ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> MedImmune LLC <120> КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ АТОПИЧЕСКОГО ДЕРМАТИТА И ВЫБОРА ЛЕЧЕНИЯ <130> ATOP-101P1 <160> 12 <170> PatentIn версия 3.5 <210> 1 <211> 743 <212> ДНК <213> Homo sapiens <220> <221> другой_признак <223> TSLP <220> <221> CDS <222> (200)..(676) <400> 1 gcagccagaa agctctggag catcagggag actccaactt aaggcaacag catgggtgaa 60 taagggcttc ctgtggactg gcaatgagag gcaaaacctg gtgcttgagc actggcccct 120 aaggcaggcc ttacagatct cttacactcg tggtgggaag agtttagtgt gaaactgggg 180 tggaattggg tgtccacgt atg ttc cct ttt gcc tta cta tat gtt ctg tca 232 Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser 1 5 10 gtt tct ttc agg aaa atc ttc atc tta caa ctt gta ggg ctg gtg tta 280 Val Ser Phe Arg Lys Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu 15 20 25 act tac gac ttc act aac tgt gac ttt gag aag att aaa gca gcc tat 328 Thr Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr 30 35 40 ctc agt act att tct aaa gac ctg att aca tat atg agt ggg acc aaa 376 Leu Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys 45 50 55 agt acc gag ttc aac aac acc gtc tct tgt agc aat cgg cca cat tgc 424 Ser Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys 60 65 70 75 ctt act gaa atc cag agc cta acc ttc aat ccc acc gcc ggc tgc gcg 472 Leu Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala 80 85 90 tcg ctc gcc aaa gaa atg ttc gcc atg aaa act aag gct gcc tta gct 520 Ser Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala 95 100 105 atc tgg tgc cca ggc tat tcg gaa act cag ata aat gct act cag gca 568 Ile Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala 110 115 120 atg aag aag agg aga aaa agg aaa gtc aca acc aat aaa tgt ctg gaa 616 Met Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu 125 130 135 caa gtg tca caa tta caa gga ttg tgg cgt cgc ttc aat cga cct tta 664 Gln Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu 140 145 150 155 ctg aaa caa cag taaaccatct ttattatggt catatttcac agcccaaaat 716 Leu Lys Gln Gln aaatcatctt tattaagtaa aaaaaaa 743 <210> 2 <211> 159 <212> БЕЛОК <213> Homo sapiens <400> 2 Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser Val Ser Phe Arg Lys 1 5 10 15 Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu Thr Tyr Asp Phe Thr 20 25 30 Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu Ser Thr Ile Ser 35 40 45 Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser Thr Glu Phe Asn 50 55 60 Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu Thr Glu Ile Gln 65 70 75 80 Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser Leu Ala Lys Glu 85 90 95 Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile Trp Cys Pro Gly 100 105 110 Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met Lys Lys Arg Arg 115 120 125 Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln Val Ser Gln Leu 130 135 140 Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu Lys Gln Gln 145 150 155 <210> 3 <211> 11 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> LCDR1 <400> 3 Gly Gly Asn Asn Leu Gly Ser Lys Ser Val His 1 5 10 <210> 4 <211> 7 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> LCDR2 <400> 4 Asp Asp Ser Asp Arg Pro Ser 1 5 <210> 5 <211> 11 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> LCDR3 <400> 5 Gln Val Trp Asp Ser Ser Ser Asp His Val Val 1 5 10 <210> 6 <211> 5 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> HCDR1 <400> 6 Thr Tyr Gly Met His 1 5 <210> 7 <211> 17 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> HCDR2 <400> 7 Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 8 <211> 13 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> HCDR3 <400> 8 Ala Pro Gln Trp Glu Leu Val His Glu Ala Phe Asp Ile 1 5 10 <210> 9 <211> 366 <212> ДНК <213> Homo sapiens <220> <221> другой_признак <223> VH тяжелой цепи <400> 9 cagatgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcaga acctatggca tgcactgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggcagtt atatggtatg atggaagtaa taaacactat 180 gcagactccg tgaagggccg attcaccatc accagagaca attccaagaa cactctgaat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagcccct 300 cagtgggagc tagttcatga agcttttgat atctggggcc aagggacaat ggtcaccgtc 360 tcttca 366 <210> 10 <211> 122 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> VH тяжелой цепи <400> 10 Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ser Lys Asn Thr Leu Asn 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Pro Gln Trp Glu Leu Val His Glu Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 11 <211> 325 <212> ДНК <213> Homo sapiens <220> <221> другой_признак <223> VL легкой цепи <400> 11 tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt 60 acctgtgggg gaaacaacct tggaagtaaa agtgtgcact ggtaccagca gaagccaggc 120 caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcatggat ccctgagcga 180 ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggg cgaagccggg 240 gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtatttcgg 300 cggagggacc aagctgaccg tccta 325 <210> 12 <211> 108 <212> БЕЛОК <213> Homo sapiens <220> <221> MISC_FEATURE <223> VL легкой цепи <400> 12 Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Asp Asp Ser Asp Arg Pro Ser Trp Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Gly Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105