ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> Immune Design Corp. Dubensky, et al. <120> Вакцины против ВПГ-2 <130> 31943/47733 <150> 61/647,764 <151> 2012-05-16 <150> 61/679,387 <151> 2012-08-03 <150> 61/714,158 <151> 2012-10-15 <160> 17 <170> PatentIn версия 3.5 <210> 1 <211> 904 <212> Белок <213> Вирус простого герпеса 2 <400> 1 Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 1 5 10 15 Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 20 25 30 Ser Gly Gly Val Ala Ala Thr Val Ala Ala Asn Gly Gly Pro Ala Ser 35 40 45 Arg Pro Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg 50 55 60 Lys Thr Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp 65 70 75 80 Ala Asn Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu 85 90 95 Arg Glu Ile Lys Val Glu Asn Ala Asp Ala Gln Phe Tyr Val Cys Pro 100 105 110 Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys 115 120 125 Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val 130 135 140 Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr 145 150 155 160 Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln 165 170 175 Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val 180 185 190 Ile Asp Lys Ile Asn Thr Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr 195 200 205 Val Arg Asn Asn Met Glu Thr Thr Ala Phe His Arg Asp Asp His Glu 210 215 220 Thr Asp Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg 225 230 235 240 Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala 245 250 255 Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp 260 265 270 Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp 275 280 285 Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr 290 295 300 Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe 305 310 315 320 Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr 325 330 335 Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val 340 345 350 Pro Lys Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp 355 360 365 Glu Met Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp 370 375 380 Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr Glu Tyr Ser Leu Ser 385 390 395 400 Arg Val Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile 405 410 415 Asp Arg Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly 420 425 430 Gln Pro Gln Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gln 435 440 445 Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met 450 455 460 Arg Glu Gln Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg 465 470 475 480 Glu Ala Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser 485 490 495 Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg 500 505 510 His Val Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu 515 520 525 Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro 530 535 540 Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met 545 550 555 560 Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp 565 570 575 Asn Val Ile Val Gln Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr 580 585 590 Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gln Gly Pro 595 600 605 Leu Ile Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg 610 615 620 Asp Ala Leu Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe 625 630 635 640 Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gln Leu 