ПЕРЕЧЕНЬ ПОСЛЕДОВАТЕЛЬНОСТЕЙ <110> Йиссум ресерч девелопмент компани оф зе хебрев юниверсити оф Джерусалам лтд. Смарт резилин лтд. ШОСЕЙОВ, Одед ШАЛЕВ, Рони БАРУЧ-ШАРОН, Сигал БЕН ШАЛОМ, Тал НУТТМАН-НЕСИАЛ, Лирон <120> КОМПОЗИЦИИ ДЛЯ УХОДА ЗА ВОЛОСАМИ <130> 73407 <150> US 62/482,910 <151> 2017-04-07 <160> 21 <170> PatentIn version 3.5 <210> 1 <211> 324 <212> PRT <213> Искусственная последовательность <220> <223> Экзон 1 резилина от Drosophila melanogaster <400> 1 Met Gly Pro Glu Pro Pro Val Asn Ser Tyr Leu Pro Pro Ser Asp Ser 1 5 10 15 Tyr Gly Ala Pro Gly Gln Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser 20 25 30 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Ser Tyr 35 40 45 Gly Ala Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Tyr 50 55 60 Ala Gly Lys Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly 65 70 75 80 Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn 85 90 95 Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly 100 105 110 Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Gly Asn Gly 115 120 125 Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln 130 135 140 Gly Asn Gly Asn Gly Gly Arg Ser Ser Ser Ser Tyr Gly Ala Pro Gly 145 150 155 160 Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly 165 170 175 Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly 180 185 190 Asn Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly 195 200 205 Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 210 215 220 Gly Asn Gly Ser Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly 225 230 235 240 Gln Gly Gln Gly Gly Phe Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala 245 250 255 Pro Gly Gln Asn Gln Lys Pro Ser Asp Ser Tyr Gly Ala Pro Gly Ser 260 265 270 Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly 275 280 285 Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Pro Pro Ala Ser 290 295 300 Gly Ser Gly Ala Gly Gly Ala Gly Gly Ser Gly Pro Gly Gly Ala Asp 305 310 315 320 Tyr Asp Asn Asp <210> 2 <211> 323 <212> PRT <213> Искусственная последовательность <220> <223> Экзон 1 резилина от Drosophila melanogaster <400> 2 Gly Pro Glu Pro Pro Val Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr 1 5 10 15 Gly Ala Pro Gly Gln Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr 20 25 30 Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly 35 40 45 Ala Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala 50 55 60 Gly Lys Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn 65 70 75 80 Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly 85 90 95 Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly 100 105 110 Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn 115 120 125 Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly 130 135 140 Asn Gly Asn Gly Gly Arg Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly 145 150 155 160 Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly 165 170 175 Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 180 185 190 Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn 195 200 205 Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly 210 215 220 Asn Gly Ser Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln 225 230 235 240 Gly Gln Gly Gly Phe Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro 245 250 255 Gly Gln Asn Gln Lys Pro Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly 260 265 270 Asn Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser 275 280 285 Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly 290 295 300 Ser Gly Ala Gly Gly Ala Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr 305 310 315 320 Asp Asn Asp <210> 3 <211> 62 <212> PRT <213> Искусственная последовательность <220> <223> Связывающая хитин последовательность <400> 3 Glu Pro Ala Lys Tyr Glu Phe Asn Tyr Gln Val Glu Asp Ala Pro Ser 1 5 10 15 Gly Leu Ser Phe Gly His Ser Glu Met Arg Asp Gly Asp Phe Thr Thr 20 25 30 Gly Gln Tyr Asn Val Leu Leu Pro Asp Gly Arg Lys Gln Ile Val Glu 35 40 45 