctaca 360 aggaagttgc aaacgcggtc gcagacctgg ttagaatcaa gagaatacac gaagcacttg 420 atcaaggttg aaaactggat attcaggaac cccgggtttg cgctagtggc cgttgccatt 480 gcctggcttt tgggaagctc gacgagccaa aaagtcatat acttggtcat gatactgctg 540 attgccccgg catacagtat caggtgcatt ggagtcagca atagagactt cgtggagggc 600 atgtcaggtg ggacctgggt tgatgttgtc ttggaacatg gaggctgcgt taccgtgatg 660 gcacaggaca agccaacagt tgacatagag ttggtcacga cgacggttag taacatggcc 720 gaggtaagat cctattgcta cgaggcatcg atatcggaca tggcttcgga cagtcgttgc 780 ccaacacaag gtgaagccta ccttgacaag caatcagaca ctcaatatgt ctgcaaaaga 840 acattagtgg acagaggttg gggaaacggt tgtggacttt ttggcaaagg gagcttggtg 900 acatgtgcca agtttacgtg ttctaagaag atgaccggga agagcattca accggaaaat 960 ctggagtatc ggataatgct atcagtgcat ggctcccagc atagcgggat gattgtcaat 1020 gatacaggat atgaaactga cgaaaataga gcgaaagtcg aggttacgcc taattcacca 1080 agagcggaag caaccttggg aggctttgga agcttaggac ttgactgtga accaaggaca 1140 ggccttgact tttcagatct gtattacctg accatgaaca ataagcattg gttggtgcac 1200 aaagagtggt ttcatgacat cccattgcct tggcatgctg gggcagacac cggaactcca 1260 cactggaaca acaaagaggc attggtagaa ttcaaggatg cccacgccaa gaggcaaacc 1320 gtcgtcgttc tggggagcca ggaaggagcc gttcacacgg ctctcgctgg agctctagag 1380 gctgagatgg atggtgcaaa gggaaagctg ttctctggcc atttgaaatg ccgcctaaaa 1440 atggacaagc ttagattgaa gggcgtgtca tattccttgt gcactgcggc attcacattc 1500 accaaggtcc cagctgaaac actgcatgga acagtcacag tggaggtgca gtatgcaggg 1560 acagatggac cctgcaagat cccagtccag atggcggtgg acatgcagac cctgacccca 1620 gttggaaggc tgataaccgc caaccccgtg attactgaaa gcactgagaa ctcaaagatg 1680 atgttggagc ttgacccacc atttggggat tcttacattg tcataggagt tggggacaag 1740 aaaatcaccc accactggca taggagtggt agcaccatcg gaaaggcatt tgaggccact 1800 gtgagaggcg ccaagagaat ggcagtcctg ggggatacag cctgggactt cggatcagtc 1860 gggggtgtgt tcaactcact gggtaagggc attcaccaga tttttggagc agccttcaaa 1920 tcactgtttg gaggaatgtc ctggttctca cagatcctca taggcacgct gctagtgtgg 1980 ttaggtttga acacaaagaa tggatctatc tccctcacat gcttggccct ggggggagtg 2040 atgatcttcc tctccacggc tgtttctgct gacgtgggg 2079 <210> 3 <211> 694 <212> PRT <213> prME, Çèêà Àçèàòñêèé ãåíîòèï <400> 3 Met Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Ile Thr Thr 1 5 10 15 Ala Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr 20 25 30 Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu 35 40 45 Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys 50 55 60 Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu 65 70 75 80 Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val 85 90 95 Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg 100 105 110 Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser 115 120 125 Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val 130 135 140 Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala 145 150 155 160 Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu 165 170 175 Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly 180 185 190 Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val 195 200 205 Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp 210 215 220 Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met 225 230 235 240 Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala 245 250 255 Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln 260 265 270 Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp 275 280 285 Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala 290 295 300 Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu 305 310 315 320 Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser 325 330 335 Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala 340 345 350 Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly 355 360 365 Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp 370 375 380 Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val 385 390 395 400 His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala 405 410 415 Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe 420 425 430 Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln 435 440 445 Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met 450 455 460 Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg Leu 465 470 475 480 Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr 485 490 495 Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr 500 505 510 Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val 515 520 525 Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg 530 535 540 Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys 545 550 555 560 Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile 565 570 575 Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser 580 585 590 Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met 595 600 605 Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Ala 610 615 620 Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe 625 630 635 640 Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly 645 650 655 Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser 660 665 670 Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile Phe Leu Ser Thr Ala 675 680 685 Val Ser Ala Asp Val Gly 690 <210> 4 <211> 693 <212> PRT <213> prME, Çèêà øòàìì MR766 <400> 4 Met Ala Asp Thr Ser Ile Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala 1 5 10 15 Met Ala Ala Glu Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu 20 25 30 Asp Arg Ser Asp Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr Leu Gly 35 40 45 Val Asn Lys Cys His Val Gln Ile Met Asp Leu Gly His Met Cys Asp 50 55 60 Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro 65 70 75 80 Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr 85 90 95 Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala 100 105 110 Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln 115 120 125 Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Lys Val Glu 130 135 140 Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Val Ala Val Ala Ile 145 150 155 160 Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val 165 170 175 Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val 180 185 190 Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp 195 200 205 Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys 210 215 220 Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala 225 230 235 240 Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser 245 250 255 Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser 260 265 270 Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly 275 280 285 Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys 290 295 300 Phe Thr Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn 305 310 315 320 Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly 325 330 335 Met Ile Val Asn Asp Thr Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys 340 345 350 Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly 355 360 365 Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe 370 375 380 Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His 385 390 395 400 Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp 405 410 415 Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys 420 425 430 Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu 435 440 445 Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp 450 455 460 Gly Ala Lys Gly Lys Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys 465 470 475 480 Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala 485 490 495 Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val 500 505 510 Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Ile Pro 515 520 525 Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu 530 535 540 Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met 545 550 555 560 Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly 565 570 575 Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr 580 585 590 Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala 595 600 605 Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe 610 615 620 Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys 625 630 635 640 Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr 645 650 655 Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu 660 665 670 Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val 675 680 685 Ser Ala Asp Val Gly 690 <210> 5 <211> 10269 <212> ÄÍÊ <213> Çèêà øòàìì MR766 <400> 5 atgaaaaacc caaagaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga 60 gtagcccgtg taaacccctt gggaggtttg aagaggttgc cagccggact tctgctgggt 120 catggaccca tcagaatggt tttggcgata ctagcctttt tgagatttac agcaatcaag 180 ccatcactgg gccttatcaa cagatggggt tccgtgggga aaaaagaggc tatggaaata 240 ataaagaagt tcaagaaaga tcttgctgcc atgttgagaa taatcaatgc taggaaagag 300 aggaagagac gtggcgcaga caccagcatc ggaatcattg gcctcctgct gactacagcc 360 atggcagcag agatcactag acgcgggagt gcatactaca tgtacttgga taggagcgat 420 gccgggaagg ccatttcgtt tgctaccaca ttgggagtga acaagtgcca cgtacagatc 480 atggacctcg ggcacatgtg tgacgccacc atgagttatg agtgccctat gctggatgag 540 ggagtggaac cagatgatgt cgattgctgg tgcaacacga catcaacttg ggttgtgtac 600 ggaacctgtc atcacaaaaa aggtgaggca cggcgatcta gaagagccgt gacgctccct 660 tctcactcta caaggaagtt gcaaacgcgg tcgcagacct ggttagaatc aagagaatac 720 acgaagcact tgatcaaggt tgaaaactgg atattcagga accccgggtt tgcgctagtg 780 gccgttgcca ttgcctggct tttgggaagc tcgacgagcc aaaaagtcat atacttggtc 840 atgatactgc tgattgcccc ggcatacagt atcaggtgca ttggagtcag caatagagac 900 ttcgtggagg gcatgtcagg tgggacctgg gttgatgttg tcttggaaca tggaggctgc 960 gttaccgtga tggcacagga caagccaaca gttgacatag agttggtcac gacgacggtt 1020 agtaacatgg ccgaggtaag atcctattgc tacgaggcat cgatatcgga catggcttcg 1080 gacagtcgtt gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat 1140 gtctgcaaaa gaacattagt ggacagaggt tggggaaacg gttgtggact ttttggcaaa 1200 gggagcttgg tgacatgtgc caagtttacg tgttctaaga agatgaccgg gaagagcatt 1260 caaccggaaa atctggagta tcggataatg ctatcagtgc atggctccca gcatagcggg 1320 atgattgtca atgatacagg atatgaaact gacgaaaata gagcgaaagt cgaggttacg 1380 cctaattcac caagagcgga agcaaccttg ggaggctttg gaagcttagg acttgactgt 1440 gaaccaagga caggccttga cttttcagat ctgtattacc tgaccatgaa caataagcat 1500 tggttggtgc acaaagagtg gtttcatgac atcccattgc cttggcatgc tggggcagac 1560 accggaactc cacactggaa caacaaagag gcattggtag aattcaagga tgcccacgcc 1620 aagaggcaaa ccgtcgtcgt tctggggagc caggaaggag ccgttcacac ggctctcgct 1680 ggagctctag aggctgagat ggatggtgca aagggaaagc tgttctctgg ccatttgaaa 1740 tgccgcctaa aaatggacaa gcttagattg aagggcgtgt catattcctt gtgcactgcg 1800 gcattcacat tcaccaaggt cccagctgaa acactgcatg gaacagtcac agtggaggtg 1860 cagtatgcag ggacagatgg accctgcaag atcccagtcc agatggcggt ggacatgcag 1920 accctgaccc cagttggaag gctgataacc gccaaccccg tgattactga aagcactgag 1980 aactcaaaga tgatgttgga gcttgaccca ccatttgggg attcttacat tgtcatagga 2040 gttggggaca agaaaatcac ccaccactgg cataggagtg gtagcaccat cggaaaggca 2100 tttgaggcca ctgtgagagg cgccaagaga atggcagtcc tgggggatac agcctgggac 2160 ttcggatcag tcgggggtgt gttcaactca ctgggtaagg gcattcacca gatttttgga 2220 gcagccttca aatcactgtt tggaggaatg tcctggttct cacagatcct cataggcacg 2280 ctgctagtgt ggttaggttt gaacacaaag aatggatcta tctccctcac atgcttggcc 2340 ctggggggag tgatgatctt cctctccacg gctgtttctg ctgacgtggg gtgctcagtg 2400 gacttctcaa aaaaggaaac gagatgtggc acgggggtat tcatctataa tgatgttgaa 2460 gcctggaggg accggtacaa gtaccatcct gactcccccc gcagattggc agcagcagtc 2520 aagcaggcct gggaagaggg gatctgtggg atctcatccg tttcaagaat ggaaaacatc 2580 atgtggaaat cagtagaagg ggagctcaat gctatcctag aggagaatgg agttcaactg 2640 acagttgttg tgggatctgt aaaaaacccc atgtggagag gtccacaaag attgccagtg 2700 cctgtgaatg agctgcccca tggctggaaa gcctggggga aatcgtattt tgttagggcg 2760 gcaaagacca acaacagttt tgttgtcgac ggtgacacac tgaaggaatg tccgcttgag 2820 cacagagcat ggaatagttt tcttgtggag gatcacgggt ttggagtctt ccacaccagt 2880 gtctggctta aggtcagaga agattactca ttagaatgtg acccagccgt cataggaaca 2940 gctgttaagg gaagggaggc cgcgcacagt gatctgggct attggattga aagtgaaaag 3000 aatgacacat ggaggctgaa gagggcccac ctgattgaga tgaaaacatg tgaatggcca 3060 aagtctcaca cattgtggac agatggagta gaagaaagtg atcttatcat acccaagtct 3120 ttagctggtc cactcagcca ccacaacacc agagagggtt acagaaccca agtgaaaggg 3180 ccatggcaca gtgaagagct tgaaatccgg tttgaggaat gtccaggcac caaggtttac 3240 gtggaggaga catgcggaac tagaggacca tctctgagat caactactgc aagtggaagg 3300 gtcattgagg aatggtgctg tagggaatgc acaatgcccc cactatcgtt tcgagcaaaa 3360 gacggctgct ggtatggaat ggagataagg cccaggaaag aaccagagag caacttagtg 3420 aggtcaatgg tgacagcggg gtcaaccgat catatggacc acttctctct tggagtgctt 3480 gtgattctac tcatggtgca ggaggggttg aagaagagaa tgaccacaaa gatcatcatg 3540 agcacatcaa tggcagtgct ggtagtcatg atcttgggag gattttcaat gagtgacctg 3600 gccaagcttg tgatcctgat gggtgctact ttcgcagaaa tgaacactgg aggagatgta 3660 gctcacttgg cattggtagc ggcatttaaa gtcagaccag ccttgctggt ctccttcatt 3720 ttcagagcca attggacacc ccgtgagagc atgctgctag ccctggcttc gtgtcttctg 3780 caaactgcga tctctgctct tgaaggtgac ttgatggtcc tcattaatgg atttgctttg 3840 gcctggttgg caattcgagc aatggccgtg ccacgcactg acaacatcgc tctaccaatc 3900 ttggctgctc taacaccact agctcgaggc acactgctcg tggcatggag agcgggcctg 3960 gctacttgtg gagggatcat gctcctctcc ctgaaaggga aaggtagtgt gaagaagaac 4020 ctgccatttg tcatggccct gggattgaca gctgtgaggg tagtagaccc tattaatgtg 4080 gtaggactac tgttactcac aaggagtggg aagcggagct ggccccctag tgaagttctc 4140 acagccgttg gcctgatatg tgcactggcc ggagggtttg ccaaggcaga cattgagatg 4200 gctggaccca tggctgcagt aggcttgcta attgtcagct atgtggtctc gggaaagagt 4260 gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaggacgc ggaagtcact 4320 ggaaacagtc ctcggcttga cgtggcactg gatgagagtg gtgatttctc cttggtagag 4380 gaagatggtc cacccatgag agagatcata ctcaaggtgg tcctgatggc catctgtggc 4440 atgaacccaa tagctatacc ttttgctgca ggagcgtggt atgtgtatgt gaagactggg 4500 aaaaggagtg gcgccctctg ggacgtgcct gctcccaaag aagtgaagaa aggagagacc 4560 acagatggag tgtacagagt gatgactcgc agactgctag gttcaacaca ggttggagtg 4620 ggagtcatgc aagagggagt cttccacacc atgtggcacg ttacaaaagg agccgcactg 4680 aggagcggtg agggaagact tgatccatac tggggggatg tcaagcagga cttggtgtca 4740 tactgtgggc cttggaagtt ggatgcagct tgggatggac tcagcgaggt acagcttttg 4800 gccgtacctc ccggagagag ggccagaaac attcagaccc tgcctggaat attcaagaca 4860 aaggacgggg acatcggagc agttgctctg gactaccctg cagggacctc aggatctccg 4920 atcctagaca aatgtggaag agtgatagga ctctatggca atggggttgt gatcaagaat 4980 ggaagctatg ttagtgctat aacccaggga aagagggagg aggagactcc ggttgaatgt 5040 ttcgaaccct cgatgctgaa gaagaagcag ctaactgtct tggatctgca tccaggagcc 5100 ggaaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaaa gagactccgg 5160 acagtgatct tggcaccaac tagggttgtc gctgctgaga tggaggaggc cttgagagga 5220 cttccggtgc gttacatgac aacagcagtc aacgtcaccc attctgggac agaaatcgtt 5280 gatttgatgt gccatgccac tttcacttca cgcttactac aacccatcag agtccctaat 5340 tacaatctct acatcatgga tgaagcccac ttcacagacc cctcaagtat agctgcaaga 5400 ggatacatat caacaagggt tgaaatgggc gaggcggctg ccatttttat gactgccaca 5460 ccaccaggaa cccgtgatgc gtttcctgac tctaactcac caatcatgga cacagaagtg 5520 gaagtcccag agagagcctg gagctcaggc tttgattggg tgacagacca ttctgggaaa 5580 acagtttggt tcgttccaag cgtgagaaac ggaaatgaaa tcgcagcctg tctgacaaag 5640 gctggaaagc gggtcataca gctcagcagg aagacttttg agacagaatt tcagaaaaca 5700 aaaaatcaag agtgggactt tgtcataaca actgacatct cagagatggg cgccaacttc 5760 aaggctgacc gggtcataga ctctaggaga tgcctaaaac cagtcatact tgatggtgag 5820 agagtcatct tggctgggcc catgcctgtc acgcatgcta gtgctgctca gaggagagga 5880 cgtataggca ggaaccctaa caaacctgga gatgagtaca tgtatggagg tgggtgtgca 5940 gagactgatg aaggccatgc acactggctt gaagcaagaa tgcttcttga caacatctac 6000 ctccaggatg gcctcatagc ctcgctctat cggcctgagg ccgataaggt agccgccatt 6060 gagggagagt ttaagctgag gacagagcaa aggaagacct tcgtggaact catgaagaga 6120 ggagaccttc ccgtctggct agcctatcag gttgcatctg ccggaataac ttacacagac 6180 agaagatggt gctttgatgg cacaaccaac aacaccataa tggaagacag cgtaccagca 6240 gaggtgtgga caaagtatgg agagaagaga gtgctcaaac cgagatggat ggatgctagg 6300 gtctgttcag accatgcggc cctgaagtcg ttcaaagaat tcgccgctgg aaaaagagga 6360 gcggctttgg gagtaatgga ggccctggga acactgccag gacacatgac agagaggttt 6420 caggaagcca ttgacaacct cgccgtgctc atgcgagcag agactggaag caggccttat 6480 aaggcagcgg cagcccaact gccggagacc ctagagacca ttatgctctt aggtttgctg 6540 ggaacagttt cactggggat cttcttcgtc ttgatgcgga ataagggcat cgggaagatg 6600 ggctttggaa tggtaaccct tggggccagt gcatggctca tgtggctttc ggaaattgaa 6660 ccagccagaa ttgcatgtgt cctcattgtt gtgtttttat tactggtggt gctcataccc 6720 gagccagaga agcaaagatc tccccaagat aaccagatgg caattatcat catggtggca 6780 gtgggccttc taggtttgat aactgcaaac gaacttggat ggctggaaag