645 650 655 Ser Arg Ala Asp Val Thr Thr Val Ser Thr Phe Ile Asp Leu Asn Ile 660 665 670 Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg 675 680 685 His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gln Arg 690 695 700 Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile 705 710 715 720 Arg Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe 725 730 735 Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly 740 745 750 Val Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met 755 760 765 Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 770 775 780 Leu Val Ala Ala Phe Phe Ala Phe Arg Tyr Val Leu Gln Leu Gln Arg 785 790 795 800 Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr 805 810 815 Ser Asp Pro Gly Gly Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly 820 825 830 Gly Gly Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 835 840 845 Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg 850 855 860 Lys Lys Gly Thr Ser Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val 865 870 875 880 Leu Arg Lys Arg Asn Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp 885 890 895 Glu Ala Gly Asp Glu Asp Glu Leu 900 <210> 2 <211> 393 <212> Белок <213> Вирус простого герпеса 2 <400> 2 Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 1 5 10 15 Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 20 25 30 Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 35 40 45 Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 50 55 60 Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 65 70 75 80 Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 85 90 95 His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 100 105 110 Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 115 120 125 Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 130 135 140 Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 145 150 155 160 Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 165 170 175 Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 180 185 190 Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 195 200 205 Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 210 215 220 Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 225 230 235 240 Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 245 250 255 Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 260 265 270 Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 275 280 285 Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 290 295 300 Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 305 310 315 320 Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 325 330 335 Ser Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 340 345 350 Val Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gln 355 360 365 Met Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 370 375 380 Pro Pro Ser His Gln Pro Leu Phe Tyr 385 390 <210> 3 <211> 306 <212> Белок <213> Вирус простого герпеса 2 <400> 3 Lys Tyr Ala Leu Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg 1 5 10 15 Phe Arg Gly Lys Asn Leu Pro Val Leu Asp Gln Leu Thr Asp Pro Pro 20 25 30 Gly Val Lys Arg Val Tyr His Ile Gln Pro Ser Leu Glu Asp Pro Phe 35 40 45 Gln Pro Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 50 55 60 Ala Cys Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gln Ile 65 70 75 80 Val