Tyr Glu Ala Asp Gln Gln Gly Tyr Arg Pro Gln Ile Arg Tyr 50 55 60 <210> 4 <211> 15 <212> PRT <213> Искусственная последовательность <220> <223> Повторяющаяся единица резилина <400> 4 Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gly Gly Asn 1 5 10 15 <210> 5 <211> 9 <212> PRT <213> Искусственная последовательность <220> <223> Повторяющаяся единица резилина <400> 5 Gly Arg Pro Ser Asp Ser Tyr Gly Ala 1 5 <210> 6 <211> 74 <212> PRT <213> Искусственная последовательность <220> <223> Связывающая хитин последовательность <400> 6 Pro Ala Lys Tyr Glu Phe Asn Tyr Gln Val Glu Asp Ala Pro Ser Gly 1 5 10 15 Leu Ser Phe Gly His Ser Glu Met Arg Asp Gly Asp Phe Thr Thr Gly 20 25 30 Gln Tyr Asn Val Leu Leu Pro Asp Gly Arg Lys Gln Ile Val Glu Tyr 35 40 45 Glu Ala Asp Gln Gln Gly Tyr Arg Pro Gln Ile Arg Tyr Glu Gly Asp 50 55 60 Ala Asn Asp Gly Ser Gly Pro Ser Gly Pro 65 70 <210> 7 <211> 900 <212> DNA <213> Искусственная последовательность <220> <223> Примеры полинуклеотидов, которые можно применять для экспрессии резилина <400> 7 agctatggag caccgggtca gagtggtccc ggcggcaggc cgtcggattc ctatggagct 60 cctggtggtg gaaacggtgg acggccctca gacagctatg gcgctccagg ccagggtcaa 120 ggacagggac aaggacaagg tggatatgca ggcaagccct cagataccta tggagctcct 180 ggtggtggaa atggcaacgg aggtcgtcca tcgagcagct atggcgctcc tggcggtgga 240 aacggtggtc gtccttcgga tacctacggt gctcctggtg gcggaaatgg tggacgccca 300 tcggacactt atggtgctcc tggtggtggt ggaaatggca acggcggacg accttcaagc 360 agctatggag ctcctggtca aggacaaggc aacggaaatg gcggtcgctc atcgagcagc 420 tatggtgctc ctggcggtgg aaacggcggt cgtccttcgg atacctacgg tgctcccggt 480 ggtggaaacg gtggtcgtcc ttcggatact tacggcgctc ctggtggcgg caataatggc 540 ggtcgtccct caagcagcta cggcgctcct ggtggtggaa acggtggtcg tccatctgac 600 acctatggcg ctcctggtgg cggtaacgga aacggcagcg gtggtcgtcc ttcaagcagc 660 tatggagctc ctggtcaggg ccaaggtgga tttggtggtc gtccatcgga ctcctatggt 720 gctcctggtc agaaccaaaa accatcagat tcatatggcg cccctggtag cggcaatggc 780 aacggcggac gtccttcgag cagctatgga gctccaggct caggacctgg tggccgaccc 840 tccgactcct acggaccccc agcttctgga tcgggagcag gtggcgctgg aggcagtgga 900 <210> 8 <211> 1080 <212> DNA <213> Искусственная последовательность <220> <223> Иллюстративная последовательность ДНК 6Н-меченного резилина (экзон 1) <400> 8 atgtcgtact accatcacca tcaccatcac gattacgata tcccaacgac cgaaaacctg 60 tattttcagg gcgccatggg accggagcca ccagttaact cgtatctacc tccgtccgat 120 agctatggag caccgggtca gagtggtccc ggcggcaggc cgtcggattc ctatggagct 180 cctggtggtg gaaacggtgg acggccctca gacagctatg gcgctccagg ccagggtcaa 240 ggacagggac aaggacaagg tggatatgca ggcaagccct cagataccta tggagctcct 300 ggtggtggaa atggcaacgg aggtcgtcca tcgagcagct atggcgctcc tggcggtgga 360 aacggtggtc gtccttcgga tacctacggt gctcctggtg gcggaaatgg tggacgccca 420 tcggacactt atggtgctcc tggtggtggt ggaaatggca acggcggacg accttcaagc 480 agctatggag ctcctggtca aggacaaggc aacggaaatg gcggtcgctc atcgagcagc 540 tatggtgctc ctggcggtgg aaacggcggt cgtccttcgg atacctacgg tgctcccggt 600 ggtggaaacg gtggtcgtcc ttcggatact tacggcgctc ctggtggcgg caataatggc 660 ggtcgtccct caagcagcta cggcgctcct ggtggtggaa acggtggtcg tccatctgac 720 acctatggcg ctcctggtgg cggtaacgga aacggcagcg gtggtcgtcc ttcaagcagc 780 tatggagctc ctggtcaggg ccaaggtgga tttggtggtc gtccatcgga ctcctatggt 840 gctcctggtc agaaccaaaa accatcagat tcatatggcg cccctggtag cggcaatggc 900 aacggcggac gtccttcgag cagctatgga gctccaggct caggacctgg tggccgaccc 960 tccgactcct acggaccccc agcttctgga tcgggagcag gtggcgctgg aggcagtgga 1020 cccggcggcg ctgactacga taacgatgag ggatccaatc actagtgaat tcgcggccgc 1080 <210> 9 <211> 354 <212> PRT <213> Искусственная последовательность <220> <223> Иллюстративная белковая последовательность 6Н-меченного резилина (экзон 1) <400> 9 Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 1 5 10 15 Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Gly Pro Glu Pro Pro Val 20 25 30 Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Ser 35 40 45 Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gly Gly 50 55 60 Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Gly Gln 65 70 75 80 Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala Gly Lys Pro Ser Asp Thr 85 90 95 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 100 105 110 Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr 115 120 125 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr 130 135 140 Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 145 150 155 160 Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Asn Gly Asn Gly Gly Arg 165 170 175 Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro 180 185 190 Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 195 200 205 Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Asn Gly Gly Arg Pro Ser 210 215 220 Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp 225 230 235 240 Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Ser Gly Gly Arg 245 250 255 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Gly Phe Gly 260 265 270 Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Asn Gln Lys Pro 275 280 285 Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly Asn Gly Asn Gly Gly Arg 290 295 300 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser Gly Pro Gly Gly Arg Pro 305 310 315 320 Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly Ser Gly Ala Gly Gly Ala 325 330 335 Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr Asp Asn Asp Glu Gly Ser 340 345 350 Asn His <210> 10 <211> 1311 <212> DNA <213> Искусственная последовательность <220> <223> Иллюстративная последовательность ДНК 6Н-меченного резилина (экзоны 1 и 2) <400> 10 catatgtcgt actaccatca ccatcaccat cacgattacg atatcccaac gaccgaaaac 60 ctgtattttc agggcgccat gggaccggag ccaccagtta actcgtatct acctccgtcc 120 gatagctatg gagcaccggg tcagagtggt cccggcggca ggccgtcgga ttcctatgga 180 gctcctggtg gtggaaacgg tggacggccc tcagacagct atggcgctcc aggccagggt 240 caaggacagg gacaaggaca aggtggatat gcaggcaagc cctcagatac ctatggagct 300 cctggtggtg gaaatggcaa cggaggtcgt ccatcgagca gctatggcgc tcctggcggt 360 ggaaacggtg gtcgtccttc ggatacctac ggtgctcctg gtggcggaaa tggtggacgc 420 ccatcggaca cttatggtgc tcctggtggt ggtggaaatg gcaacggcgg acgaccttca 480 agcagctatg gagctcctgg tcaaggacaa ggcaacggaa atggcggtcg ctcatcgagc 540 agctatggtg ctcctggcgg tggaaacggc ggtcgtcctt cggataccta cggtgctccc 600 ggtggtggaa acggtggtcg tccttcggat acttacggcg ctcctggtgg cggcaataat 660 ggcggtcgtc cctcaagcag ctacggcgct cctggtggtg gaaacggtgg tcgtccatct 720 gacacctatg gcgctcctgg tggcggtaac ggaaacggca gcggtggtcg tccttcaagc 780 agctatggag ctcctggtca gggccaaggt ggatttggtg gtcgtccatc ggactcctat 840 ggtgctcctg gtcagaacca aaaaccatca gattcatatg gcgcccctgg tagcggcaat 900 ggcaacggcg gacgtccttc gagcagctat ggagctccag gctcaggacc tggtggccga 960 ccctccgact cctacggacc cccagcttct ggatcgggag caggtggcgc tggaggcagt 1020 ggacccggcg gcgctgacta cgataacgat gagcccgcca agtacgaatt taattaccag 1080 gttgaggacg cgcccagcgg actctcgttc gggcattcag agatgcgcga cggtgacttc 1140 accaccggcc agtacaatgt cctgttgccc gacggaagga agcaaattgt ggagtatgaa 1200 gccgaccagc agggctaccg gccacagatc cgctacgaag gcgatgccaa cgatggcagt 1260 ggtcccagcg gtccttaagg atccgagctc cgtcgacaag cttgcggccg c 1311 <210> 11 <211> 424 <212> PRT <213> Искусственная последовательность <220> <223> Иллюстративная белковая последовательность 6Н-меченного резилина (экзоны 1 и 2) <400> 11 Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 1 5 10 15 Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Gly Pro Glu Pro Pro Val 20 25 30 Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Ser 35 40 45 Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gly Gly 50 55 60 Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Gly Gln 65 70 75 80 Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala Gly Lys Pro Ser Asp Thr 85 90 95 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 100 105 110 Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr 115 120 125 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr 130 135 140 Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 