aacaaaaaat 6840 gacatagctc atctaatggg aaggagagaa gaaggagcaa ccatgggatt ctcaatggac 6900 attgatctgc ggccagcctc cgcctgggct atctatgccg cattgacaac tctcatcacc 6960 ccagctgtcc aacatgcggt aaccacttca tacaacaact actccttaat ggcgatggcc 7020 acacaagctg gagtgctgtt tggcatgggc aaagggatgc cattttatgc atgggacctt 7080 ggagtcccgc tgctaatgat gggttgctat tcacaattaa cacccctgac tctgatagta 7140 gctatcattc tgcttgtggc gcactacatg tacttgatcc caggcctaca agcggcagca 7200 gcgcgtgctg cccagaaaag gacagcagct ggcatcatga agaatcccgt tgtggatgga 7260 atagtggtaa ctgacattga cacaatgaca atagaccccc aggtggagaa gaagatggga 7320 caagtgttac tcatagcagt agccatctcc agtgctgtgc tgctgcggac cgcctgggga 7380 tggggggagg ctggagctct gatcacagca gcgacctcca ccttgtggga aggctctcca 7440 aacaaatact ggaactcctc tacagccacc tcactgtgca acatcttcag aggaagctat 7500 ctggcaggag cttcccttat ctatacagtg acgagaaacg ctggcctggt taagagacgt 7560 ggaggtggga cgggagagac tctgggagag aagtggaaag ctcgtctgaa tcagatgtcg 7620 gccctggagt tctactctta taaaaagtca ggtatcactg aagtgtgtag agaggaggct 7680 cgccgtgccc tcaaggatgg agtggccaca ggaggacatg ccgtatcccg gggaagtgca 7740 aagctcagat ggttggtgga gagaggatat ctgcagccct atgggaaggt tgttgacctc 7800 ggatgtggca gagggggctg gagctattat gccgccacca tccgcaaagt gcaggaggtg 7860 agaggataca caaagggagg tcccggtcat gaagaaccca tgctggtgca aagctatggg 7920 tggaacatag ttcgtctcaa gagtggagtg gacgtcttcc acatggcggc tgagccgtgt 7980 gacactctgc tgtgtgacat aggtgagtca tcatctagtc ctgaagtgga agagacacga 8040 acactcagag tgctctctat ggtgggggac tggcttgaaa aaagaccagg ggccttctgt 8100 ataaaggtgc tgtgcccata caccagcact atgatggaaa ccatggagcg actgcaacgt 8160 aggcatgggg gaggattagt cagagtgcca ttgtctcgca actccacaca tgagatgtac 8220 tgggtctctg gggcaaagag caacatcata aaaagtgtgt ccaccacaag tcagctcctc 8280 ctgggacgca tggatggccc caggaggcca gtgaaatatg aggaggatgt gaacctcggc 8340 tcgggtacac gagctgtggc aagctgtgct gaggctccta acatgaaaat catcggcagg 8400 cgcattgaga gaatccgcaa tgaacatgca gaaacatggt ttcttgatga aaaccaccca 8460 tacaggacat gggcctacca tgggagctac gaagccccca cgcaaggatc agcgtcttcc 8520 ctcgtgaacg gggttgttag actcctgtca aagccttggg acgtggtgac tggagttaca 8580 ggaatagcca tgactgacac cacaccatac ggccaacaaa gagtcttcaa agaaaaagtg 8640 gacaccaggg tgccagatcc ccaagaaggc actcgccagg taatgaacat agtctcttcc 8700 tggctgtgga aggagctggg gaaacgcaag cggccacgcg tctgcaccaa agaagagttt 8760 atcaacaagg tgcgcagcaa tgcagcactg ggagcaatat ttgaagagga aaaagaatgg 8820 aagacggctg tggaagctgt gaatgatcca aggttttggg ccctagtgga tagggagaga 8880 gaacaccacc tgagaggaga gtgtcacagc tgtgtgtaca acatgatggg aaaaagagaa 8940 aagaagcaag gagagttcgg gaaagcaaaa ggtagccgcg ccatctggta catgtggttg 9000 ggagccagat tcttggagtt tgaagccctt ggattcttga acgaggacca ttggatggga 9060 agagaaaact caggaggtgg agtcgaaggg ttaggattgc aaagacttgg atacattcta 9120 gaagaaatga atcgggcacc aggaggaaag atgtacgcag atgacactgc tggctgggac 9180 acccgcatta gtaagtttga tctggagaat gaagctctga ttaccaacca aatggaggaa 9240 gggcacagaa ctctggcgtt ggccgtgatt aaatacacat accaaaacaa agtggtgaag 9300 gttctcagac cagctgaagg aggaaaaaca gttatggaca tcatttcaag acaagaccag 9360 agagggagtg gacaagttgt cacttatgct ctcaacacat tcaccaactt ggtggtgcag 9420 cttatccgga acatggaagc tgaggaagtg ttagagatgc aagacttatg gttgttgagg 9480 aagccagaga aagtgaccag atggttgcag agcaatggat gggatagact caaacgaatg 9540 gcggtcagtg gagatgactg cgttgtgaag ccaatcgatg ataggtttgc acatgccctc 9600 aggttcttga atgacatggg aaaagttagg aaagacacac aggagtggaa accctcgact 9660 ggatggagca attgggaaga agtcccgttc tgctcccacc acttcaacaa gctgtacctc 9720 aaggatggga gatccattgt ggtcccttgc cgccaccaag atgaactgat tggccgagct 9780 cgcgtctcac caggggcagg atggagcatc cgggagactg cctgtcttgc aaaatcatat 9840 gcgcagatgt ggcagctcct ttatttccac agaagagacc ttcgactgat ggctaatgcc 9900 atttgctcgg ctgtgccagt tgactgggta ccaactggga gaaccacctg gtcaatccat 9960 ggaaagggag aatggatgac cactgaggac atgctcatgg tgtggaatag agtgtggatt 10020 gaggagaacg accatatgga ggacaagact cctgtaacaa aatggacaga cattccctat 10080 ctaggaaaaa gggaggactt atggtgtgga tcccttatag ggcacagacc ccgcaccact 10140 tgggctgaaa acatcaaaga cacagtcaac atggtgcgca ggatcatagg tgatgaagaa 10200 aagtacatgg actatctatc cacccaagtc cgctacttgg gtgaggaagg gtccacaccc 10260 ggagtgttg 10269 <210> 6 <211> 3423 <212> PRT <213> Ïîëíûé ORF, Çèêà øòàìì MR766 <400> 6 Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 1 5 10 15 Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 20 25 30 Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 35 40 45 Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 50 55 60 Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 65 70 75 80 Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 85 90 95 Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 100 105 110 Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 115 120 125 Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 130 135 140 Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 145 150 155 160 Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 165 170 175 Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 180 185 190 Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 195 200 205 Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 210 215 220 Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 225 230 235 240 Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 245 250 255 Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 260 265 270 Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 275 280 285 Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 290 295 300 Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 305 310 315 320 Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 325 330 335 Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 340 345 350 Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 355 360 365 Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 370 375 380 Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 385 390 395 400 Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 405 410 415 Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 420 425 430 Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly Tyr 435 440 445 Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro 450 455 460 Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 465 470 475 480 Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 485 490 495 Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 500 505 510 Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 515 520 525 Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 530 535 540 Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 545 550 555 560 Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu Phe Ser 565 570 575 Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 580 585 590 Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro 595 600 605 Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 610 615 620 Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln 625 630 635 640 Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 645 650 655 Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 660 665 670 Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His 675 680 685 His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 690 695 700 Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 705 710 715 720 Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His 725 730 735 Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 740 745 750 Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 755 760 765 Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val 770 775 780 Met Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 785 790 795 800 Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr 805 810 815 Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 820 825 830 Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile 835 840 845 Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser 850 855 860 Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 865 870 875 880 Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 885 890 895 Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 900 905 910 Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 915 920 925 Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp 930 935 940 Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 945 950 955 960 Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 