Arg Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr 85 90 95 Ile Ala Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val 100 105 110 Met Glu Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro 115 120 125 Ile Arg Thr Gln Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val 130 135 140 Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 145 150 155 160 Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 165 170 175 Thr Gln Phe Ile Leu Glu His Arg Ala Arg Ala Ser Cys Lys Tyr Ala 180 185 190 Leu Pro Leu Arg Ile Pro Pro Ala Ala Cys Leu Thr Ser Lys Ala Tyr 195 200 205 Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 210 215 220 Pro Glu Asn Gln Arg Thr Val Ala Leu Tyr Ser Leu Lys Ile Ala Gly 225 230 235 240 Trp His Gly Pro Lys Pro Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 245 250 255 Leu Ser Asp Thr Thr Asn Ala Thr Gln Pro Glu Leu Val Pro Glu Asp 260 265 270 Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Ala Gly Thr Val Ser Ser 275 280 285 Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Val Ala Pro 290 295 300 His His 305 <210> 4 <211> 1374 <212> Белок <213> Вирус простого герпеса 2 <400> 4 Met Ala Ala Pro Ala Arg Asp Pro Pro Gly Tyr Arg Tyr Ala Ala Ala 1 5 10 15 Met Val Pro Thr Gly Ser Ile Leu Ser Thr Ile Glu Val Ala Ser His 20 25 30 Arg Arg Leu Phe Asp Phe Phe Ala Arg Val Arg Ser Asp Glu Asn Ser 35 40 45 Leu Tyr Asp Val Glu Phe Asp Ala Leu Leu Gly Ser Tyr Cys Asn Thr 50 55 60 Leu Ser Leu Val Arg Phe Leu Glu Leu Gly Leu Ser Val Ala Cys Val 65 70 75 80 Cys Thr Lys Phe Pro Glu Leu Ala Tyr Met Asn Glu Gly Arg Val Gln 85 90 95 Phe Glu Val His Gln Pro Leu Ile Ala Arg Asp Gly Pro His Pro Val 100 105 110 Glu Gln Pro Val His Asn Tyr Met Thr Lys Val Ile Asp Arg Arg Ala 115 120 125 Leu Asn Ala Ala Phe Ser Leu Ala Thr Glu Ala Ile Ala Leu Leu Thr 130 135 140 Gly Glu Ala Leu Asp Gly Thr Gly Ile Ser Leu His Arg Gln Leu Arg 145 150 155 160 Ala Ile Gln Gln Leu Ala Arg Asn Val Gln Ala Val Leu Gly Ala Phe 165 170 175 Glu Arg Gly Thr Ala Asp Gln Met Leu His Val Leu Leu Glu Lys Ala 180 185 190 Pro Pro Leu Ala Leu Leu Leu Pro Met Gln Arg Tyr Leu Asp Asn Gly 195 200 205 Arg Leu Ala Thr Arg Val Ala Arg Ala Thr Leu Val Ala Glu Leu Lys 210 215 220 Arg Ser Phe Cys Asp Thr Ser Phe Phe Leu Gly Lys Ala Gly His Arg 225 230 235 240 Arg Glu Ala Ile Glu Ala Trp Leu Val Asp Leu Thr Thr Ala Thr Gln 245 250 255 Pro Ser Val Ala Val Pro Arg Leu Thr His Ala Asp Thr Arg Gly Arg 260 265 270 Pro Val Asp Gly Val Leu Val Thr Thr Ala Ala Ile Lys Gln Arg Leu 275 280 285 Leu Gln Ser Phe Leu Lys Val Glu Asp Thr Glu Ala Asp Val Pro Val 290 295 300 Thr Tyr Gly Glu Met Val Leu Asn Gly Ala Asn Leu Val Thr Ala Leu 305 310 315 320 Val Met Gly Lys Ala Val Arg Ser Leu Asp Asp Val Gly Arg His Leu 325 330 335 Leu Glu Met Gln Glu Glu Gln Leu Glu Ala Asn Arg Glu Thr Leu Asp 340 345 350 Glu Leu Glu Ser Ala Pro Gln Thr Thr Arg Val Arg Ala Asp Leu Val 355 360 365 Ala Ile Gly Asp Arg Leu Val Phe Leu Glu Ala Leu Glu Lys Arg Ile 370 375 380 Tyr Ala Ala Thr Asn Val Pro Tyr Pro Leu Val Gly Ala Met Asp Leu 385 390 395 400 Thr Phe Val Leu Pro Leu Gly Leu Phe Asn Pro Ala Met Glu Arg Phe 405 410 415 Ala Ala His Ala Gly Asp Leu Val Pro Ala Pro Gly His Pro Glu Pro 420 425 430 Arg Ala Phe Pro Pro Arg Gln Leu Phe Phe Trp Gly Lys Asp His Gln 435 440 445 Val Leu Arg Leu Ser Met Glu Asn Ala Val Gly Thr