145 150 155 160 Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Asn Gly Asn Gly Gly Arg 165 170 175 Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro 180 185 190 Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 195 200 205 Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Asn Gly Gly Arg Pro Ser 210 215 220 Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp 225 230 235 240 Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Ser Gly Gly Arg 245 250 255 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Gly Phe Gly 260 265 270 Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Asn Gln Lys Pro 275 280 285 Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly Asn Gly Asn Gly Gly Arg 290 295 300 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser Gly Pro Gly Gly Arg Pro 305 310 315 320 Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly Ser Gly Ala Gly Gly Ala 325 330 335 Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr Asp Asn Asp Glu Pro Ala 340 345 350 Lys Tyr Glu Phe Asn Tyr Gln Val Glu Asp Ala Pro Ser Gly Leu Ser 355 360 365 Phe Gly His Ser Glu Met Arg Asp Gly Asp Phe Thr Thr Gly Gln Tyr 370 375 380 Asn Val Leu Leu Pro Asp Gly Arg Lys Gln Ile Val Glu Tyr Glu Ala 385 390 395 400 Asp Gln Gln Gly Tyr Arg Pro Gln Ile Arg Tyr Glu Gly Asp Ala Asn 405 410 415 Asp Gly Ser Gly Pro Ser Gly Pro 420 <210> 12 <211> 1580 <212> DNA <213> Искусственная последовательность <220> <223> Иллюстративная последовательность ДНК 6Н-меченного резилина (экзон 1), слитого со связывающим целлюлозу доменом (CBD) <400> 12 catatgtcgt actaccatca ccatcaccat cacgattacg atatcccaac gaccgaaaac 60 ctgtattttc agggcgccat gggaccggag ccaccagtta actcgtatct acctccgtcc 120 gatagctatg gagcaccggg tcagagtggt cccggcggca ggccgtcgga ttcctatgga 180 gctcctggtg gtggaaacgg tggacggccc tcagacagct atggcgctcc aggccagggt 240 caaggacagg gacaaggaca aggtggatat gcaggcaagc cctcagatac ctatggagct 300 cctggtggtg gaaatggcaa cggaggtcgt ccatcgagca gctatggcgc tcctggcggt 360 ggaaacggtg gtcgtccttc ggatacctac ggtgctcctg gtggcggaaa tggtggacgc 420 ccatcggaca cttatggtgc tcctggtggt ggtggaaatg gcaacggcgg acgaccttca 480 agcagctatg gagctcctgg tcaaggacaa ggcaacggaa atggcggtcg ctcatcgagc 540 agctatggtg ctcctggcgg tggaaacggc ggtcgtcctt cggataccta cggtgctccc 600 ggtggtggaa acggtggtcg tccttcggat acttacggcg ctcctggtgg cggcaataat 660 ggcggtcgtc cctcaagcag ctacggcgct cctggtggtg gaaacggtgg tcgtccatct 720 gacacctatg gcgctcctgg tggcggtaac ggaaacggca gcggtggtcg tccttcaagc 780 agctatggag ctcctggtca gggccaaggt ggatttggtg gtcgtccatc ggactcctat 840 ggtgctcctg gtcagaacca aaaaccatca gattcatatg gcgcccctgg tagcggcaat 900 ggcaacggcg gacgtccttc gagcagctat ggagctccag gctcaggacc tggtggccga 960 ccctccgact cctacggacc cccagcttct ggatcgggag caggtggcgc tggaggcagt 1020 ggacccggcg gcgctgacta cgataacgat gaggggatcc ccgaccccgg catggcagcg 1080 acatcatcaa tgtcagttga attttacaac tctaacaaat cagcacaaac aaactcaatt 1140 acaccaataa tcaaaattac taacacatct gacagtgatt taaatttaaa tgacgtaaaa 1200 gttagatatt attacacaag tgatggtaca caaggacaaa ctttctggtg tgaccatgct 1260 ggtgcattat taggaaatag ctatgttgat aacactagca aagtgacagc aaacttcgtt 1320 aaagaaacag caagcccaac atcaacctat gatacatatg ttgaatttgg atttgcaagc 1380 ggacgagcta ctcttaaaaa aggacaattt ataactattc aaggaagaat aacaaaatca 1440 gactggtcaa actacactca aacaaatgac tattcatttg atgcaagtag ttcaacacca 1500 gttgtaaatc caaaagttac aggatatata ggtggagcta aagtacttgg tacagcacca 1560 taggatcgat ccagatgtac 1580 <210> 13 <211> 519 <212> PRT <213> Искусственная последовательность <220> <223> Иллюстративная белковая последовательность 6Н-меченного резилина (экзон 1), слитого со связывающим целлюлозу доменом (CBD) <400> 13 Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 1 5 10 15 Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Gly Pro Glu Pro Pro Val 20 25 30 Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Ser 35 40 45 Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gly Gly 50 55 60 Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Gly