965 970 975 Val Ile Gly Thr Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu 980 985 990 Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg 995 1000 1005 Ala His Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His 1010 1015 1020 Thr Leu Trp Thr Asp Gly Val Glu Glu Ser Asp Leu Ile Ile Pro 1025 1030 1035 Lys Ser Leu Ala Gly Pro Leu Ser His His Asn Thr Arg Glu Gly 1040 1045 1050 Tyr Arg Thr Gln Val Lys Gly Pro Trp His Ser Glu Glu Leu Glu 1055 1060 1065 Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val Tyr Val Glu Glu 1070 1075 1080 Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser 1085 1090 1095 Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro 1100 1105 1110 Pro Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu 1115 1120 1125 Ile Arg Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met 1130 1135 1140 Val Thr Ala Gly Ser Thr Asp His Met Asp His Phe Ser Leu Gly 1145 1150 1155 Val Leu Val Ile Leu Leu Met Val Gln Glu Gly Leu Lys Lys Arg 1160 1165 1170 Met Thr Thr Lys Ile Ile Met Ser Thr Ser Met Ala Val Leu Val 1175 1180 1185 Val Met Ile Leu Gly Gly Phe Ser Met Ser Asp Leu Ala Lys Leu 1190 1195 1200 Val Ile Leu Met Gly Ala Thr Phe Ala Glu Met Asn Thr Gly Gly 1205 1210 1215 Asp Val Ala His Leu Ala Leu Val Ala Ala Phe Lys Val Arg Pro 1220 1225 1230 Ala Leu Leu Val Ser Phe Ile Phe Arg Ala Asn Trp Thr Pro Arg 1235 1240 1245 Glu Ser Met Leu Leu Ala Leu Ala Ser Cys Leu Leu Gln Thr Ala 1250 1255 1260 Ile Ser Ala Leu Glu Gly Asp Leu Met Val Leu Ile Asn Gly Phe 1265 1270 1275 Ala Leu Ala Trp Leu Ala Ile Arg Ala Met Ala Val Pro Arg Thr 1280 1285 1290 Asp Asn Ile Ala Leu Pro Ile Leu Ala Ala Leu Thr Pro Leu Ala 1295 1300 1305 Arg Gly Thr Leu Leu Val Ala Trp Arg Ala Gly Leu Ala Thr Cys 1310 1315 1320 Gly Gly Ile Met Leu Leu Ser Leu Lys Gly Lys Gly Ser Val Lys 1325 1330 1335 Lys Asn Leu Pro Phe Val Met Ala Leu Gly Leu Thr Ala Val Arg 1340 1345 1350 Val Val Asp Pro Ile Asn Val Val Gly Leu Leu Leu Leu Thr Arg 1355 1360 1365 Ser Gly Lys Arg Ser Trp Pro Pro Ser Glu Val Leu Thr Ala Val 1370 1375 1380 Gly Leu Ile Cys Ala Leu Ala Gly Gly Phe Ala Lys Ala Asp Ile 1385 1390 1395 Glu Met Ala Gly Pro Met Ala Ala Val Gly Leu Leu Ile Val Ser 1400 1405 1410 Tyr Val Val Ser Gly Lys Ser Val Asp Met Tyr Ile Glu Arg Ala 1415 1420 1425 Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser 1430 1435 1440 Pro Arg Leu Asp Val Ala Leu Asp Glu Ser Gly Asp Phe Ser Leu 1445 1450 1455 Val Glu Glu Asp Gly Pro Pro Met Arg Glu Ile Ile Leu Lys Val 1460 1465 1470 Val Leu Met Ala Ile Cys Gly Met Asn Pro Ile Ala Ile Pro Phe 1475 1480 1485 Ala Ala Gly Ala Trp Tyr Val Tyr Val Lys Thr Gly Lys Arg Ser 1490 1495 1500 Gly Ala Leu Trp Asp Val Pro Ala Pro Lys Glu Val Lys Lys Gly 1505 1510 1515 Glu Thr Thr Asp Gly Val Tyr Arg Val Met Thr Arg Arg Leu Leu 1520 1525 1530 Gly Ser Thr Gln Val Gly Val Gly Val Met Gln Glu Gly Val Phe 1535 1540 1545 His Thr Met Trp His Val Thr Lys Gly Ala Ala Leu Arg Ser Gly 1550 1555 1560 Glu Gly Arg Leu Asp Pro Tyr Trp Gly Asp Val Lys Gln Asp Leu 1565 1570 1575 Val Ser Tyr Cys Gly Pro Trp Lys Leu Asp Ala Ala Trp Asp Gly 1580 1585 1590 Leu Ser Glu Val Gln Leu Leu Ala Val Pro Pro Gly Glu Arg Ala 1595 1600 1605 Arg Asn Ile Gln Thr Leu Pro Gly Ile Phe Lys Thr Lys Asp Gly 1610 1615 1620 Asp Ile Gly Ala Val Ala Leu Asp Tyr Pro Ala Gly Thr Ser Gly 1625 1630 1635 Ser Pro Ile Leu Asp Lys Cys Gly Arg Val Ile Gly Leu Tyr Gly 1640 1645 1650 Asn Gly Val Val Ile Lys Asn Gly Ser Tyr Val Ser Ala Ile Thr 1655 1660 1665 Gln Gly Lys Arg Glu Glu Glu Thr Pro Val Glu Cys Phe Glu Pro 1670 1675 1680 Ser Met Leu Lys Lys Lys Gln Leu Thr Val Leu Asp Leu His Pro 1685 1690 1695 Gly Ala Gly Lys Thr Arg Arg Val Leu Pro Glu Ile Val Arg Glu 1700 1705 1710 Ala Ile Lys Lys Arg Leu Arg Thr Val Ile Leu Ala Pro Thr Arg 1715 1720 1725 Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu Pro Val 1730 1735 1740 Arg Tyr Met Thr Thr Ala Val Asn Val Thr His Ser Gly Thr Glu 1745 1750 1755 Ile Val Asp Leu Met Cys His Ala Thr Phe Thr Ser Arg Leu Leu 1760 1765 1770 Gln Pro Ile Arg Val Pro Asn Tyr Asn Leu Tyr Ile Met Asp Glu 1775 1780 1785 Ala His Phe Thr Asp Pro Ser Ser Ile Ala Ala Arg Gly Tyr Ile 1790 1795 1800 Ser Thr Arg Val Glu Met Gly Glu Ala Ala Ala Ile Phe Met Thr 1805 1810 1815 Ala Thr Pro Pro Gly Thr Arg Asp Ala Phe Pro Asp Ser Asn Ser 1820 1825 1830 Pro Ile Met Asp Thr Glu Val Glu Val Pro Glu Arg Ala Trp Ser 1835 1840 1845 Ser Gly Phe Asp Trp Val Thr Asp His Ser Gly Lys Thr Val Trp 1850 1855 1860 Phe Val Pro Ser Val Arg Asn Gly Asn Glu Ile Ala Ala Cys Leu 1865 1870 1875 Thr Lys Ala Gly Lys Arg Val Ile Gln Leu Ser Arg Lys Thr Phe 1880 1885 1890 Glu Thr Glu Phe Gln Lys Thr Lys Asn Gln Glu Trp Asp Phe Val 1895 1900 1905 Ile Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe Lys Ala Asp 1910 1915 1920 Arg Val Ile Asp Ser Arg Arg Cys Leu Lys Pro Val Ile Leu Asp 1925 1930 1935 Gly Glu Arg Val Ile Leu Ala Gly Pro Met Pro Val Thr His Ala 1940 1945 1950 Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn Pro Asn Lys 1955 1960 1965 Pro Gly Asp Glu Tyr Met Tyr Gly Gly Gly Cys Ala Glu Thr Asp 1970 1975 1980 Glu Gly His Ala His Trp Leu Glu Ala Arg Met Leu Leu Asp Asn 1985 1990 1995 Ile Tyr Leu Gln Asp Gly Leu Ile Ala Ser Leu Tyr Arg Pro Glu 2000 2005 2010 Ala Asp Lys Val Ala Ala Ile Glu Gly Glu Phe Lys Leu Arg Thr 2015 2020 2025 Glu Gln Arg Lys Thr Phe Val Glu Leu Met Lys Arg Gly Asp Leu 2030 2035 2040 Pro Val Trp Leu Ala Tyr Gln Val Ala Ser Ala Gly Ile Thr Tyr 2045 2050 2055 Thr Asp Arg Arg Trp Cys Phe Asp Gly Thr Thr Asn Asn Thr Ile 2060 2065 2070 Met Glu Asp Ser Val Pro Ala Glu Val Trp Thr Lys Tyr Gly Glu 2075 2080 2085 Lys Arg Val Leu Lys Pro Arg Trp Met Asp Ala Arg Val Cys Ser 2090 2095 2100 Asp His Ala Ala Leu Lys Ser Phe Lys Glu Phe Ala Ala Gly Lys 2105 2110 2115 Arg Gly Ala Ala Leu Gly Val Met Glu Ala Leu Gly Thr Leu Pro 2120 2125 2130 Gly His Met Thr Glu Arg Phe Gln Glu Ala Ile Asp Asn Leu Ala 2135 2140 2145 Val Leu Met Arg Ala Glu Thr Gly Ser Arg Pro Tyr Lys Ala Ala 2150 2155 2160 Ala Ala Gln Leu Pro Glu Thr Leu Glu Thr Ile Met Leu Leu Gly 2165 2170 2175 Leu Leu Gly Thr Val Ser Leu Gly Ile Phe Phe Val Leu Met Arg 2180 2185 2190 Asn Lys Gly Ile Gly Lys Met Gly Phe Gly Met Val Thr Leu Gly 2195 2200 2205 Ala Ser Ala Trp Leu Met Trp Leu Ser Glu Ile Glu Pro Ala Arg 2210 2215 2220 Ile Ala Cys Val Leu Ile Val Val Phe Leu Leu Leu Val Val Leu 2225 2230 2235 Ile Pro Glu Pro Glu Lys Gln Arg Ser Pro Gln Asp Asn Gln Met 2240 2245 2250 Ala Ile Ile Ile Met Val Ala Val Gly Leu Leu Gly Leu Ile Thr 2255 2260 2265 Ala Asn Glu Leu Gly Trp Leu Glu Arg Thr Lys Asn Asp Ile Ala 2270 2275 2280 His Leu Met Gly Arg Arg Glu Glu Gly Ala Thr Met Gly Phe Ser 2285 2290 2295 Met Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp Ala Ile Tyr Ala 2300 2305 2310 Ala Leu Thr Thr Leu Ile Thr Pro Ala Val Gln His Ala Val Thr 2315 2320 2325 Thr Ser Tyr Asn Asn Tyr Ser Leu Met Ala Met Ala Thr Gln Ala 2330 2335 2340 Gly Val Leu Phe Gly Met Gly Lys Gly Met Pro Phe Tyr Ala Trp 2345 2350 2355 Asp Leu Gly Val Pro Leu Leu Met Met Gly Cys Tyr Ser Gln Leu 2360 2365 2370 Thr Pro Leu Thr Leu Ile Val Ala Ile Ile Leu Leu Val Ala His 2375 2380 2385 Tyr Met Tyr Leu Ile Pro Gly Leu Gln Ala Ala Ala Ala Arg Ala 2390 2395 2400 Ala Gln Lys Arg Thr Ala Ala Gly Ile Met Lys Asn Pro Val Val 2405 2410 2415 Asp Gly Ile Val Val Thr Asp Ile Asp Thr Met Thr Ile Asp Pro 2420 2425 2430 Gln Val Glu Lys Lys Met Gly Gln Val Leu Leu Ile Ala Val Ala 2435 2440 2445 Ile Ser Ser Ala Val Leu Leu Arg Thr Ala Trp Gly Trp Gly Glu 2450 2455 2460 Ala Gly Ala Leu Ile Thr Ala Ala Thr Ser Thr Leu Trp Glu Gly 2465 2470 2475 Ser Pro Asn Lys Tyr Trp Asn Ser Ser Thr Ala Thr Ser Leu Cys 2480 2485 2490 Asn Ile Phe Arg Gly Ser Tyr Leu Ala Gly Ala Ser Leu Ile Tyr 2495 2500 2505 Thr Val Thr Arg Asn Ala Gly Leu Val Lys Arg Arg Gly Gly Gly 2510 2515 2520 Thr Gly Glu Thr Leu Gly Glu Lys Trp Lys Ala Arg Leu Asn Gln 2525 2530 2535 Met Ser Ala Leu Glu Phe Tyr Ser Tyr Lys Lys Ser Gly Ile Thr 2540 2545 2550 Glu Val Cys Arg Glu Glu Ala Arg Arg Ala Leu Lys Asp Gly Val 2555 2560 2565 Ala Thr Gly Gly His Ala Val Ser Arg Gly Ser Ala Lys Leu Arg 2570 2575 2580 Trp Leu Val Glu Arg Gly Tyr Leu Gln Pro Tyr Gly Lys Val Val 2585 2590 2595 Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Ala