Val Cys His Pro 450 455 460 Ser Leu Met Asn Ile Asp Ala Ala Val Gly Gly Val Asn His Asp Pro 465 470 475 480 Val Glu Ala Ala Asn Pro Tyr Gly Ala Tyr Val Ala Ala Pro Ala Gly 485 490 495 Pro Gly Ala Asp Met Gln Gln Arg Phe Leu Asn Ala Trp Arg Gln Arg 500 505 510 Leu Ala His Gly Arg Val Arg Trp Val Ala Glu Cys Gln Met Thr Ala 515 520 525 Glu Gln Phe Met Gln Pro Asp Asn Ala Asn Leu Ala Leu Glu Leu His 530 535 540 Pro Ala Phe Asp Phe Phe Ala Gly Val Ala Asp Val Glu Leu Pro Gly 545 550 555 560 Gly Glu Val Pro Pro Ala Gly Pro Gly Ala Ile Gln Ala Thr Trp Arg 565 570 575 Val Val Asn Gly Asn Leu Pro Leu Ala Leu Cys Pro Val Ala Phe Arg 580 585 590 Asp Ala Arg Gly Leu Glu Leu Gly Val Gly Arg His Ala Met Ala Pro 595 600 605 Ala Thr Ile Ala Ala Val Arg Gly Ala Phe Glu Asp Arg Ser Tyr Pro 610 615 620 Ala Val Phe Tyr Leu Leu Gln Ala Ala Ile His Gly Ser Glu His Val 625 630 635 640 Phe Cys Ala Leu Ala Arg Leu Val Thr Gln Cys Ile Thr Ser Tyr Trp 645 650 655 Asn Asn Thr Arg Cys Ala Ala Phe Val Asn Asp Tyr Ser Leu Val Ser 660 665 670 Tyr Ile Val Thr Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys Met Ala 675 680 685 Val Tyr Arg Asp Leu Val Ala His Val Glu Ala Leu Ala Gln Leu Val 690 695 700 Asp Asp Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly Gln Ala Gln Ala 705 710 715 720 Glu Leu Asn His Leu Met Arg Asp Pro Ala Leu Leu Pro Pro Leu Val 725 730 735 Trp Asp Cys Asp Gly Leu Met Arg His Ala Ala Leu Asp Arg His Arg 740 745 750 Asp Cys Arg Ile Asp Ala Gly Gly His Glu Pro Val Tyr Ala Ala Ala 755 760 765 Cys Asn Val Ala Thr Ala Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu 770 775 780 His Asn Thr Gln Ala Arg Ala Ala Asp Ala Ala Asp Asp Arg Pro His 785 790 795 800 Arg Pro Ala Asp Trp Thr Val His His Lys Ile Tyr Tyr Tyr Val Leu 805 810 815 Val Pro Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala Gly Val Arg Phe 820 825 830 Asp Arg Val Tyr Ala Thr Leu Gln Asn Met Val Val Pro Glu Ile Ala 835 840 845 Pro Gly Glu Glu Cys Pro Ser Asp Pro Val Thr Asp Pro Ala His Pro 850 855 860 Leu His Pro Ala Asn Leu Val Ala Asn Thr Val Asn Ala Met Phe His 865 870 875 880 Asn Gly Arg Val Val Val Asp Gly Pro Ala Met Leu Thr Leu Gln Val 885 890 895 Leu Ala His Asn Met Ala Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala 900 905 910 Ala Pro Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala Asn Met Arg Ile 915 920 925 Phe Asp Gly Ala Leu His Ala Gly Val Leu Leu Met Ala Pro Gln His 930 935 940 Leu Asp His Thr Ile Gln Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val 945 950 955 960 His Ala Leu Phe Ala Gly Ala Asp His Val Ala Asn Ala Pro Asn Phe 965 970 975 Pro Pro Ala Leu Arg Asp Leu Ala Arg His Val Pro Leu Val Pro Pro 980 985 990 Ala Leu Gly Ala Asn Tyr Phe Ser Ser Ile Arg Gln Pro Val Val Gln 995 1000 1005 His Ala Arg Glu Ser Ala Ala Gly Glu Asn Ala Leu Thr Tyr Ala 1010 1015 1020 Leu Met Ala Gly Tyr Phe Lys Met Ser Pro Val Ala Leu Tyr His 1025 1030 1035 Gln Leu Lys Thr Gly Leu His Pro Gly Phe Gly Phe Thr Val Val 1040 1045 1050 Arg Gln Asp Arg Phe Val Thr Glu Asn Val Leu Phe Ser Glu Arg 1055 1060 1065 Ala Ser Glu Ala Tyr Phe Leu Gly Gln Leu Gln Val Ala Arg His 1070 1075 1080 Glu Thr Gly Gly Gly Val Ser Phe Thr Leu Thr Gln Pro Arg Gly 1085 1090 1095 Asn Val Asp Leu Gly Val Gly Tyr Thr Ala Val Ala Ala Thr Ala 1100 1105 1110 Thr Val Arg Asn Pro Val Thr Asp Met Gly Asn Leu