СПИСОК ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY INOVIO PHARMACEUTICALS, INC. Weiner, David Muthumani, Kar Chen, Jing Smith, Trevor Schultheis, Katherine <120> КОНСТРУКТЫ АНТИТЕЛ НА ОСНОВЕ НУКЛЕИНОВОЙ КИСЛОТЫ ДЛЯ ИСПОЛЬЗОВАНИЯ ПРОТИВ РЕСПИРАТОРНОГО СИНЦИТИАЛЬНОГО ВИРУСА <130> 206194-0023-00WO <150> 62/624,320 <151> 2018-01-31 <150> 62/749,580 <151> 2018-10-23 <160> 7 <170> Патентная версия 3.5 <210> 1 <211> 5153 <212> ДНК <213> Искусственная последовательность <220> <223> pGX9368 <400> 1 gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta 60 atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata 120 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 180 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 240 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 300 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 360 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 420 gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag 480 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 540 aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga 600 ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga 660 aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt 720 accgagctcg gatccgccac catggactgg acatggagaa tcctgttcct ggtggcagca 780 gcaaccggaa cacacgcaca ggtgaccctg agagagtccg gaccagccct ggtgaagcca 840 acccagacac tgaccctgac atgcaccttc tccggctttt ctctgagcac ctccggcatg 900 tctgtgggat ggatcaggca gccccctggc aaggccctgg agtggctggc cgacatctgg 960 tgggacgata agaaggatta caaccctagc ctgaagtccc gcctgacaat cagcaaggac 1020 acctccaaga accaggtggt gctgaaggtg acaaatatgg acccagccga tacagccacc 1080 tactattgcg cccggagcat gatcaccaat tggtatttcg acgtgtgggg cgccggaacc 1140 acagtgacag tgagctccgc ctccaccaag ggaccaagcg tgttcccact ggcaccctct 1200 agcaagtcta caagcggcgg caccgccgcc ctgggatgtc tggtgaagga ctacttcccc 1260 gagcctgtga ccgtgtcttg gaacagcggc gccctgacat ccggagtgca cacctttcca 1320 gccgtgctgc agtcctctgg cctgtacagc ctgagctccg tggtgacagt gccctctagc 1380 tccctgggca cacagaccta tatctgcaac gtgaatcaca agccctctaa taccaaggtg 1440 gacaagaagg tggagcctaa gagctgtgat aagacacaca cctgcccacc ctgtccagca 1500 ccagagctgc tgggcggccc tagcgtgttc ctgtttcctc caaagccaaa ggacaccctg 1560 atgatctcca gaacacctga ggtgacctgc gtggtggtgg acgtgtctca cgaggacccc 1620 gaggtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcct 1680 cgggaggagc agtacaacag cacatataga gtggtgtccg tgctgaccgt gctgcaccag 1740 gattggctga acggcaagga gtataagtgc aaggtgtcca ataaggccct gcctgcccca 1800 atcgagaaga caatcagcaa ggccaagggc cagcctaggg agccacaggt gtacaccctg 1860 ccccctagcc gcgacgagct gacaaagaac caggtgtccc tgacctgtct ggtgaagggc 1920 ttctatccat ctgatatcgc cgtggagtgg gagagcaatg gccagcccga gaacaattac 1980 aagaccacac cacccgtgct ggactccgat ggctctttct ttctgtattc caagctgacc 2040 gtggacaagt ctaggtggca gcagggcaac gtgttttcct gttctgtgat gcacgaggcc 2100 ctgcacaatc actacacaca gaagagcctg tccctgtctc caggcaagag gggaaggaag 2160 cggagaagcg gctccggagc aaccaacttc tccctgctga agcaggcagg cgatgtggag 2220 gagaatccag gacctatggt gctgcagacc caggtgttta tctctctgct gctgtggatc 2280 agcggcgcct acggcgacat ccagatgaca cagtctccaa gcaccctgtc cgcctctgtg 2340 ggcgataggg tgacaatcac ctgcaagtgt cagctgagcg tgggctacat gcactggtat 2400 cagcagaagc ccggcaaggc ccctaagctg ctgatctacg acacctctaa gctggcaagc 2460 ggagtgccct cccgcttcag cggctccggc tctggaacag agtttacact gaccatctct 2520 agcctgcagc ccgacgattt cgccacctac tattgctttc agggcagcgg ctatcccttc 2580 accttcggcg gcggcaccaa gctggagatc aagcggacag tggccgcccc cagcgtgttc 2640 atctttcctc catccgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg 2700 aacaatttct accctagaga ggccaaggtg cagtggaagg tggataacgc cctgcagagc 2760 ggcaattccc aggagtctgt gacagagcag gacagcaagg attccaccta ttctctgtcc 2820 tctacactga ccctgtccaa ggccgattac gagaagcaca aggtgtatgc ctgcgaggtg 2880 acacaccagg gcctgagctc ccctgtgacc aagagcttta acagaggcga gtgttgataa 2940 ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc 3000 cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc 3060 actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct 3120 attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg 3180 catgctgggg atgcggtggg ctctatggct tctactgggc ggttttatgg acagcaagcg 3240 aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc aaagtaaact 3300 ggatggcttt cttgccgcca aggatctgat ggcgcagggg atcaagctct gatcaagaga 3360 caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg 3420 cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg 3480 ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt 3540 ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg gccacgacgg 3600 gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat 3660 tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat 3720 ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg 3780 accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg 3840 atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc 3900 tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc 3960 cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg 4020 tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg 4080 gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca 4140 tcgccttcta tcgccttctt gacgagttct tctgaattat taacgcttac aatttcctga 4200 tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatcagg tggcactttt 4260 cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat 4320 ccgctcatga gacaataacc ctgataaatg cttcaataat agcacgtgct aaaacttcat 4380 ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 4440 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 4500 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 4560 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 4620 agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc 4680 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 4740 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 4800 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 4860 tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 4920 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 4980 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 5040 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 5100 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctt 5153 <210> 2 <211> 4439 <212> ДНК <213> Искусственная последовательность <220> <223> pGX9369 <400> 2 gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta 60 atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata 120 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 180 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 240 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 300 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 360 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 420 gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag 480 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 540 aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga 600 ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga 660 aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt 720 accgagctcg gatccgccac catggtgctg cagacccagg tgtttatttc actgctgctg 780 tggatttcag gagcctacgg ggacattcag atgacccaga gcccttcaac actgtccgcc 840 agcgtgggcg acagagtgac aatcacctgt aagtgccagc tgagcgtggg ctatatgcac 900 tggtatcagc agaagcctgg caaggcccca aagctgctga tctatgacac cagcaagctg 960 gcctctggcg tgccatccag attctccggc tctggcagcg gcaccgagtt tacactgacc 1020 atctccagcc tgcagccaga tgacttcgcc acctactatt gcttccaggg cagcggctat 1080 cccttcacct ttggcggcgg cacaaagctg gagatcaagg gcggcggcgg ctccggcggc 1140 ggcggctctg gcggcggcgg ctctcaggtg accctgagag agtccggccc agccctggtg 1200 aagccaaccc agaccctgac actgacatgc accttctccg gcttcagcct gtccaccagc 1260 ggcatgtccg tgggctggat caggcagccc ccaggcaagg ccctggagtg gctggccgat 1320 atctggtggg acgataagaa ggactacaac ccctccctga agagcagact gaccatcagc 1380 aaggatacca gcaagaacca ggtggtgctg aaggtgacaa atatggaccc agccgatacc 1440 gccacatact actgtgccag atccatgatc acaaattggt acttcgacgt gtggggcgcc 1500 ggcacaaccg tgacagtgag ctctgagcca aagtcctgcg acaagaccca cacctgtcct 1560 ccttgtccag cccccgagct gctgggcggc ccaagcgtgt tcctgtttcc ccctaagcca 1620 aaggataccc tgatgatctc cagaacccca gaggtgacat gcgtggtggt ggacgtgagc 1680 cacgaggacc ccgaggtgaa gttcaattgg tacgtggatg gcgtggaggt gcacaatgcc 1740 aagaccaagc caagagagga gcagtataac tctacatatc gcgtggtgtc cgtgctgaca 1800 gtgctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtgtc caataaggcc 1860 ctgccagccc ctatcgagaa gacaatctcc aaggccaagg gccagcccag agagccacag 1920 gtgtatacac tgccaccctc cagagatgag ctgacaaaga atcaggtgtc cctgacatgt 1980 ctggtgaagg gcttttatcc ctccgatatc gccgtggagt gggagtctaa tggccagccc 2040 gagaataact ataagacaac ccctccagtg ctggactccg atggctcctt tttcctgtat 2100 tccaagctga ccgtggataa gagcaggtgg cagcagggca acgtgttctc ttgttccgtg 2160 atgcacgaag cactgcacaa ccactacacc