Ala Thr 2600 2605 2610 Ile Arg Lys Val Gln Glu Val Arg Gly Tyr Thr Lys Gly Gly Pro 2615 2620 2625 Gly His Glu Glu Pro Met Leu Val Gln Ser Tyr Gly Trp Asn Ile 2630 2635 2640 Val Arg Leu Lys Ser Gly Val Asp Val Phe His Met Ala Ala Glu 2645 2650 2655 Pro Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Ser Ser 2660 2665 2670 Pro Glu Val Glu Glu Thr Arg Thr Leu Arg Val Leu Ser Met Val 2675 2680 2685 Gly Asp Trp Leu Glu Lys Arg Pro Gly Ala Phe Cys Ile Lys Val 2690 2695 2700 Leu Cys Pro Tyr Thr Ser Thr Met Met Glu Thr Met Glu Arg Leu 2705 2710 2715 Gln Arg Arg His Gly Gly Gly Leu Val Arg Val Pro Leu Ser Arg 2720 2725 2730 Asn Ser Thr His Glu Met Tyr Trp Val Ser Gly Ala Lys Ser Asn 2735 2740 2745 Ile Ile Lys Ser Val Ser Thr Thr Ser Gln Leu Leu Leu Gly Arg 2750 2755 2760 Met Asp Gly Pro Arg Arg Pro Val Lys Tyr Glu Glu Asp Val Asn 2765 2770 2775 Leu Gly Ser Gly Thr Arg Ala Val Ala Ser Cys Ala Glu Ala Pro 2780 2785 2790 Asn Met Lys Ile Ile Gly Arg Arg Ile Glu Arg Ile Arg Asn Glu 2795 2800 2805 His Ala Glu Thr Trp Phe Leu Asp Glu Asn His Pro Tyr Arg Thr 2810 2815 2820 Trp Ala Tyr His Gly Ser Tyr Glu Ala Pro Thr Gln Gly Ser Ala 2825 2830 2835 Ser Ser Leu Val Asn Gly Val Val Arg Leu Leu Ser Lys Pro Trp 2840 2845 2850 Asp Val Val Thr Gly Val Thr Gly Ile Ala Met Thr Asp Thr Thr 2855 2860 2865 Pro Tyr Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg 2870 2875 2880 Val Pro Asp Pro Gln Glu Gly Thr Arg Gln Val Met Asn Ile Val 2885 2890 2895 Ser Ser Trp Leu Trp Lys Glu Leu Gly Lys Arg Lys Arg Pro Arg 2900 2905 2910 Val Cys Thr Lys Glu Glu Phe Ile Asn Lys Val Arg Ser Asn Ala 2915 2920 2925 Ala Leu Gly Ala Ile Phe Glu Glu Glu Lys Glu Trp Lys Thr Ala 2930 2935 2940 Val Glu Ala Val Asn Asp Pro Arg Phe Trp Ala Leu Val Asp Arg 2945 2950 2955 Glu Arg Glu His His Leu Arg Gly Glu Cys His Ser Cys Val Tyr 2960 2965 2970 Asn Met Met Gly Lys Arg Glu Lys Lys Gln Gly Glu Phe Gly Lys 2975 2980 2985 Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg 2990 2995 3000 Phe Leu Glu Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp 3005 3010 3015 Met Gly Arg Glu Asn Ser Gly Gly Gly Val Glu Gly Leu Gly Leu 3020 3025 3030 Gln Arg Leu Gly Tyr Ile Leu Glu Glu Met Asn Arg Ala Pro Gly 3035 3040 3045 Gly Lys Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile 3050 3055 3060 Ser Lys Phe Asp Leu Glu Asn Glu Ala Leu Ile Thr Asn Gln Met 3065 3070 3075 Glu Glu Gly His Arg Thr Leu Ala Leu Ala Val Ile Lys Tyr Thr 3080 3085 3090 Tyr Gln Asn Lys Val Val Lys Val Leu Arg Pro Ala Glu Gly Gly 3095 3100 3105 Lys Thr Val Met Asp Ile Ile Ser Arg Gln Asp Gln Arg Gly Ser 3110 3115 3120 Gly Gln Val Val Thr Tyr Ala Leu Asn Thr Phe Thr Asn Leu Val 3125 3130 3135 Val Gln Leu Ile Arg Asn Met Glu Ala Glu Glu Val Leu Glu Met 3140 3145 3150 Gln Asp Leu Trp Leu Leu Arg Lys Pro Glu Lys Val Thr Arg Trp 3155 3160 3165 Leu Gln Ser Asn Gly Trp Asp Arg Leu Lys Arg Met Ala Val Ser 3170 3175 3180 Gly Asp Asp Cys Val Val Lys Pro Ile Asp Asp Arg Phe Ala His 3185 3190 3195 Ala Leu Arg Phe Leu Asn Asp Met Gly Lys Val Arg Lys Asp Thr 3200 3205 3210 Gln Glu Trp Lys Pro Ser Thr Gly Trp Ser Asn Trp Glu Glu Val 3215 3220 3225 Pro Phe Cys Ser His His Phe Asn Lys Leu Tyr Leu Lys Asp Gly 3230 3235 3240 Arg Ser Ile Val Val Pro Cys Arg His Gln Asp Glu Leu Ile Gly 3245 3250 3255 Arg Ala Arg Val Ser Pro Gly Ala Gly Trp Ser Ile Arg Glu Thr 3260 3265 3270 Ala Cys Leu Ala Lys Ser Tyr Ala Gln Met Trp Gln Leu Leu Tyr 3275 3280 3285 Phe His Arg Arg Asp Leu Arg Leu Met Ala Asn Ala Ile Cys Ser 3290 3295 3300 Ala Val Pro Val Asp Trp Val Pro Thr Gly Arg Thr Thr Trp Ser 3305 3310 3315 Ile His Gly Lys Gly Glu Trp Met Thr Thr Glu Asp Met Leu Met 3320 3325 3330 Val Trp Asn Arg Val Trp Ile Glu Glu Asn Asp His Met Glu Asp 3335 3340 3345 Lys Thr Pro Val Thr Lys Trp Thr Asp Ile Pro Tyr Leu Gly Lys 3350 3355 3360 Arg Glu Asp Leu Trp Cys Gly Ser Leu Ile Gly His Arg Pro Arg 3365 3370 3375 Thr Thr Trp Ala Glu Asn Ile Lys Asp Thr Val Asn Met Val Arg 3380 3385 3390 Arg Ile Ile Gly Asp Glu Glu Lys Tyr Met Asp Tyr Leu Ser Thr 3395 3400 3405 Gln Val Arg Tyr Leu Gly Glu Glu Gly Ser Thr Pro Gly Val Leu 3410 3415 3420 <210> 7 <211> 10269 <212> ÄÍÊ <213> Çèêà øòàìì FSS13025 <220> <221> èíîé ïðèçíàê <222> (4429)..(4429) <223> n is a, c, g, t or u <220> <221> èíîé ïðèçíàê <222> (6882)..(6882) <223> n is a, c, g, t or u <400> 7 atgaaaaacc caaagaagaa atccggagga ttccggattg tcaatatgct aaaacgcgga 60 gtagcccgtg tgagcccctt tgggggcttg aagaggctgc cagccggact tctgctgggt 120 catgggccca tcaggatggt cttggcgatt ctagcctttt tgagattcac ggcaatcaag 180 ccatcactgg gtctcatcaa tagatggggt tcagtgggga aaaaagaggc tatggaaata 240 ataaagaagt ttaagaaaga tctggctgcc atgctgagaa taatcaatgc taggaaggag 300 aagaagagac gaggcacaga tactagtgtc ggaattgttg gcctcctgct gaccacagcc 360 atggcagtgg aggtcactag acgtgggaat gcatactata tgtacttgga cagaagcgat 420 gctggggagg ccatatcttt tccaaccaca atggggatga ataagtgtta tatacagatc 480 atggatcttg gacacatgtg tgatgccacc atgagctatg aatgccctat gctggatgag 540 ggggtagaac cagatgacgt cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac 600 ggaacctgcc accacaaaaa aggtgaagca cggagatcta gaagagctgt gacgctcccc 660 tcccattcca ctaggaagct gcaaacgcgg tcgcagacct ggttggaatc aagagaatac 720 acaaagcacc tgattagagt cgaaaattgg atattcagga accctggctt cgcgttagca 780 gcagctgcca tcgcttggct tttgggaagc tcaacgagcc aaaaagtcat atacttggtc 840 atgatactgc tgattgcccc ggcatacagc atcaggtgca taggagtcag caatagggac 900 tttgtggaag gtatgtcagg tgggacttgg gttgatgttg tcttggaaca tggaggttgt 960 gttaccgtaa tggcacagga caaaccgact gtcgacatag agctggttac aacaacagtc 1020 agcaacatgg cggaggtaag atcctactgc tatgaggcat caatatcgga catggcttcg 1080 gacagccgct gcccaacaca aggtgaagcc taccttgaca agcaatcaga cactcaatat 1140 gtctgcaaaa gaacgttagt ggacagaggc tggggaaatg gatgtggact ttttggcaaa 1200 gggagcctgg tgacatgcgc taagtttgct tgctctaaga aaatgaccgg gaagagcatc 1260 cagccagaga atctggagta ccggataatg ctgtcagttc atggctccca gcacagtggg 1320 atgatcgtta atgatacagg acatgaaact gatgagaata gagcgaaggt tgagataacg 1380 cccaattcac caagagccga agccaccctg gggggttttg gaagcctagg acttgattgt 1440 gaaccgagga caggccttga cttttcagat ttgtattact tgactatgaa taacaagcac 1500 tggttggttc acaaggagtg gttccacgac attccattac cttggcatgc tggggcagac 1560 accggaactc cacactggaa caacaaagaa gcactggtag agttcaagga cgcacatgcc 1620 aaaaggcaga ctgtcgtggt tctagggagt caagaaggag cagttcacac ggcccttgct 1680 ggagctctgg aggctgagat ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa 1740 tgtcgcctga aaatggataa acttagattg aagggcgtgt catactcctt gtgtaccgca 1800 gcgttcacat tcactaagat cccggctgaa acactgcacg ggacagtcac agtggaggta 1860 cagtacgcag ggacagatgg accttgcaag gttccagctc agatggcggt ggacatgcaa 1920 actctgaccc cagttgggag gttgataacc gctaaccctg taatcactga aagcactgag 1980 aactccaaga tgatgctgga actggatcca ccatttgggg actcttacat tgtcatagga 2040 gtcggggaaa agaagatcac ccaccactgg cacaggagtg gcagcaccat tggaaaagca 2100 tttgaagcca ctgtgagagg tgccaagaga atggcagtct tgggagacac agcctgggac 2160 tttggatcag ttgggggtgc tctcaactca ctgggcaagg gcatccatca aatttttgga 2220 gcagctttca aatcattgtt tggaggaatg tcctggttct cacaaattct cattggaacg 2280 ttgctggtgt ggttgggtct gaatacaaag aatggatcta tttcccttat gtgcttggcc 2340 ttagggggag tgttgatctt cttatccaca gccgtctctg ctgatgtggg gtgctcggtg 2400 gacttctcaa agaaggaaac gagatgcggt acaggggtgt tcgtctataa cgacgttgaa 2460 gcttggaggg acaggtacaa gtaccatcct gactcccctc gtagattggc agcagcagtc 2520 aagcaagcct gggaagatgg gatctgtggg atctcctctg tttcaagaat ggaaaacatc 2580 atgtggagat cagtagaagg ggagctcaac gcaatcctgg aagagaatgg agttcaactg 2640 acggtcgttg tgggatctgt aaaaaacccc atgtggagag gtccacagag attgcccgtg 2700 cctgtgaacg agctgcccca tggctggaag gcttggggga aatcgtactt cgtcagggca 2760 gcaaagacaa ataacagctt tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa 2820 catagagcat ggaacagctt tcttgtggag gatcatgggt tcggggtatt tcacactagt 2880 gtctggctca aggttagaga agattattca ttagagtgtg atccagccgt cattggaaca 2940 gccgctaagg gaaaggaggc tgtgcacagt gatctaggct actggattga gagtgagaag 3000 aacgacacat ggaggctgaa gagggcccac ctgatcgaga tgaaaacatg tgaatggcca 3060 aagtcccaca cattgtggac agatggaata gaagaaagtg atctgatcat acccaagtct 3120 ttagctgggc cactcagcca tcacaacacc agagagggct acaggaccca aatgaaaggg 3180 ccatggcata gtgaagagct tgaaattcgg tttgaggaat gcccaggcac taaggtccac 3240 gtggaggaaa catgtggaac aagaggacca tctctgagat caaccactgc aagcggaagg 