Pro Gln Asn 1115 1120 1125 Phe Tyr Leu Gly Arg Gly Ala Pro Pro Leu Leu Asp Asn Ala Ala 1130 1135 1140 Ala Val Tyr Leu Arg Asn Ala Val Val Ala Gly Asn Arg Leu Gly 1145 1150 1155 Pro Ala Gln Pro Leu Pro Val Phe Gly Cys Ala Gln Val Pro Arg 1160 1165 1170 Arg Ala Gly Met Asp His Gly Gln Asp Ala Val Cys Glu Phe Ile 1175 1180 1185 Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe Arg Arg Pro Cys 1190 1195 1200 Asn Pro Arg Gly Arg Ala Ala Gly Gly Val Tyr Ala Gly Asp Lys 1205 1210 1215 Glu Gly Asp Val Ile Ala Leu Met Tyr Asp His Gly Gln Ser Asp 1220 1225 1230 Pro Ala Arg Pro Phe Ala Ala Thr Ala Asn Pro Trp Ala Ser Gln 1235 1240 1245 Arg Phe Ser Tyr Gly Asp Leu Leu Tyr Asn Gly Ala Tyr His Leu 1250 1255 1260 Asn Gly Ala Ser Pro Val Leu Ser Pro Cys Phe Lys Phe Phe Thr 1265 1270 1275 Ala Ala Asp Ile Thr Ala Lys His Arg Cys Leu Glu Arg Leu Ile 1280 1285 1290 Val Glu Thr Gly Ser Ala Val Ser Thr Ala Thr Ala Ala Ser Asp 1295 1300 1305 Val Gln Phe Lys Arg Pro Pro Gly Cys Arg Glu Leu Val Glu Asp 1310 1315 1320 Pro Cys Gly Leu Phe Gln Glu Ala Tyr Pro Ile Thr Cys Ala Ser 1325 1330 1335 Asp Pro Ala Leu Leu Arg Ser Ala Arg Asp Gly Glu Ala His Ala 1340 1345 1350 Arg Glu Thr His Phe Thr Gln Tyr Leu Ile Tyr Asp Ala Ser Pro 1355 1360 1365 Leu Lys Gly Leu Ser Leu 1370 <210> 5 <211> 585 <212> Белок <213> Вирус простого герпеса 2 <400> 5 Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His Arg 1 5 10 15 Arg Phe Ile Val Ala Asp Ser Arg Ser Phe Ile Thr Pro Glu Phe Pro 20 25 30 Arg Asp Phe Trp Met Leu Pro Val Phe Asn Ile Pro Arg Glu Thr Ala 35 40 45 Ala Glu Arg Ala Ala Val Leu Gln Ala Gln Arg Thr Ala Ala Ala Ala 50 55 60 Ala Leu Glu Asn Ala Ala Leu Gln Ala Ala Glu Leu Pro Val Asp Ile 65 70 75 80 Glu Arg Arg Ile Arg Pro Ile Glu Gln Gln Val His His Ile Ala Asp 85 90 95 Ala Leu Glu Ala Leu Glu Thr Ala Ala Ala Ala Ala Glu Glu Ala Asp 100 105 110 Ala Ala Arg Asp Ala Glu Ala Arg Gly Glu Gly Ala Ala Asp Gly Ala 115 120 125 Ala Pro Ser Pro Thr Ala Gly Pro Ala Ala Ala Glu Met Glu Val Gln 130 135 140 Ile Val Arg Asn Asp Pro Pro Leu Arg Tyr Asp Thr Asn Leu Pro Val 145 150 155 160 Asp Leu Leu His Met Val Tyr Ala Gly Arg Gly Ala Ala Gly Ser Ser 165 170 175 Gly Val Val Phe Gly Thr Trp Tyr Arg Thr Ile Gln Glu Arg Thr Ile 180 185 190 Ala Asp Phe Pro Leu Thr Thr Arg Ser Ala Asp Phe Arg Asp Gly Arg 195 200 205 Met Ser Lys Thr Phe Met Thr Ala Leu Val Leu Ser Leu Gln Ser Cys 210 215 220 Gly Arg Leu Tyr Val Gly Gln Arg His Tyr Ser Ala Phe Glu Cys Ala 225 230 235 240 Val Leu Cys Leu Tyr Leu Leu Tyr Arg Thr Thr His Glu Ser Ser Pro 245 250 255 Asp Arg Asp Arg Ala Pro Val Ala Phe Gly Asp Leu Leu Ala Arg Leu 260 265 270 Pro Arg Tyr Leu Ala Arg Leu Ala Ala Val Ile Gly Asp Glu Ser Gly 275 280 285 Arg Pro Gln Tyr Arg Tyr Arg Asp Asp Lys Leu Pro Lys Ala Gln Phe 290 295 300 Ala Ala Ala Gly Gly Arg Tyr Glu His Gly Ala Leu Ala Thr His Val 305 310 315 320 Val Ile Ala Thr Leu Val Arg His Gly Val Leu Pro Ala Ala Pro Gly 325 330 335 Asp Val Pro Arg Asp Thr Ser Thr Arg Val Asn Pro Asp Asp Val Ala 340 345 350 His Arg Asp Asp Val Asn Arg Ala Ala Ala Ala Phe Leu Ala Arg Gly 355 360 365 His Asn Leu Phe Leu Trp Glu Asp Gln Thr Leu Leu Arg Ala Thr Ala 370 375 380 Asn Thr Ile Thr Ala Leu Ala Val Leu Arg Arg Leu Leu Ala Asn Gly 385 390 395 400 Asn Val Tyr Ala Asp Arg Leu Asp Asn Arg Leu Gln Leu Gly Met Leu 405 410 415 Ile Pro Gly Ala