cagaagtcac tgtcactgtc accaggaaaa 2220 tgataactcg agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct 2280 agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc 2340 actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt 2400 cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat 2460 agcaggcatg ctggggatgc ggtgggctct atggcttcta ctgggcggtt ttatggacag 2520 caagcgaacc ggaattgcca gctggggcgc cctctggtaa ggttgggaag ccctgcaaag 2580 taaactggat ggctttcttg ccgccaagga tctgatggcg caggggatca agctctgatc 2640 aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac gcaggttctc 2700 cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct 2760 ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg 2820 acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg tggctggcca 2880 cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc 2940 tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga 3000 aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc 3060 cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc 3120 ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg 3180 ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct 3240 gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc 3300 tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc 3360 ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc 3420 agcgcatcgc cttctatcgc cttcttgacg agttcttctg aattattaac gcttacaatt 3480 tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atcaggtggc 3540 acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 3600 atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa 3660 cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa 3720 atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga 3780 tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg 3840 ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact 3900 ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac 3960 cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg 4020 gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg 4080 gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga 4140 acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc 4200 gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg 4260 agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc 4320 tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc 4380 agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttctt 4439 <210> 3 <211> 5153 <212> ДНК <213> Искусственная последовательность <220> <223> pGX9370 <400> 3 gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta 60 atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata 120 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 180 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 240 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 300 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 360 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 420 gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag 480 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 540 aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga 600 ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga 660 aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt 720 accgagctcg gatccgccac catggactgg acctggagaa tcctgttcct ggtggcagca 780 gcaaccggaa cacacgcaca ggtgacactg agggagagcg gacctgccct ggtgaagcca 840 acccagacac tgaccctgac atgcaccttc tctggctttt ccctgtctac cagcggcatg 900 agcgtgggat ggatcaggca gccccctggc aaggccctgg agtggctggc cgacatctgg 960 tgggacgata agaaggatta caacccctct ctgaagagcc gcctgaccat cagcaaggat 1020 acatccaaga accaggtggt gctgaaggtg accaatatgg accctgccga tacagccacc 1080 tactattgtg cccggagcat gatcaccaat tggtactttg acgtgtgggg cgccggcacc 1140 acagtgacag tgagctccgc caagaccaca gccccttccg tgtatcctct ggccccagtg 1200 tgcggcgata ccacaggctc tagcgtgacc ctgggctgtc tggtgaaggg ctacttccca 1260 gagcccgtga cactgacctg gaactccggc tctctgtcct ctggcgtgca cacctttcca 1320 gccgtgctgc agagcgacct gtacacactg agctcctctg tgacagtgac cagctccacc 1380 tggccaagcc agtccatcac atgcaacgtg gcccaccccg cctctagcac caaggtggat 1440 aagaagatcg agcccagagg ccctacaatc aagccctgtc caccctgcaa gtgtcctgcc 1500 ccaaatctgc tgggcggccc ttccgtgttc atctttcctc caaagatcaa ggacgtgctg 1560 atgatctctc tgagccctat cgtgacctgc gtggtggtgg acgtgtccga ggacgatcca 1620 gatgtgcaga tctcttggtt cgtgaacaat gtggaggtgc acaccgccca gacacagacc 1680 caccgggagg attataacag cacactgaga