3300 gtgatcgagg aatggtgctg cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa 3360 gatggttgtt ggtatggaat ggagataagg cccaggaaag aaccagaaag taacttagta 3420 aggtcaatgg tgactgcagg atcaactgat cacatggatc acttctccct tggagtgctt 3480 gtgattctgc tcatggtaca ggaagggcta aagaagagaa tgaccacaaa gatcatcata 3540 agcacatcaa tggcagtgct ggtagctatg atcctgggag gattttcaat gagtgacctg 3600 gctaagcttg caattttgat gggtgccacc ttcgcggaaa tgaacactgg aggagatgtt 3660 gctcatctgg cgctgatagc ggcattcaaa gtcagacctg cgttgctggt atctttcatt 3720 ttcagagcta attggacacc ccgtgagagc atgctgctgg ccttggcctc gtgtcttctg 3780 caaactgcga tctccgcctt ggaaggcgac ctgatggttc ccatcaatgg ttttgctttg 3840 gcctggttgg caatacgagc gatggttgtt ccacgcactg acaacatcac cttggcaatc 3900 ctggctgctc tgacaccact ggcccggggc acactgcttg tggcgtggag agcaggcctt 3960 gctacttgcg gggggttcat gctcctttct ctgaagggga aaggcagtgt gaagaagaac 4020 ttaccatttg tcatggccct gggactaacc gctgtgaggc tggtcgaccc catcaacgtg 4080 gtgggactgc tgttgctcac aaggagtggg aagcggagct ggccccctag tgaagtactc 4140 acagctgttg gcctgatatg cgcattggct ggagggttcg ccaaggcgga tatagagatg 4200 gctgggccca tggccgcggt cggtctgcta attgtcagtt acgtggtctc aggaaagagt 4260 gtggacatgt acattgaaag agcaggtgac atcacatggg aaaaagatgc ggaagtcact 4320 ggaaacagtc cccggctcga tgtggcacta gatgagagtg gtgatttctc cctagtggag 4380 gatgatggtc cccccatgag agagatcata ctcaaagtgg tcctgatgnc catctgtggc 4440 atgaacccaa tagccatacc ctttgcagct ggagcgtggt acgtgtatgt gaagactgga 4500 aaaaggagtg gtgctctatg ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc 4560 acagatggag tgtacagagt aatgactcgt agactgctag gttcaacaca agttggagtg 4620 ggagtcatgc aagagggggt cttccacact atgtggcacg tcacaaaagg atccgcgctg 4680 agaagcggtg aagggagact tgatccatac tggggagatg tcaagcagga tctggtgtca 4740 tactgtggtc catggaagct agatgccgcc tgggacgggc acagcgaggt gcagctcttg 4800 gccgtgcccc ccggagagag agcgaggaac atccagactc tgcccggaat atttaagaca 4860 aaggatgggg acattggagc agttgcgctg gactacccag caggaacttc aggatctcca 4920 atcctagata agtgtgggag agtgatagga ctctatggta atggggtcgt gatcaaaaat 4980 gggagttacg ttagtgccat cacccaaggg aggagggagg aagagactcc tgttgagtgc 5040 ttcgagcctt cgatgctgaa gaagaagcag ctaactgtct tagacttgca tcctggagct 5100 gggaaaacca ggagagttct tcctgaaata gtccgtgaag ccataaaaac aagactccgc 5160 actgtgatct tagctccaac cagggttgtc gctgctgaaa tggaggaagc ccttagaggg 5220 cttccagtgc gttatatgac aacagcagtc aatgtcaccc attctgggac agaaatcgtt 5280 gacttaatgt gccatgccac cttcacttca cgtctactac agccaatcag agtccccaac 5340 tataatctgt atattatgga tgaggcccac ttcacagatc cctcaagtat agcagcaaga 5400 ggatacattt caacaagggt tgagatgggc gaggcggctg ccatcttcat gactgccacg 5460 ccaccaggaa cccgtgacgc attcccggac tccaactcac caattatgga caccgaagtg 5520 gaagtcccag agagagcctg gagctcaggc tttgattggg tgacggatca ttctggaaaa 5580 acagtttggt ttgttccaag cgtgaggaat ggcaatgaga tcgcagcttg tctgacaaag 5640 gctggaaaac gggtcataca gctcagcaga aagacttttg agacagagtt ccagaaaaca 5700 aaacatcaag agtgggactt cgtcgtgaca actgacattt cagagatggg cgccaacttt 5760 aaagctgacc gtgtcataga ttccaggaga tgcctaaagc cggtcatact tgatggcgag 5820 agagtcattc tggctggacc catgcctgtc acacatgcca gcgctgccca gaggaggggg 5880 cgcataggca ggaaccccaa caaacctgga gatgagtatc tgtatggagg tgggtgcgca 5940 gagactgatg aagaccatgc acactggctt gaagcaagaa tgcttcttga caacatttac 6000 ctccaagatg gcctcatagc ctcgctctat cgacctgagg ccgacaaagt agcagctatt 6060 gagggagagt tcaagcttag gacggagcaa aggaagacct ttgtggaact catgaaaaga 6120 ggagatcttc ctgtttggct ggcctatcag gttgcatctg ccggaataac ctacacagat 6180 agaagatggt gctttgatgg cacgaccaac aacaccataa tggaagacag tgtgccggca 6240 gaggtgtgga ccagatacgg agagaaaaga gtgctcaaac cgaggtggat ggacgccaga 6300 gtttgttcag atcatgcggc cctgaagtca ttcaaagagt ttgccgctgg gaaaagagga 6360 gcggcctttg gagtgatgga agccctggga acactgccag gacatatgac agagagattc 6420 caggaggcca ttgacaacct cgctgtgctc atgcgggcag agactggaag caggccctac 6480 aaagccgcgg cggcccaatt accggagacc ctagagacta tcatgctttt ggggttgctg 6540 ggaacagtct cgctgggaat ctttttcgtc ttgatgcgga acaagggcat agggaagatg 6600 ggctttggaa tggtgactct tggggccagc gcatggctta tgtggctctc ggaaattgag 6660 ccagccagaa ttgcatgtgt cctcattgtt gtgttcctat tgctggtggt gctcatacct 6720 gagccagaaa agcaaagatc tccccaggac aaccaaatgg caatcatcat catggtagca 6780 gtgggtcttc tgggcttgat taccgccaat gaactcggat ggttggagag aacaaagagt 6840 gacctaagcc atctaatggg aaggagagag gagggggcaa cnataggatt ctcaatggac 6900 attgacctgc ggccagcctc agcttgggct atctatgctg ctctgacaac tttcattacc 6960 ccagccgtcc aacatgcagt gaccacttca tacaacaact actccttaat ggcgatggcc 7020 acgcaagctg gagtgttgtt cggtatgggt aaagggatgc cattctatgc atgggacttt 7080 ggagtcccgc tgctaatgat aggttgctac tcacaattaa cacccctgac cctaatagtg 7140 gccatcattt tgctcgtggc gcactacatg tacttgatcc cagggctgca ggcagcagct 7200 gcgcgtgctg cccagaagag aacggcagct ggcatcatga agaaccctgt tgtggatgga 7260 atagtggtga ctgacattga cacaatgaca attgaccccc aagtggagaa aaagatggga 7320 caggtgctac tcatagcagt agctgtctcc agcgccatac tgtcgcggac cgcctggggg 7380 tggggtgagg ctggggccct gatcacagct gcaacttcca ctttgtggga gggctctccg 7440 aacaagtact ggaactcctc cacagccacc tcactgtgta acatttttag gggaagctac 7500 ttggctggag cttctctaat ctacacagta acaagaaacg ctggcttggt caagagacgt 7560 gggggtggaa cgggagagac cctgggagag aaatggaagg cccgcctgaa ccagatgtcg 7620 gccctggagt tctactccta caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc 7680 cgccgcgccc tcaaggacgg tgtggcaacg ggaggccacg ctgtgtcccg aggaagtgca 7740 aagctgagat ggttggtgga gaggggatac ctgcagccct atggaaaggt cattgatctt 7800 ggatgtggca gagggggctg gagttactat gccgccacca tccgcaaagt tcaagaagtg 7860 aaaggataca caaaaggagg ccctggtcat gaagaaccca tgttggtgca aagctatggg 7920 tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt 7980 gacacgttgc tgtgtgatat aggtgagtca tcatctagtc ctgaagtgga agaagcacgg 8040 acgctcagag tcctctccat ggtgggggat tggcttgaaa aaagaccagg agccttttgt 8100 ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt 8160 aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac 8220 tgggtctctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctt 8280 ttggggcgca tggacgggcc caggaggcca gtgaaatatg aagaggatgt gaatctcggc 8340 tctggcacgc gggctgtggt aagctgcgct gaagctccca acatgaagat cattggtaac 8400 cgcattgaga ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca 8460 tataggacat gggcttacca tggaagctac gaggccccca cacaagggtc agcgtcctct 8520 ctaataaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca 8580 ggaatagcca tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg 8640 gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc 8700 tggttgtgga aagagttagg caaacacaaa cggccacgag tctgtaccaa agaagagttc 8760 atcaacaagg ttcgtagcaa cgcagcatta ggggcaatat ttgaagagga aaaagagtgg 8820 aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga 8880 gagcaccacc tgagaggaga gtgccagagc tgtgtgtaca acatgatggg aaaaagagaa 8940 aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta catgtggcta 9000 ggggctagat ttctagagtt cgaagccctt ggattcttga acgaggatca ctggatgggg 9060 agagagaatt caggaggtgg tgttgaaggg ctaggattac aaagactcgg atatgtctta 9120 gaagagatga gtcgcatacc aggaggaagg atgtatgcag atgatactgc tggctgggac 9180 acccgcatca gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa 9240 gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag 9300 gtccttagac cagctgaaaa agggaagaca gttatggaca ttatttcaag acaagaccaa 9360 agggggagcg gacaagttgt cacttacgct cttaatacat ttaccaacct agtggtgcag 9420 ctcattcgga atatggaggc tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg 9480 aggtcagaga aagtgaccaa ctggttgcag agcaatggat gggataggct caaacgaatg 9540 gcagtcagtg gagatgattg cgttgtgaaa ccaattgatg ataggtttgc acatgctctc 9600 aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa gccctcaact 9660 ggatgggaca actgggaaga agttccgttt tgctcccacc acttcaacaa gctccatctc 9720 aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgagct 9780 cgcgtctcac cgggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat 9840 gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc 9900 atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat 9960 ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt 10020 gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat 10080 ttgggaaaaa gggaagactt gtggtgtggg tctctcatag ggcacagacc gcgcaccacc 10140 tgggctgaga acattaaaaa cacagtcaac atgatgcgta ggatcatagg tgatgaagaa 10200 aagtacgtgg actacctatc cacccaagtt cgctacttgg gcgaagaagg gtccacacct 10260 ggagtgcta 10269 <210> 8 <211> 3423 <212> PRT <213> Ïîëíûé ORF, Çèêà øòàìì FSS13025 <400> 8 Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 1 5 10 15 Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 20 25 30 Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 35 40 45 Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 50 55 60 Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 65 70 75 80 Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 85 90 95 Ala Arg Lys Glu Lys Lys Arg Arg Gly Thr Asp Thr Ser Val Gly Ile 100 105 110 Val Gly Leu Leu Leu Thr Thr Ala Met Ala Val Glu Val Thr Arg Arg 115 120 125 Gly Asn Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Glu Ala 130 135 140 Ile Ser Phe Pro Thr Thr Met Gly Met Asn Lys Cys Tyr Ile Gln Ile 145 150 155 160 Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 165 170 175 Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 180 185 190 Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 195 200 205 Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 210 215 220 Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 225 230 235 240 Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 245 250 255 Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 260 265 270 Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 275 280 285 Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 290 295 300 Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 305 310 315 320 Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 325 330 335 Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 340 345 350 Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 355 360 365 Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 370 375 380 Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 385 390 395 400 Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 405 410 415 Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 420 425 430 Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 435 440 445 Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 450 455 460 Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 465 470 475 480 Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 485 490 495 Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 500 505 510 Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 515 520 525 Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 530 535 540 Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 545 550 555 560 Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 565 570 575 Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 580 585 590 Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 595 600 605 Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 610 615 620 Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 625 630 635 640 Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 645 650 655 Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 660 665 670 Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 675 680 685 His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 690 695 700 Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 705 710 715 720 Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 725 730 735 Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 740 745 750 Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn 755 760 765 Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 770 775 780 Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 785 790 795 800 Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 805 810 815 Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 820 825 830 Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 835 840 845 Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 850 855 860 Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 865 870 875 880 Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 885 890 895 Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 900 905 910 Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 915 920 925 Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 930 935 940 Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 945 950 955 960 Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 965 970 975 Val Ile Gly Thr Ala Ala Lys Gly Lys Glu Ala Val His Ser Asp Leu 980 985 990 Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg 995 1000 1005 Ala His Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His 1010 1015 1020 Thr Leu Trp Thr Asp Gly Ile Glu Glu Ser Asp Leu Ile Ile Pro 1025 1030 1035 Lys Ser Leu Ala Gly Pro Leu Ser His His Asn Thr Arg Glu Gly 1040 1045 1050 Tyr Arg Thr Gln Met Lys Gly Pro Trp His Ser Glu Glu Leu Glu 1055 1060 1065 Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val Glu Glu 1070 1075 1080 Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser 1085 1090 1095 Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro 1100 1105 1110 Pro Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu 1115 1120 1125 Ile Arg Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met 1130 1135 1140 Val Thr Ala Gly Ser Thr Asp His Met Asp His Phe Ser Leu Gly 1145 1150 1155 Val Leu Val Ile Leu Leu Met Val Gln Glu Gly Leu Lys Lys Arg 1160 1165 1170 Met Thr Thr Lys Ile Ile Ile Ser Thr Ser Met Ala Val Leu Val 1175 1180 1185 Ala Met Ile Leu Gly Gly Phe Ser Met Ser Asp Leu Ala Lys Leu 1190 1195 1200 Ala Ile Leu Met Gly Ala Thr Phe Ala Glu Met Asn Thr Gly Gly 1205 1210 1215 Asp Val Ala His Leu Ala Leu Ile Ala Ala Phe Lys Val Arg Pro 1220 1225 1230 Ala Leu Leu Val Ser Phe Ile Phe Arg Ala Asn Trp Thr Pro Arg 1235 1240 1245 Glu Ser Met Leu Leu Ala Leu Ala Ser Cys Leu Leu Gln Thr Ala 1250 1255 1260 Ile Ser Ala Leu Glu Gly Asp Leu Met Val Pro Ile Asn Gly Phe 1265 1270 1275 Ala Leu Ala Trp Leu Ala Ile Arg Ala Met Val Val Pro Arg Thr 1280 1285 1290 Asp Asn Ile Thr Leu Ala Ile Leu Ala Ala Leu Thr Pro Leu Ala 1295 1300 1305 Arg Gly Thr Leu Leu Val Ala Trp Arg Ala Gly Leu Ala Thr Cys 1310 1315 1320 Gly Gly Phe Met Leu Leu Ser Leu Lys Gly Lys Gly Ser Val Lys 1325 1330 1335 Lys Asn Leu Pro Phe Val Met Ala Leu Gly Leu Thr Ala Val Arg 1340 1345 1350 Leu Val Asp Pro Ile Asn Val Val Gly Leu Leu Leu Leu Thr Arg 1355 1360 1365 Ser Gly Lys Arg Ser Trp Pro Pro Ser Glu Val Leu Thr Ala Val 1370 1375 1380 Gly Leu Ile Cys Ala Leu Ala Gly Gly Phe Ala Lys Ala Asp Ile 1385 1390 1395 Glu Met Ala Gly Pro Met Ala Ala Val Gly Leu Leu Ile Val Ser 1400 1405 1410 Tyr Val Val Ser Gly Lys Ser Val Asp Met Tyr Ile Glu Arg Ala 1415 1420 1425 Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser 1430 1435 1440 Pro Arg Leu Asp Val Ala Leu Asp Glu Ser Gly Asp Phe Ser Leu 1445 1450 1455 Val Glu Asp Asp Gly Pro Pro Met Arg Glu Ile Ile Leu Lys Val 1460 1465 1470 Val Leu Met Ala Ile Cys Gly Met Asn Pro Ile Ala Ile Pro Phe 1475 1480 1485 Ala Ala Gly Ala Trp Tyr Val Tyr Val Lys Thr Gly Lys Arg Ser 1490 1495 1500 Gly Ala Leu Trp Asp Val Pro Ala Pro Lys Glu Val Lys Lys Gly 1505 1510 1515 Glu Thr Thr Asp Gly Val Tyr Arg Val Met Thr Arg Arg Leu Leu 1520 1525 1530 Gly Ser Thr Gln Val Gly Val Gly Val Met Gln Glu Gly Val Phe 1535 1540 1545 His Thr Met Trp His Val Thr Lys Gly Ser Ala Leu Arg Ser Gly 1550 1555 1560 Glu Gly Arg Leu Asp Pro Tyr Trp Gly Asp Val Lys Gln Asp Leu 1565 1570 1575 Val Ser Tyr Cys Gly Pro Trp Lys Leu Asp Ala Ala Trp Asp Gly 1580 1585 1590 His Ser Glu Val Gln Leu Leu Ala Val Pro Pro Gly Glu Arg Ala 1595 1600 1605 Arg Asn Ile Gln Thr Leu Pro Gly Ile Phe Lys Thr Lys Asp Gly 1610 1615 1620 Asp Ile Gly Ala Val Ala Leu Asp Tyr Pro Ala Gly Thr Ser Gly 1625 1630 1635 Ser Pro Ile Leu Asp Lys Cys Gly Arg Val Ile Gly Leu Tyr Gly 1640 1645 1650 Asn Gly Val Val Ile Lys Asn Gly Ser Tyr Val Ser Ala Ile Thr 1655 1660 1665 Gln Gly Arg Arg Glu Glu Glu Thr Pro Val Glu Cys Phe Glu Pro 1670 1675 1680 Ser Met Leu Lys Lys Lys Gln Leu Thr Val Leu Asp Leu His Pro 1685 1690 1695 Gly Ala Gly Lys Thr Arg Arg Val Leu Pro Glu Ile Val Arg Glu 1700 1705 1710 Ala Ile Lys Thr Arg Leu Arg Thr Val Ile Leu Ala Pro Thr Arg 1715 1720 1725 Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu Pro Val 1730 1735 1740 Arg Tyr Met Thr Thr Ala Val Asn Val Thr His Ser Gly Thr Glu 1745 1750 1755 Ile Val Asp Leu Met Cys His Ala Thr Phe Thr Ser Arg Leu Leu 1760 1765 1770 Gln Pro Ile Arg Val Pro Asn Tyr Asn Leu Tyr Ile Met Asp Glu 1775 1780 1785 Ala