Gln 65 70 75 80 Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala Gly Lys Pro Ser Asp Thr 85 90 95 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 100 105 110 Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr 115 120 125 Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr 130 135 140 Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser 145 150 155 160 Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Asn Gly Asn Gly Gly Arg 165 170 175 Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro 180 185 190 Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 195 200 205 Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Asn Gly Gly Arg Pro Ser 210 215 220 Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp 225 230 235 240 Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Ser Gly Gly Arg 245 250 255 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Gly Phe Gly 260 265 270 Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Asn Gln Lys Pro 275 280 285 Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly Asn Gly Asn Gly Gly Arg 290 295 300 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser Gly Pro Gly Gly Arg Pro 305 310 315 320 Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly Ser Gly Ala Gly Gly Ala 325 330 335 Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr Asp Asn Asp Glu Gly Ile 340 345 350 Pro Asp Pro Gly Met Ala Ala Thr Ser Ser Met Ser Val Glu Phe Tyr 355 360 365 Asn Ser Asn Lys Ser Ala Gln Thr Asn Ser Ile Thr Pro Ile Ile Lys 370 375 380 Ile Thr Asn Thr Ser Asp Ser Asp Leu Asn Leu Asn Asp Val Lys Val 385 390 395 400 Arg Tyr Tyr Tyr Thr Ser Asp Gly Thr Gln Gly Gln Thr Phe Trp Cys 405 410 415 Asp His Ala Gly Ala Leu Leu Gly Asn Ser Tyr Val Asp Asn Thr Ser 420 425 430 Lys Val Thr Ala Asn Phe Val Lys Glu Thr Ala Ser Pro Thr Ser Thr 435 440 445 Tyr Asp Thr Tyr Val Glu Phe Gly Phe Ala Ser Gly Arg Ala Thr Leu 450 455 460 Lys Lys Gly Gln Phe Ile Thr Ile Gln Gly Arg Ile Thr Lys Ser Asp 465 470 475 480 Trp Ser Asn Tyr Thr Gln Thr Asn Asp Tyr Ser Phe Asp Ala Ser Ser 485 490 495 Ser Thr Pro Val Val Asn Pro Lys Val Thr Gly Tyr Ile Gly Gly Ala 500 505 510 Lys Val Leu Gly Thr Ala Pro 515 <210> 14 <211> 1620 <212> DNA <213> Искусственная последовательность <220> <223> Иллюстративная последовательность ДНК 6Н-меченного резилина (экзон 1), слитого со связывающим целлюлозу доменом (CBD) <400> 14 catatgtcgt actaccatca ccatcaccat cacgattacg atatcccaac gaccgaaaac 60 ctgtattttc agggcgccat ggcagcgaca tcatcaatgt cagttgaatt ttacaactct 120 aacaaagcag cacaaacaaa ctcaattaca ccaataatca aaattactaa cacagctgac 180 agtgatttaa atttaaatga cgtaaaagtt agatattatt acacaagtga tggtacacaa 240 ggacaaactt tctggggtga tcatgctggt gcattattag gaaatagcta tgttgataac 300 actggcaaag tgacagcaaa cttcgttaaa gaaacagcaa gcccaacatc aacctatgat 360 acatatgttg aatttggatt tgcaagcgga gcagctactc ttaaaaaagg acaatttata 420 actattcaag gaagaataac aaaatcagac tggtcaaact acgctcagac aaatgactat 480 tcatttgatg caagtagttc aacaccagtt gtaaatccaa aagttacagg atatataggt 540 ggagctaaag tacttggtac agcaccaggt ccagatgtac catcttcaat aattaatcct 600 acttctgcaa catttgatcc ggagccacca gttaactcgt atctacctcc gtccgatagc 660 tatggagcac cgggtcagag tggtcccggc ggcaggccgt cggattccta tggagctcct 720 ggtggtggaa acggtggacg gccctcagac agctatggcg ctccaggcca gggtcaagga 780 cagggacaag gacaaggtgg atatgcaggc aagccctcag atacctatgg agctcctggt 840 ggtggaaatg gcaacggagg tcgtccatcg agcagctatg gcgctcctgg cggtggaaac 900 ggtggtcgtc cttcggatac ctacggtgct cctggtggcg gaaatggtgg acgcccatcg 960 gacacttatg gtgctcctgg tggtggtgga aatggcaacg gcggacgacc ttcaagcagc 1020 tatggagctc ctggtcaagg acaaggcaac ggaaatggcg gtcgctcatc gagcagctat 1080 ggtgctcctg gcggtggaaa cggcggtcgt ccttcggata cctacggtgc tcccggtggt 1140 ggaaacggtg gtcgtccttc ggatacttac ggcgctcctg gtggcggcaa taatggcggt 1200 cgtccctcaa gcagctacgg cgctcctggt ggtggaaacg gtggtcgtcc atctgacacc 1260 tatggcgctc ctggtggcgg taacggaaac ggcagcggtg gtcgtccttc aagcagctat 1320 ggagctcctg gtcagggcca aggtggattt ggtggtcgtc