gtggtgtccg ccctgccaat ccagcaccag 1740 gactggatga gcggcaagga gtttaagtgc aaggtgaaca ataaggatct gcccgcccct 1800 atcgagcgga ccatctccaa gcccaagggc tctgtgagag cccctcaggt gtacgtgctg 1860 ccccctccag aggaggagat gaccaagaag caggtgacac tgacctgtat ggtgacagac 1920 ttcatgcctg aggatatcta cgtggagtgg accaacaatg gcaagacaga gctgaactat 1980 aagaataccg agccagtgct ggactccgat ggctcttact ttatgtatag caagctgagg 2040 gtggagaaga agaactgggt ggagcgcaat tcctattctt gtagcgtggt gcacgagggc 2100 ctgcacaatc accacaccac aaagtccttc tctagaaccc caggcaagag gggaaggaag 2160 cggagaagcg gctccggagc cacaaacttt tccctgctga agcaggcagg cgacgtggag 2220 gagaatccag gacccatggt gctgcagacc caggtgttca tctctctgct gctgtggatc 2280 agcggcgcct acggcgacat ccagatgacc cagtctccca gcacactgtc cgcctctgtg 2340 ggcgatcggg tgacaatcac ctgcaagtgt cagctgtccg tgggctacat gcactggtat 2400 cagcagaagc caggcaaggc ccccaagctg ctgatctatg acacctctaa gctggccagc 2460 ggcgtgcctt ccagattcag cggctccggc tctggcaccg agtttacact gaccatctcc 2520 tctctgcagc cagacgattt cgccacatac tattgctttc agggcagcgg ataccccttc 2580 accttcggcg gcggcacaaa gctggagatc aagagggccg atgccgcccc aaccgtgtcc 2640 atcttccctc ccagcagcga gcagctgaca tctggcggcg ccagcgtggt gtgcttcctg 2700 aacaacttct accccaagga catcaacgtg aagtggaaga tcgatggcag cgagcgccag 2760 aacggcgtgc tgaattcctg gaccgaccag gatagcaagg actccacata ctctatgtct 2820 agcacactga ccctgacaaa ggatgagtac gagcggcaca attcctatac ctgcgaggcc 2880 acacacaaga ccagcacatc ccctatcgtg aagtctttta acagaaatga gtgttgataa 2940 ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc 3000 cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc 3060 actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct 3120 attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg 3180 catgctgggg atgcggtggg ctctatggct tctactgggc ggttttatgg acagcaagcg 3240 aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc aaagtaaact 3300 ggatggcttt cttgccgcca aggatctgat ggcgcagggg atcaagctct gatcaagaga 3360 caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg 3420 cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg 3480 ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt 3540 ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg gccacgacgg 3600 gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat 3660 tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat 3720 ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg 3780 accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg 3840 atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc 3900 tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc 3960 cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg 4020 tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg 4080 gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca 4140 tcgccttcta tcgccttctt gacgagttct tctgaattat taacgcttac aatttcctga 4200 tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatcagg tggcactttt 4260 cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat 4320 ccgctcatga gacaataacc ctgataaatg cttcaataat agcacgtgct aaaacttcat 4380 ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 4440 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 4500 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 4560 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 4620 agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc 4680 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 4740 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 4800 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 4860 tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 4920 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 4980 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 5040 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 5100 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctt 5153 <210> 4 <211> 4442 <212> ДНК <213> Искусственная последовательность <220> <223> pGX9371 <400> 4 gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta 60 atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata 120 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 180 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 240 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 300 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 360 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 420 gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag 480 