His Phe Thr Asp Pro Ser Ser Ile Ala Ala Arg Gly Tyr Ile 1790 1795 1800 Ser Thr Arg Val Glu Met Gly Glu Ala Ala Ala Ile Phe Met Thr 1805 1810 1815 Ala Thr Pro Pro Gly Thr Arg Asp Ala Phe Pro Asp Ser Asn Ser 1820 1825 1830 Pro Ile Met Asp Thr Glu Val Glu Val Pro Glu Arg Ala Trp Ser 1835 1840 1845 Ser Gly Phe Asp Trp Val Thr Asp His Ser Gly Lys Thr Val Trp 1850 1855 1860 Phe Val Pro Ser Val Arg Asn Gly Asn Glu Ile Ala Ala Cys Leu 1865 1870 1875 Thr Lys Ala Gly Lys Arg Val Ile Gln Leu Ser Arg Lys Thr Phe 1880 1885 1890 Glu Thr Glu Phe Gln Lys Thr Lys His Gln Glu Trp Asp Phe Val 1895 1900 1905 Val Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe Lys Ala Asp 1910 1915 1920 Arg Val Ile Asp Ser Arg Arg Cys Leu Lys Pro Val Ile Leu Asp 1925 1930 1935 Gly Glu Arg Val Ile Leu Ala Gly Pro Met Pro Val Thr His Ala 1940 1945 1950 Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg Asn Pro Asn Lys 1955 1960 1965 Pro Gly Asp Glu Tyr Leu Tyr Gly Gly Gly Cys Ala Glu Thr Asp 1970 1975 1980 Glu Asp His Ala His Trp Leu Glu Ala Arg Met Leu Leu Asp Asn 1985 1990 1995 Ile Tyr Leu Gln Asp Gly Leu Ile Ala Ser Leu Tyr Arg Pro Glu 2000 2005 2010 Ala Asp Lys Val Ala Ala Ile Glu Gly Glu Phe Lys Leu Arg Thr 2015 2020 2025 Glu Gln Arg Lys Thr Phe Val Glu Leu Met Lys Arg Gly Asp Leu 2030 2035 2040 Pro Val Trp Leu Ala Tyr Gln Val Ala Ser Ala Gly Ile Thr Tyr 2045 2050 2055 Thr Asp Arg Arg Trp Cys Phe Asp Gly Thr Thr Asn Asn Thr Ile 2060 2065 2070 Met Glu Asp Ser Val Pro Ala Glu Val Trp Thr Arg Tyr Gly Glu 2075 2080 2085 Lys Arg Val Leu Lys Pro Arg Trp Met Asp Ala Arg Val Cys Ser 2090 2095 2100 Asp His Ala Ala Leu Lys Ser Phe Lys Glu Phe Ala Ala Gly Lys 2105 2110 2115 Arg Gly Ala Ala Phe Gly Val Met Glu Ala Leu Gly Thr Leu Pro 2120 2125 2130 Gly His Met Thr Glu Arg Phe Gln Glu Ala Ile Asp Asn Leu Ala 2135 2140 2145 Val Leu Met Arg Ala Glu Thr Gly Ser Arg Pro Tyr Lys Ala Ala 2150 2155 2160 Ala Ala Gln Leu Pro Glu Thr Leu Glu Thr Ile Met Leu Leu Gly 2165 2170 2175 Leu Leu Gly Thr Val Ser Leu Gly Ile Phe Phe Val Leu Met Arg 2180 2185 2190 Asn Lys Gly Ile Gly Lys Met Gly Phe Gly Met Val Thr Leu Gly 2195 2200 2205 Ala Ser Ala Trp Leu Met Trp Leu Ser Glu Ile Glu Pro Ala Arg 2210 2215 2220 Ile Ala Cys Val Leu Ile Val Val Phe Leu Leu Leu Val Val Leu 2225 2230 2235 Ile Pro Glu Pro Glu Lys Gln Arg Ser Pro Gln Asp Asn Gln Met 2240 2245 2250 Ala Ile Ile Ile Met Val Ala Val Gly Leu Leu Gly Leu Ile Thr 2255 2260 2265 Ala Asn Glu Leu Gly Trp Leu Glu Arg Thr Lys Ser Asp Leu Ser 2270 2275 2280 His Leu Met Gly Arg Arg Glu Glu Gly Ala Thr Ile Gly Phe Ser 2285 2290 2295 Met Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp Ala Ile Tyr Ala 2300 2305 2310 Ala Leu Thr Thr Phe Ile Thr Pro Ala Val Gln His Ala Val Thr 2315 2320 2325 Thr Ser Tyr Asn Asn Tyr Ser Leu Met Ala Met Ala Thr Gln Ala 2330 2335 2340 Gly Val Leu Phe Gly Met Gly Lys Gly Met Pro Phe Tyr Ala Trp 2345 2350 2355 Asp Phe Gly Val Pro Leu Leu Met Ile Gly Cys Tyr Ser Gln Leu 2360 2365 2370 Thr Pro Leu Thr Leu Ile Val Ala Ile Ile Leu Leu Val Ala His 2375 2380 2385 Tyr Met Tyr Leu Ile Pro Gly Leu Gln Ala Ala Ala Ala Arg Ala 2390 2395 2400 Ala Gln Lys Arg Thr Ala Ala Gly Ile Met Lys Asn Pro Val Val 2405 2410 2415 Asp Gly Ile Val Val Thr Asp Ile Asp Thr Met Thr Ile Asp Pro 2420 2425 2430 Gln Val Glu Lys Lys Met Gly Gln Val Leu Leu Ile Ala Val Ala 2435 2440 2445 Val Ser Ser Ala Ile Leu Ser Arg Thr Ala Trp Gly Trp Gly Glu 2450 2455 2460 Ala Gly Ala Leu Ile Thr Ala Ala Thr Ser Thr Leu Trp Glu Gly 2465 2470 2475 Ser Pro Asn Lys Tyr Trp Asn Ser Ser Thr Ala Thr Ser Leu Cys 2480 2485 2490 Asn Ile Phe Arg Gly Ser Tyr Leu Ala Gly Ala Ser Leu Ile Tyr 2495 2500 2505 Thr Val Thr Arg Asn Ala Gly Leu Val Lys Arg Arg Gly Gly Gly 2510 2515 2520 Thr Gly Glu Thr Leu Gly Glu Lys Trp Lys Ala Arg Leu Asn Gln 2525 2530 2535 Met Ser Ala Leu Glu Phe Tyr Ser Tyr Lys Lys Ser Gly Ile Thr 2540 2545 2550 Glu Val Cys Arg Glu Glu Ala Arg Arg Ala Leu Lys Asp Gly Val 2555 2560 2565 Ala Thr Gly Gly His Ala Val Ser Arg Gly Ser Ala Lys Leu Arg 2570 2575 2580 Trp Leu Val Glu Arg Gly Tyr Leu Gln Pro Tyr Gly Lys Val Ile 2585 2590 2595 Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Ala Ala Thr 2600 2605 2610 Ile Arg Lys Val Gln Glu Val Lys Gly Tyr Thr Lys Gly Gly Pro 2615 2620 2625 Gly His Glu Glu Pro Met Leu Val Gln Ser Tyr Gly Trp Asn Ile 2630 2635 2640 Val Arg Leu Lys Ser Gly Val Asp Val Phe His Met Ala Ala Glu 2645 2650 2655 Pro Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Ser Ser 2660 2665 2670 Pro Glu Val Glu Glu Ala Arg Thr Leu Arg Val Leu Ser Met Val 2675 2680 2685 Gly Asp Trp Leu Glu Lys Arg Pro Gly Ala Phe Cys Ile Lys Val 2690 2695 2700 Leu Cys Pro Tyr Thr Ser Thr Met Met Glu Thr Leu Glu Arg Leu 2705 2710 2715 Gln Arg Arg Tyr Gly Gly Gly Leu Val Arg Val Pro Leu Ser Arg 2720 2725 2730 Asn Ser Thr His Glu Met Tyr Trp Val Ser Gly Ala Lys Ser Asn 2735 2740 2745 Thr Ile Lys Ser Val Ser Thr Thr Ser Gln Leu Leu Leu Gly Arg 2750 2755 2760 Met Asp Gly Pro Arg Arg Pro Val Lys Tyr Glu Glu Asp Val Asn 2765 2770 2775 Leu Gly Ser Gly Thr Arg Ala Val Val Ser Cys Ala Glu Ala Pro 2780 2785 2790 Asn Met Lys Ile Ile Gly Asn Arg Ile Glu Arg Ile Arg Ser Glu 2795 2800 2805 His Ala Glu Thr Trp Phe Phe Asp Glu Asn His Pro Tyr Arg Thr 2810 2815 2820 Trp Ala Tyr His Gly Ser Tyr Glu Ala Pro Thr Gln Gly Ser Ala 2825 2830 2835 Ser Ser Leu Ile Asn Gly Val Val Arg Leu Leu Ser Lys Pro Trp 2840 2845 2850 Asp Val Val Thr Gly Val Thr Gly Ile Ala Met Thr Asp Thr Thr 2855 2860 2865 Pro Tyr Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg 2870 2875 2880 Val Pro Asp Pro Gln Glu Gly Thr Arg Gln Val Met Ser Met Val 2885 2890 2895 Ser Ser Trp Leu Trp Lys Glu Leu Gly Lys His Lys Arg Pro Arg 2900 2905 2910 Val Cys Thr Lys Glu Glu Phe Ile Asn Lys Val Arg Ser Asn Ala 2915 2920 2925 Ala Leu Gly Ala Ile Phe Glu Glu Glu Lys Glu Trp Lys Thr Ala 2930 2935 2940 Val Glu Ala Val Asn Asp Pro Arg Phe Trp Ala Leu Val Asp Lys 2945 2950 2955 Glu Arg Glu His His Leu Arg Gly Glu Cys Gln Ser Cys Val Tyr 2960 2965 2970 Asn Met Met Gly Lys Arg Glu Lys Lys Gln Gly Glu Phe Gly Lys 2975 2980 2985 Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg 2990 2995 3000 Phe Leu Glu Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp 3005 3010 3015 Met Gly Arg Glu Asn Ser Gly Gly Gly Val Glu Gly Leu Gly Leu 3020 3025 3030 Gln Arg Leu Gly Tyr Val Leu Glu Glu Met Ser Arg Ile Pro Gly 3035 3040 3045 Gly Arg Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile 3050 3055 3060 Ser Arg Phe Asp Leu Glu Asn Glu Ala Leu Ile Thr Asn Gln Met 3065 3070 3075 Glu Lys Gly His Arg Ala Leu Ala Leu Ala Ile Ile Lys Tyr Thr 3080 3085 3090 Tyr Gln Asn Lys Val Val Lys Val Leu Arg Pro Ala Glu Lys Gly 3095 3100 3105 Lys Thr Val Met Asp Ile Ile Ser Arg Gln Asp Gln Arg Gly Ser 3110 3115 3120 Gly Gln Val Val Thr Tyr Ala Leu Asn Thr Phe Thr Asn Leu Val 3125 3130 3135 Val Gln Leu Ile Arg Asn Met Glu Ala Glu Glu Val Leu Glu Met 3140 3145 3150 Gln Asp Leu Trp Leu Leu Arg Arg Ser Glu Lys Val Thr Asn Trp 3155 3160 3165 Leu Gln Ser Asn Gly Trp Asp Arg Leu Lys Arg Met Ala Val Ser 3170 3175 3180 Gly Asp Asp Cys Val Val Lys Pro Ile Asp Asp Arg Phe Ala His 3185 3190 3195 Ala Leu Arg Phe Leu Asn Asp Met Gly Lys Val Arg Lys Asp Thr 3200 3205 3210 Gln Glu Trp Lys Pro Ser Thr Gly Trp Asp Asn Trp Glu Glu Val 3215 3220 3225 Pro Phe Cys Ser His His Phe Asn Lys Leu His Leu Lys Asp Gly 3230 3235 3240 Arg Ser Ile Val Val Pro Cys Arg His Gln Asp Glu Leu Ile Gly 3245 3250 3255 Arg Ala Arg Val Ser Pro Gly Ala Gly Trp Ser Ile Arg Glu Thr 3260 3265 3270 Ala Cys Leu Ala Lys Ser Tyr Ala Gln Met Trp Gln Leu Leu Tyr 3275 3280 3285 Phe His Arg Arg Asp Leu Arg Leu Met Ala Asn Ala Ile Cys Ser 3290 3295 3300 Ser Val Pro Val Asp Trp Val Pro Thr Gly Arg Thr Thr Trp Ser 3305 3310 3315 Ile His Gly Lys Gly Glu Trp Met Thr Thr Glu Asp Met Leu Val 3320 3325 3330 Val Trp Asn Arg Val Trp Ile Glu Glu Asn Asp His Met Glu Asp 3335 3340 3345 Lys Thr Pro Val Thr Lys Trp Thr Asp Ile Pro Tyr Leu Gly Lys 3350 3355 3360 Arg Glu Asp Leu Trp Cys Gly Ser Leu Ile Gly His Arg Pro Arg 3365 3370 3375 Thr Thr Trp Ala Glu Asn Ile Lys Asn Thr Val Asn Met Met Arg 3380 3385 3390 Arg Ile Ile Gly Asp Glu Glu Lys Tyr Val Asp Tyr Leu Ser Thr 3395 3400 3405 Gln Val Arg Tyr Leu Gly Glu Glu Gly Ser Thr Pro Gly Val Leu 3410 3415 3420