catcggactc ctatggtgct 1380 cctggtcaga accaaaaacc atcagattca tatggcgccc ctggtagcgg caatggcaac 1440 ggcggacgtc cttcgagcag ctatggagct ccaggctcag gacctggtgg ccgaccctcc 1500 gactcctacg gacccccagc ttctggatcg ggagcaggtg gcgctggagg cagtggaccc 1560 ggcggcgctg actacgataa cgatgagtaa ggatccgagc tccgtcgaca agcttgcggc 1620 <210> 15 <211> 528 <212> PRT <213> Искусственная последовательность <220> <223> Иллюстративная белковая последовательность 6Н-меченного резилина (экзон 1), слитого со связывающим целлюлозу доменом (CBD) <400> 15 Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 1 5 10 15 Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Ala Ala Thr Ser Ser Met 20 25 30 Ser Val Glu Phe Tyr Asn Ser Asn Lys Ala Ala Gln Thr Asn Ser Ile 35 40 45 Thr Pro Ile Ile Lys Ile Thr Asn Thr Ala Asp Ser Asp Leu Asn Leu 50 55 60 Asn Asp Val Lys Val Arg Tyr Tyr Tyr Thr Ser Asp Gly Thr Gln Gly 65 70 75 80 Gln Thr Phe Trp Gly Asp His Ala Gly Ala Leu Leu Gly Asn Ser Tyr 85 90 95 Val Asp Asn Thr Gly Lys Val Thr Ala Asn Phe Val Lys Glu Thr Ala 100 105 110 Ser Pro Thr Ser Thr Tyr Asp Thr Tyr Val Glu Phe Gly Phe Ala Ser 115 120 125 Gly Ala Ala Thr Leu Lys Lys Gly Gln Phe Ile Thr Ile Gln Gly Arg 130 135 140 Ile Thr Lys Ser Asp Trp Ser Asn Tyr Ala Gln Thr Asn Asp Tyr Ser 145 150 155 160 Phe Asp Ala Ser Ser Ser Thr Pro Val Val Asn Pro Lys Val Thr Gly 165 170 175 Tyr Ile Gly Gly Ala Lys Val Leu Gly Thr Ala Pro Gly Pro Asp Val 180 185 190 Pro Ser Ser Ile Ile Asn Pro Thr Ser Ala Thr Phe Asp Pro Glu Pro 195 200 205 Pro Val Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr Gly Ala Pro Gly 210 215 220 Gln Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly 225 230 235 240 Gly Gly Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln 245 250 255 Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala Gly Lys Pro Ser 260 265 270 Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro 275 280 285 Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 290 295 300 Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp 305 310 315 320 Thr Tyr Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn Gly Gly Arg Pro 325 330 335 Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Asn Gly Asn Gly 340 345 350 Gly Arg Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly 355 360 365 Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg 370 375 380 Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Asn Gly Gly Arg 385 390 395 400 Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro 405 410 415 Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn Gly Ser Gly 420 425 430 Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly Gly 435 440 445 Phe Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro Gly Gln Asn Gln 450 455 460 Lys Pro Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly Asn Gly Asn Gly 465 470 475 480 Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser Gly Pro Gly Gly 485 490 495 Arg Pro Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly Ser Gly Ala Gly 500 505 510 Gly Ala Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr Asp Asn Asp Glu 515 520 525 <210> 16 <211> 324 <212> PRT <213> Искусственная последовательность <220> <223> Экзон 1 резилина <400> 16 Gly Pro Glu Pro Pro Val Asn Ser Tyr Leu Pro Pro Ser Asp Ser Tyr 1 5 10 15 Gly Ala Pro Gly Gln Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr 20 25 30 Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Ser Tyr Gly 35 40 45 Ala Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Tyr Ala 50 55 60 Gly Lys Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Asn 65 70 75 80 Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly 85 90 95 Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly 100 105 110 Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Gly Asn Gly Asn 115 120 125 Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly Gln Gly 130 135 140 Asn Gly Asn Gly Gly Arg Ser Ser Ser Ser Tyr Gly Ala Pro Gly Gly 145 150 155 160 Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly 165 170 175 Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 180 185 190 Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly Asn 195 200 205 Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly 210 215 220 Asn Gly Ser Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln 225 230 235 240 Gly Gln Gly Gly Phe Gly Gly Arg Pro Ser Asp Ser Tyr Gly Ala Pro 245 250 255 Gly Gln Asn Gln Lys Pro Ser Asp Ser Tyr Gly Ala Pro Gly Ser Gly 260 265 270 Asn Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Ser 275 280 285 Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Pro Pro Ala Ser Gly 290 295 300 Ser Gly Ala Gly Gly Ala Gly Gly Ser Gly Pro Gly Gly Ala Asp Tyr 305 310 315 320 Asp Asn Asp Glu <210> 17 <211> 180 <212> PRT <213> Искусственная последовательность <220> <223> Белковая последовательность связывающего целлюлозу домена <400> 17 Met Ala Ala Thr Ser Ser Met Ser Val Glu Phe Tyr Asn Ser Asn Lys 1 5 10 15 Ala Ala Gln Thr Asn Ser Ile Thr Pro Ile Ile Lys Ile Thr Asn Thr 20 25 30 Ala Asp Ser Asp Leu Asn Leu Asn Asp Val Lys Val Arg Tyr Tyr Tyr 35 40 45 Thr Ser Asp Gly Thr Gln Gly Gln Thr Phe Trp Gly Asp His Ala Gly 50 55 60 Ala Leu Leu Gly Asn Ser Tyr Val Asp Asn Thr Gly Lys Val Thr Ala 65 70 75 80 Asn Phe Val Lys Glu Thr Ala Ser Pro Thr Ser Thr Tyr Asp Thr Tyr 85 90 95 Val Glu Phe Gly Phe Ala Ser Gly Ala Ala Thr Leu Lys Lys Gly Gln 100 105 110 Phe Ile Thr Ile Gln Gly Arg Ile Thr Lys Ser Asp Trp Ser Asn Tyr 115 120 125 Ala Gln Thr Asn Asp Tyr Ser Phe Asp Ala Ser Ser Ser Thr Pro Val 130 135 140 Val Asn Pro Lys Val Thr Gly Tyr Ile Gly Gly Ala Lys Val Leu Gly 145 150 155 160 Thr Ala Pro Gly Pro Asp Val Pro Ser Ser Ile Ile Asn Pro Thr Ser 165 170 175 Ala Thr Phe Asp 180 <210> 18 <211> 163 <212> PRT <213> Искусственная последовательность <220> <223> Белковая последовательность связывающего целлюлозу домена <400> 18 Met Ala Ala Thr Ser Ser Met Ser Val Glu Phe Tyr Asn Ser Asn Lys 1 5 10 15 Ala Ala Gln Thr Asn Ser Ile Thr Pro Ile Ile Lys Ile Thr Asn Thr 20 25 30 Ala Asp Ser Asp Leu Asn Leu Asn Asp Val Lys Val Arg Tyr Tyr Tyr 35 40 45 Thr Ser Asp Gly Thr Gln Gly Gln Thr Phe Trp Gly Asp His Ala Gly 50 55 60 Ala Leu Leu Gly Asn Ser Tyr Val Asp Asn Thr Gly Lys Val Thr Ala 65 70 75 80 Asn Phe Val Lys Glu Thr Ala Ser Pro Thr Ser Thr Tyr Asp Thr Tyr 85 90 95 Val Glu Phe Gly Phe Ala Ser Gly Ala Ala Thr Leu Lys Lys Gly Gln 100 105 110 Phe Ile Thr Ile Gln Gly Arg Ile Thr Lys Ser Asp Trp Ser Asn Tyr 115 120 125 Ala Gln Thr Asn Asp Tyr Ser Phe Asp Ala Ser Ser Ser Thr Pro Val 130 135 140 Val Asn Pro Lys Val Thr Gly Tyr Ile Gly Gly Ala Lys Val Leu Gly 145 150 155 160 Thr Ala Pro <210> 19 <211> 605 <212> PRT <213> Drosophila melanogaster <400> 19 Met Val Arg Pro Glu Pro Pro Val Asn Ser Tyr Leu Pro Pro Ser Asp 1 5 10 15 Ser Tyr Gly Ala Pro Gly Gln Ser Gly Pro Gly Gly Arg Pro Ser Asp 20 25 30 Ser Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Ser 35 40 45 Tyr Gly Ala Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly 50 55 60 Tyr Ala Gly Lys Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 65 70 75 80 Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly Gly 85 90 95 Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 100 105 110 Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Gly Asn 115 120 125 Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gln Gly 130 135 140 Gln Gly Asn Gly Asn Gly Gly Arg Ser Ser Ser Ser Tyr Gly Ala Pro 145 150 155 160 Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly 165 170 175 Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly 180 185 190 Gly Asn Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro Gly Gly 195 200 205 Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly 210 215 220 Asn Gly Asn Gly Ser Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro 225 230 235 240 Gly Gln Gly Gln Gly Gly Phe Gly Gly Arg Pro Ser Asp Ser Tyr Gly 245 250 255 Ala Pro Gly Gln Asn Gln Lys Pro Ser Asp Ser Tyr Gly Ala Pro Gly 260 265 270 