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 540 aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga 600 ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga 660 aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt 720 accgagctcg gatccgccac catggtgctg cagactcagg tgtttatttc actgctgctg 780 tggatttccg gcgcttacgg cgacattcag atgacccaga gcccctccac actgagcgcc 840 tccgtgggcg acagagtgac aatcacatgc aagtgtcagc tgtctgtggg ctatatgcac 900 tggtatcagc agaagcccgg caaggcccca aagctgctga tctatgacac ctctaagctg 960 gcctctggcg tgccaagcag attctccggc agcggctccg gcaccgagtt caccctgaca 1020 atctcctctc tgcagccaga cgatttcgcc acatactact gctttcaggg ctccggctac 1080 ccattcacat ttggcggcgg cacaaagctg gagatcaagg gcggcggcgg ctccggcggc 1140 ggcggctctg gcggcggcgg ctctcaggtg acactgcggg agtccggccc agccctggtg 1200 aagccaaccc agacactgac actgacctgt acattttccg gcttctctct gtccaccagc 1260 ggcatgagcg tgggctggat cagacagccc cctggcaagg ccctggagtg gctggccgat 1320 atctggtggg acgataagaa ggactacaat ccttccctga agtctagact gaccatctcc 1380 aaggatacct ccaagaatca ggtggtgctg aaggtgacca acatggaccc tgccgataca 1440 gccacctatt actgcgccag aagcatgatc accaactggt actttgacgt gtggggcgcc 1500 ggcacaaccg tgacagtgtc ttccgagcct agaggcccaa ccatcaagcc atgcccaccc 1560 tgtaagtgtc ccgccccaaa cctgctgggc ggcccatccg tgttcatctt tccccctaag 1620 atcaaggacg tgctgatgat cagcctgagc ccaatcgtga catgcgtggt ggtggacgtg 1680 tccgaggatg acccagatgt gcagatctct tggttcgtga ataacgtgga ggtgcacacc 1740 gcccagaccc agacccacag agaggattac aattccacac tgagagtggt gtccgccctg 1800 cctatccagc accaggattg gatgagcggc aaggagttta agtgcaaggt gaacaataag 1860 gacctgcccg ccccaatcga gagaaccatc tccaagccaa agggctctgt gagggcccca 1920 caggtgtacg tgctgcctcc tccagaggag gagatgacaa agaagcaggt gacactgacc 1980 tgcatggtga ccgacttcat gcccgaggac atctacgtgg agtggacaaa caatggcaag 2040 acagagctga actataagaa caccgagcca gtgctggatt ccgacggctc ttacttcatg 2100 tactccaagc tgagagtgga gaagaagaac tgggtggagc ggaatagcta ctcctgttcc 2160 gtggtccacg aagggctgca taaccaccac accactaagt cattttcaag aaccccaggc 2220 aaatgataac tcgagtctag agggcccgtt taaacccgct gatcagcctc gactgtgcct 2280 tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt 2340 gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg 2400 tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac 2460 aatagcaggc atgctgggga tgcggtgggc tctatggctt ctactgggcg gttttatgga 2520 cagcaagcga accggaattg ccagctgggg cgccctctgg taaggttggg aagccctgca 2580 aagtaaactg gatggctttc ttgccgccaa ggatctgatg gcgcagggga tcaagctctg 2640 atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt 2700 ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct 2760 gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga 2820 ccgacctgtc cggtgccctg aatgaactgc aagacgaggc agcgcggcta tcgtggctgg 2880 ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact 2940 ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg 3000 agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct 3060 gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg 3120 gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt 3180 tcgccaggct caaggcgagc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg 3240 cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc 3300 ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag 3360 agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt 3420 cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgaattatt aacgcttaca 3480 atttcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatcaggt 3540 ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca 3600 aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata gcacgtgcta 3660 aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc 3720 aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 3780 ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 3840 ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 3900 actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc 3960 caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 4020 gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 4080 ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 4140 cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 4200 cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 4260 acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 4320 ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 4380 gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 