Val Pro Ala Glu Ala Ile Ala Arg Gly Ala Ser Gly 420 425 430 Leu Asp Ser Gly Ala Ile Lys Ser Gly Asp Asn Asn Leu Glu Ala Leu 435 440 445 Cys Val Asn Tyr Val Leu Pro Leu Tyr Gln Ala Asp Pro Thr Val Glu 450 455 460 Leu Thr Gln Leu Phe Pro Gly Leu Ala Ala Leu Cys Leu Asp Ala Gln 465 470 475 480 Ala Gly Arg Pro Leu Ala Ser Thr Arg Arg Val Val Asp Met Ser Ser 485 490 495 Gly Ala Arg Gln Ala Ala Leu Val Arg Leu Thr Ala Leu Glu Leu Ile 500 505 510 Asn Arg Thr Arg Thr Asn Thr Thr Pro Val Gly Glu Ile Ile Asn Ala 515 520 525 His Asp Ala Leu Gly Ile Gln Tyr Glu Gln Gly Leu Gly Leu Leu Ala 530 535 540 Gln Gln Ala Arg Ile Gly Leu Ala Ser Asn Ala Lys Arg Phe Ala Thr 545 550 555 560 Phe Asn Val Gly Ser Asp Tyr Asp Leu Leu Tyr Phe Leu Cys Leu Gly 565 570 575 Phe Ile Pro Gln Tyr Leu Ser Val Ala 580 585 <210> 6 <211> 696 <212> Белок <213> Вирус простого герпеса 2 <400> 6 Met Ser Val Arg Gly His Ala Val Arg Arg Arg Arg Ala Ser Thr Arg 1 5 10 15 Ser His Ala Pro Ser Ala His Arg Ala Asp Ser Pro Val Glu Asp Glu 20 25 30 Pro Glu Gly Gly Gly Gly Gly Leu Met Gly Tyr Leu Arg Ala Val Phe 35 40 45 Asn Val Asp Asp Asp Ser Glu Val Glu Ala Ala Gly Glu Met Ala Ser 50 55 60 Glu Glu Pro Pro Pro Arg Arg Arg Arg Glu Ala Arg Gly His Pro Gly 65 70 75 80 Ser Arg Arg Ala Ser Glu Ala Arg Ala Ala Ala Pro Pro Arg Arg Ala 85 90 95 Ser Phe Pro Arg Pro Arg Ser Val Thr Ala Arg Ser Gln Ser Val Arg 100 105 110 Gly Arg Arg Asp Ser Ala Ile Thr Arg Ala Pro Arg Gly Gly Tyr Leu 115 120 125 Gly Pro Met Asp Pro Arg Asp Val Leu Gly Arg Val Gly Gly Ser Arg 130 135 140 Val Val Pro Ser Pro Leu Phe Leu Asp Glu Leu Ser Tyr Glu Glu Asp 145 150 155 160 Asp Tyr Pro Ala Ala Val Ala His Asp Asp Gly Ala Gly Ala Arg Pro 165 170 175 Pro Ala Thr Val Glu Ile Leu Ala Gly Arg Val Ser Gly Pro Glu Leu 180 185 190 Gln Ala Ala Phe Pro Leu Asp Arg Leu Thr Pro Arg Val Ala Ala Trp 195 200 205 Asp Glu Ser Val Arg Ser Ala Leu Ala Leu Gly His Pro Ala Gly Phe 210 215 220 Tyr Pro Cys Pro Asp Ser Ala Phe Gly Leu Ser Arg Val Gly Val Met 225 230 235 240 His Phe Ala Ser Pro Ala Asp Pro Lys Val Phe Phe Arg Gln Thr Leu 245 250 255 Gln Gln Gly Glu Ala Leu Ala Trp Tyr Val Thr Gly Asp Ala Ile Leu 260 265 270 Asp Leu Thr Asp Arg Arg Ala Lys Thr Ser Pro Ser Arg Ala Met Gly 275 280 285 Phe Leu Val Asp Ala Ile Val Arg Val Ala Ile Asn Gly Trp Val Cys 290 295 300 Gly Thr Arg Leu His Thr Glu Gly Arg Gly Ser Glu Leu Asp Asp Arg 305 310 315 320 Ala Ala Glu Leu Arg Arg Gln Phe Ala Ser Leu Thr Ala Leu Arg Pro 325 330 335 Val Gly Ala Ala Ala Val Pro Leu Leu Ser Ala Gly Gly Ala Ala Pro 340 345 350 Pro His Pro Gly Pro Asp Ala Ala Val Phe Arg Ser Ser Leu Gly Ser 355 360 365 Leu Leu Tyr Trp Pro Gly Val Arg Ala Leu Leu Gly Arg Asp Cys Arg 370 375 380 Val Ala Ala Arg Tyr Ala Gly Arg Met Thr Tyr Ile Ala Thr Gly Ala 385 390 395 400 Leu Leu Ala Arg Phe Asn Pro Gly Ala Val Lys Cys Val Leu Pro Arg 405 410 415 Glu Ala Ala Phe Ala Gly Arg Val Leu Asp Val Leu Ala Val Leu Ala 420 425 430 Glu Gln Thr Val Gln Trp Leu Ser Val Val Val Gly Ala Arg Leu His 435 440 445 Pro His Ser Ala His Pro Ala Phe Ala Asp Val Glu Gln Glu Ala Leu 450 455 460 Phe Arg Ala Leu Pro Leu Gly Ser Pro Gly Val Val Ala Ala Glu His 465 470 475 480 Glu Ala Leu Gly Asp Thr Ala Ala Arg Arg Leu Leu Ala Thr Ser Gly 485 490 495 Leu Asn Ala Val Leu Gly Ala Ala Val Tyr Ala Leu His Thr Ala Leu 500 505 510 Ala Thr Val Thr Leu Lys