4440 tt 4442 <210> 5 <211> 5174 <212> ДНК <213> Искусственная последовательность <220> <223> pGX9383 <400> 5 gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta 60 atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata 120 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 180 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 240 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 300 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 360 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 420 gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag 480 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 540 aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga 600 ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga 660 aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt 720 accgagctcg gatccgccac catggactgg acttggagaa tcctgttcct ggtcgccgcc 780 gcaactggga ctcatgctca ggtgcagctg gtgcagagcg gggcagaggt gaagaagcca 840 ggcagctccg tgaaggtgtc ttgcaaggca agcggcggct ctctgagcac ctacggcatc 900 cactgggtga ggcaggcacc aggacagggc ctggagtggg tgggcggcgt gatgaccgtg 960 tacggcaaga ccacatatgg ccagaacttc cagggcaggg tgacaatcgc cgtggaccgc 1020 tctaccaata cagcctacat ggagctgtct agcctgacca gcgacgatac cggcacatac 1080 tattgcgcca ccgactctta ctacgtgtgg acaggcagct atccccctcc attcgatctg 1140 tggggccagg gcaccctggt gacagtgtcc tctgcctcta caaagggacc aagcgtgttt 1200 ccactggcac ctagctccaa gtccacctct ggcggcacag ccgccctggg ctgtctggtg 1260 aaggattact tccctgagcc agtgaccgtg tcctggaact ctggcgccct gaccagcgga 1320 gtgcacacat ttcccgccgt gctgcagtct agcggcctgt actccctgtc ctctgtggtg 1380 accgtgccta gctcctctct gggcacccag acatatatct gcaacgtgaa tcacaagcct 1440 agcaatacaa aggtggacaa gaaggtggag ccaaagtcct gtgataagac ccacacatgc 1500 cctccctgtc cagcacctga gctgctgggc ggcccaagcg tgttcctgtt tccacccaag 1560 cccaaggaca ccctgatgat ctccagaacc ccagaggtga catgcgtggt ggtggacgtg 1620 tctcacgagg accccgaggt gaagtttaac tggtacgtgg atggcgtgga ggtgcacaat 1680 gccaagacca agccccggga ggagcagtac aactccacct atagagtggt gtctgtgctg 1740 acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gagcaataag 1800 gccctgccag cccccatcga gaagaccatc tccaaggcaa agggacagcc aagggagcca 1860 caggtgtaca cactgcctcc atcccgcgac gagctgacca agaaccaggt gtctctgaca 1920 tgtctggtga agggcttcta tccctctgat atcgccgtgg agtgggagag caatggccag 1980 cctgagaaca attacaagac cacaccccct gtgctggaca gcgatggctc cttctttctg 2040 tattccaagc tgaccgtgga caagtctcgg tggcagcagg gcaacgtgtt tagctgctcc 2100 gtgatgcacg aggccctgca caatcactac acccagaagt ctctgagcct gtccccaggc 2160 aagaggggaa gaaagcggag atctggcagc ggcgccacaa acttcagcct gctgaagcag 2220 gccggcgatg tggaggagaa tcctggccca atggtgctgc agacccaggt gtttatcagc 2280 ctgctgctgt ggatctccgg agcatacgga gagatcgtgc tgacccagac accaggaacc 2340 cagtccctgt ctcctggaca gtccgccaca ctgtcttgta gagccagcca ctccgtgggc 2400 aatgactacc tggcctggta tcagcagaag cctggacaga gcccacggct gctgatccac 2460 ggagcataca ggagggactc cggcatccct gatagattca tcggctctgg cagcggcacc 2520 gactttaccc tgacaatcga tagcctggag cctgacgatt gcgccgtgta ctattgtcag 2580 cagtatggct cctggccact gaccttcggc ggcggcacaa aggtggacat caagaggacc 2640 gtggccgccc ctagcgtgtt catctttcca ccctccgatg agcagctgaa gagcggcaca 2700 gcctccgtgg tgtgcctgct gaacaacttc tacccacgcg aggccaaggt gcagtggaag 2760 gtggacaacg ccctgcagtc tggcaatagc caggagtccg tgaccgagca ggactctaag 2820 gatagcacat attccctgag ctccaccctg acactgtcca aggccgatta cgagaagcac 2880 aaggtgtatg cctgtgaggt cacccaccag ggactgtctt cacccgtcac aaaatccttc 2940 aataggggag aatgctgata actcgagtct agagggcccg tttaaacccg ctgatcagcc 3000 tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg 3060 accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat 3120 tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag 3180 gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctactggg 3240 cggttttatg gacagcaagc gaaccggaat tgccagctgg ggcgccctct ggtaaggttg 3300 ggaagccctg caaagtaaac tggatggctt tcttgccgcc aaggatctga tggcgcaggg 3360 gatcaagctc tgatcaagag acaggatgag gatcgtttcg catgattgaa caagatggat 3420 tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac 3480 agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc 3540 tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag gcagcgcggc 3600 tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag 3660 cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc 3720 ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg 3780 atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc 3840 ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc 3900 cagccgaact gttcgccagg ctcaaggcga gcatgcccga cggcgaggat ctcgtcgtga 3960 cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca 4020 tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg 4080 atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg 4140 ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgaatta 4200 ttaacgctta caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac 4260 accgcatcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc 4320 taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa 4380 tagcacgtgc taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat 4440 aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta 4500 gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa 4560 acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt 4620 tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag 4680 ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta 4740 atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca 4800 agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag 4860 cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa 4920 agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga 4980 acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc 5040 gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc 5100 ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt 5160 gctcacatgt tctt 5174 <210> 6 <211> 1478 <212> ДНК <213> Искусственная последовательность <220> <223> Последовательность pGX9369 кодирующая нуклеотид <400> 6 ggtgctgcag acccaggtgt ttatttcact gctgctgtgg atttcaggag cctacgggga 60 cattcagatg acccagagcc cttcaacact gtccgccagc gtgggcgaca gagtgacaat 120 cacctgtaag tgccagctga gcgtgggcta tatgcactgg tatcagcaga agcctggcaa 180 ggccccaaag ctgctgatct atgacaccag caagctggcc tctggcgtgc catccagatt 240 ctccggctct ggcagcggca ccgagtttac actgaccatc tccagcctgc agccagatga 300 cttcgccacc tactattgct tccagggcag cggctatccc ttcacctttg gcggcggcac 360 aaagctggag atcaagggcg gcggcggctc cggcggcggc ggctctggcg gcggcggctc 420 tcaggtgacc ctgagagagt ccggcccagc cctggtgaag ccaacccaga ccctgacact 480 gacatgcacc ttctccggct tcagcctgtc caccagcggc atgtccgtgg gctggatcag 540 gcagccccca ggcaaggccc tggagtggct ggccgatatc tggtgggacg ataagaagga 600 ctacaacccc tccctgaaga gcagactgac catcagcaag gataccagca agaaccaggt 660 ggtgctgaag gtgacaaata tggacccagc cgataccgcc acatactact gtgccagatc 720 catgatcaca aattggtact tcgacgtgtg gggcgccggc acaaccgtga cagtgagctc 780 tgagccaaag tcctgcgaca agacccacac ctgtcctcct tgtccagccc ccgagctgct 840 gggcggccca agcgtgttcc tgtttccccc taagccaaag gataccctga tgatctccag 900 aaccccagag gtgacatgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt 960 caattggtac gtggatggcg tggaggtgca caatgccaag accaagccaa gagaggagca 1020 gtataactct acatatcgcg tggtgtccgt gctgacagtg ctgcaccagg actggctgaa 1080 tggcaaggag tacaagtgca aggtgtccaa taaggccctg ccagccccta tcgagaagac 1140 aatctccaag gccaagggcc agcccagaga gccacaggtg tatacactgc caccctccag 1200 agatgagctg acaaagaatc aggtgtccct gacatgtctg gtgaagggct tttatccctc 1260 cgatatcgcc gtggagtggg agtctaatgg ccagcccgag aataactata agacaacccc 1320 tccagtgctg gactccgatg gctccttttt cctgtattcc aagctgaccg tggataagag 1380 caggtggcag cagggcaacg tgttctcttg ttccgtgatg cacgaagcac tgcacaacca 1440 ctacacccag aagtcactgt cactgtcacc aggaaaat 1478 <210> 7 <211> 493 <212> БЕЛОК <213> Искусственная последовательность <220> <223> Аминокислотная последовательность pGX9369 <400> 7 Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 1. 5 10 15 Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 20 25 30 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser 35 40 45 Val Gly Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly 100 105 110 Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr 130 135 140 Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr 145 150 155 160 Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Ser 165 170 175 Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 180 185 190 Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 195 200 205 Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Lys 210 215 220 Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 225 230 235 240 Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 245 250 255 Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490