Tyr Ala Leu Ala Cys Gly Asp Ala Arg Arg 515 520 525 Arg Arg Asp Asp Ala Ala Ala Ala Arg Ala Val Leu Ala Thr Gly Leu 530 535 540 Ile Leu Gln Arg Leu Leu Gly Leu Ala Asp Thr Val Val Ala Cys Val 545 550 555 560 Ala Leu Ala Ala Phe Asp Gly Gly Ser Thr Ala Pro Glu Val Gly Thr 565 570 575 Tyr Thr Pro Leu Arg Tyr Ala Cys Val Leu Arg Ala Thr Gln Pro Leu 580 585 590 Tyr Ala Arg Thr Thr Pro Ala Lys Phe Trp Ala Asp Val Arg Ala Ala 595 600 605 Ala Glu His Val Asp Leu Arg Pro Ala Ser Ser Ala Pro Arg Ala Pro 610 615 620 Val Ser Gly Thr Ala Asp Pro Ala Phe Leu Leu Glu Asp Leu Ala Ala 625 630 635 640 Phe Pro Pro Ala Pro Leu Asn Ser Glu Ser Val Leu Gly Pro Arg Val 645 650 655 Arg Val Val Asp Ile Met Ala Gln Phe Arg Lys Leu Leu Met Gly Asp 660 665 670 Glu Glu Thr Ala Ala Leu Arg Ala His Val Ser Gly Arg Arg Ala Thr 675 680 685 Gly Leu Gly Gly Pro Pro Arg Pro 690 695 <210> 7 <211> 15 <212> Белок <213> Вирус простого герпеса 2 <400> 7 Gln Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu 1 5 10 15 <210> 8 <211> 15 <212> Белок <213> Вирус простого герпеса 2 <400> 8 Ser Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Val 1 5 10 15 <210> 9 <211> 15 <212> Белок <213> Вирус простого герпеса 2 <400> 9 Asn Tyr Phe Ser Ser Ile Arg Gln Pro Val Val Gln His Ala Arg 1 5 10 15 <210> 10 <211> 15 <212> Белок <213> Вирус простого герпеса 2 <400> 10 Cys Glu Phe Ile Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe 1 5 10 15 <210> 11 <211> 15 <212> Белок <213> Вирус простого герпеса 2 <400> 11 Met Asp Pro Tyr Tyr Pro Phe Asp Ala Leu Asp Val Trp Glu His 1 5 10 15 <210> 12 <211> 604 <212> Белок <213> Вирус простого герпеса 2 <400> 12 Arg Leu Ser Met Glu Asn Ala Val Gly Thr Val Cys His Pro Ser Leu 1 5 10 15 Met Asn Ile Asp Ala Ala Val Gly Gly Val Asn His Asp Pro Val Glu 20 25 30 Ala Ala Asn Pro Tyr Gly Ala Tyr Val Ala Ala Pro Ala Gly Pro Gly 35 40 45 Ala Asp Met Gln Gln Arg Phe Leu Asn Ala Trp Arg Gln Arg Leu Ala 50 55 60 His Gly Arg Val Arg Trp Val Ala Glu Cys Gln Met Thr Ala Glu Gln 65 70 75 80 Phe Met Gln Pro Asp Asn Ala Asn Leu Ala Leu Glu Leu His Pro Ala 85 90 95 Phe Asp Phe Phe Ala Gly Val Ala Asp Val Glu Leu Pro Gly Gly Glu 100 105 110 Val Pro Pro Ala Gly Pro Gly Ala Ile Gln Ala Thr Trp Arg Val Val 115 120 125 Asn Gly Asn Leu Pro Leu Ala Leu Cys Pro Val Ala Phe Arg Asp Ala 130 135 140 Arg Gly Leu Glu Leu Gly Val Gly Arg His Ala Met Ala Pro Ala Thr 145 150 155 160 Ile Ala Ala Val Arg Gly Ala Phe Glu Asp Arg Ser Tyr Pro Ala Val 165 170 175 Phe Tyr Leu Leu Gln Ala Ala Ile His Gly Asn Glu His Val Phe Cys 180 185 190 Ala Leu Ala Arg Leu Val Thr Gln Cys Ile Thr Ser Tyr Trp Asn Asn 195 200 205 Thr Arg Cys Ala Ala Phe Val Asn Asp Tyr Ser Leu Val Ser Tyr Ile 210 215 220 Val Thr Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys Met Ala Val Tyr 225 230 235 240 Arg Asp Leu Val Ala His Val Glu Ala Leu Ala Gln Leu Val Asp Asp 245 250 255 Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly Gln Ala Gln Ala Glu Leu 260 265 270 Asn His Leu Met Arg Asp Pro Ala Leu Leu Pro Pro Leu Val Trp Asp 275 280 285 Cys Asp Gly Leu Met Arg His Ala Ala Leu Asp Arg His Arg Asp Cys 290 295 300 Arg Ile Asp Ala Gly Gly His Glu Pro Val Tyr Ala Ala Ala Cys Asn 305 310 315 320 Val Ala Thr Ala Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu His Asn 325 330 335 Thr Gln Ala Arg Ala Ala Asp Ala Ala Asp Asp Arg Pro His Arg Pro 340 345 350 Ala Asp Trp Thr Val His His Lys Ile Tyr Tyr Tyr Val Leu Val Pro 355 360 365 Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala Gly Val Arg Phe Asp Arg 370 375 380 Val Tyr Ala Thr Leu Gln Asn Met Val Val Pro Glu Ile Ala Pro Gly 385 390 395 400 Glu Glu Cys Pro Ser Asp Pro Val Thr Asp Pro Ala His Pro Leu His 405 410 415 Pro Ala Asn Leu Val Ala Asn Thr Val Lys Arg Met Phe His Asn Gly 420 425 430 Arg Val Val Val Asp Gly Pro Ala Met Leu Thr Leu Gln Val Leu Ala 435 440 445 His Asn Met Ala Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala Ala Pro 450 455 460 Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala Asn Met Arg Ile Phe Asp 465 470 475 480 Gly Ala Leu His Ala Gly Val Leu Leu Met Ala Pro Gln His Leu Asp 485 490 495 His Thr Ile Gln Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val His Ala 500 505 510 Leu Phe Ala Gly Ala Asp His Val Ala Asn Ala Pro Asn Phe Pro Pro 515 520 525 Ala Leu Arg Asp Leu Ala Arg Asp Val Pro Leu Val Pro Pro Ala Leu 530 535 540 Gly Ala Asn Tyr Phe Ser Ser Ile Arg Gln Pro Val Val Gln His Ala 545 550 555 560 Arg Glu Ser Ala Ala Gly Glu Asn Ala Leu Thr Tyr Ala Leu Met Ala 565 570 575 Gly Tyr Phe Lys Met Ser Pro Val Ala Leu Tyr His Gln Leu Lys Thr 580 585 590 Gly Leu His Pro Gly Phe Gly Phe Thr Val Val Arg 595 600 <210> 13 <211> 683 <212> ДНК <213> Вирус иммунодефицита человека типа 1 <400> 13 cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc 60 ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt 120 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg 180 actggaaggg ctaattcact cccaacgaag acaagatatc cttgatctgt ggatctacca 240 cacacaaggc tacttccctg attggcagaa ctacacacca gggccaggga tcagatatcc 300 actgaccttt ggatggtgct acaagctagt accagttgag caagagaagg tagaagaagc 360 caatgaagga gagaacaccc gcttgttaca ccctgtgagc ctgcatggga tggatgaccc 420 ggagagagaa gtattagagt ggaggtttga cagccgccta gcatttcatc acatggcccg 480 agagctgcat ccggactgta ctgggtctct ctggttagac cagatctgag cctgggagct 540 ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca 600 agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta 660 gtcagtgtgg aaaatctcta gca 683 <210> 14 <211> 416 <212> ДНК <213> Вирус иммунодефицита человека типа 1 <400> 14 cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc 60 ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt 120 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg 180 actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgcct gtactgggtc 240 tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 300 taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 360 ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagca 416 <210> 15 <211> 401 <212> ДНК <213> Вирус иммунодефицита человека типа 1 <400> 15 cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc 60 ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt 120 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttactgg aagggctaat 180 tcactcccaa cgaagacaag atctgctttt tgcctgtact gggtctctct ggttagacca 240 gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag 300 cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag 360 atccctcaga cccttttagt cagtgtggaa aatctctagc a 401 <210> 16 <211> 4 <212> Белок <213> Фрагмент ВПГ-2 <400> 16 Cys Ala Lys Tyr 1 <210> 17 <211> 4 <212> Белок <213> Модифицированный фрагмент ВПГ-2 <400> 17 Gly Leu Ala Val 1