Ser Gly Asn Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ala Pro 275 280 285 Gly Ser Gly Pro Gly Gly Arg Pro Ser Asp Ser Tyr Gly Pro Pro Ala 290 295 300 Ser Gly Ser Gly Ala Gly Gly Ala Gly Gly Ser Gly Pro Gly Gly Ala 305 310 315 320 Asp Tyr Asp Asn Asp Glu Pro Ala Lys Tyr Glu Phe Asn Tyr Gln Val 325 330 335 Glu Asp Ala Pro Ser Gly Leu Ser Phe Gly His Ser Glu Met Arg Asp 340 345 350 Gly Asp Phe Thr Thr Gly Gln Tyr Asn Val Leu Leu Pro Asp Gly Arg 355 360 365 Lys Gln Ile Val Glu Tyr Glu Ala Asp Gln Gln Gly Tyr Arg Pro Gln 370 375 380 Ile Arg Tyr Glu Gly Asp Ala Asn Asp Gly Ser Gly Pro Ser Gly Pro 385 390 395 400 Gly Gly Pro Gly Gly Gln Asn Leu Gly Ala Asp Gly Tyr Ser Ser Gly 405 410 415 Arg Pro Gly Asn Gly Asn Gly Asn Gly Asn Gly Gly Tyr Ser Gly Gly 420 425 430 Arg Pro Gly Gly Gln Asp Leu Gly Pro Ser Gly Tyr Ser Gly Gly Arg 435 440 445 Pro Gly Gly Gln Asp Leu Gly Ala Gly Gly Tyr Ser Asn Gly Lys Pro 450 455 460 Gly Gly Gln Asp Leu Gly Pro Gly Gly Tyr Ser Gly Gly Arg Pro Gly 465 470 475 480 Gly Gln Asp Leu Gly Arg Asp Gly Tyr Ser Gly Gly Arg Pro Gly Gly 485 490 495 Gln Asp Leu Gly Ala Ser Gly Tyr Ser Asn Gly Arg Pro Gly Gly Asn 500 505 510 Gly Asn Gly Gly Ser Asp Gly Gly Arg Val Ile Ile Gly Gly Arg Val 515 520 525 Ile Gly Gly Gln Asp Gly Gly Asp Gln Gly Tyr Ser Gly Gly Arg Pro 530 535 540 Gly Gly Gln Asp Leu Gly Arg Asp Gly Tyr Ser Ser Gly Arg Pro Gly 545 550 555 560 Gly Arg Pro Gly Gly Asn Gly Gln Asp Ser Gln Asp Gly Gln Gly Tyr 565 570 575 Ser Ser Gly Arg Pro Gly Gln Gly Gly Arg Asn Gly Phe Gly Pro Gly 580 585 590 Gly Gln Asn Gly Asp Asn Asp Gly Ser Gly Tyr Arg Tyr 595 600 605 <210> 20 <211> 7 <212> PRT <213> Искусственная последовательность <220> <223> Повторы консенсусной аминокислотной последовательности резилина <220> <221> misc_feature <222> (2)..(3) <223> Xaa может быть любой встречающейся в природе аминокислотой <220> <221> misc_feature <222> (6)..(6) <223> Xaa может быть любой встречающейся в природе аминокислотой <400> 20 Ser Xaa Xaa Tyr Gly Xaa Pro 1 5 <210> 21 <211> 1848 <212> PRT <213> Clostridium cellulovorans <400> 21 Met Gln Lys Lys Lys Ser Leu Asn Leu Leu Leu Ala Leu Met Met Val 1 5 10 15 Phe Ala Leu Val Leu Pro Ser Ile Pro Ala Leu Ala Ala Thr Ser Ser 20 25 30 Met Ser Val Glu Phe Tyr Asn Ser Asn Lys Ser Ala Gln Thr Asn Ser 35 40 45 Ile Thr Pro Ile Ile Lys Ile Thr Asn Thr Ser Asp Ser Asp Leu Asn 50 55 60 Leu Asn Asp Val Lys Val Arg Tyr Tyr Tyr Thr Ser Asp Gly Thr Gln 65 70 75 80 Gly Gln Thr Phe Trp Cys Asp His Ala Gly Ala Leu Leu Gly Asn Ser 85 90 95 Tyr Val Asp Asn Thr Ser Lys Val Thr Ala Asn Phe Val Lys Glu Thr 100 105 110 Ala Ser Pro Thr Ser Thr Tyr Asp Thr Tyr Val Glu Phe Gly Phe Ala 115 120 125 Ser Gly Arg Ala Thr Leu Lys Lys Gly Gln Phe Ile Thr Ile Gln Gly 130 135 140 Arg Ile Thr Lys Ser Asp Trp Ser Asn Tyr Thr Gln Thr Asn Asp Tyr 145 150 155 160 Ser Phe Asp Ala Ser Ser Ser Thr Pro Val Val Asn Pro Lys Val Thr 165 170 175 Gly Tyr Ile Gly Gly Ala Lys Val Leu Gly Thr Ala Pro Gly Pro Asp 180 185 190 Val Pro Ser Ser Ile Ile Asn Pro Thr Ser Ala Thr Phe Asp Lys Asn 195 200 205 Val Thr Lys Gln Ala Asp Val Lys Thr Thr Met Thr Leu Asn Gly Asn 210 215 220 Thr Phe Lys Thr Ile Thr Asp Ala Asn Gly Thr Ala Leu Asn Ala Ser 225 230 235 240 Thr Asp Tyr Ser Val Ser Gly Asn Asp Val Thr Ile Ser Lys Ala Tyr 245 250 255 Leu Ala Lys Gln Ser Val Gly Thr Thr Thr Leu Asn Phe Asn Phe Ser 260 265 270 Ala Gly Asn Pro Gln Lys Leu Val Ile Thr Val Val Asp Thr Pro Val 275 280 285 Glu Ala Val Thr Ala Thr Ile Gly Lys Val Gln Val Asn Ala Gly Glu 290 295 300 Thr Val Ala Val Pro Val Asn Leu Thr Lys Val Pro Ala Ala Gly Leu 305 310 315 320 Ala Thr Ile Glu Leu Pro Leu Thr Phe Asp Ser Ala Ser Leu Glu Val 325 330 335 Val Ser Ile Thr Ala Gly Asp Ile Val Leu Asn Pro Ser Val Asn Phe 340 345 350 Ser Ser Thr Val Ser Gly Ser Thr Ile Lys Leu Leu Phe Leu Asp Asp 355 360 365 Thr Leu Gly Ser Gln Leu Ile Thr Lys Asp Gly Val Phe Ala Thr Ile 370 375 380 Thr Phe Lys Ala Lys Ala Ile Thr Gly Thr Thr Ala Lys Val Thr Ser 385 390 395 400 Val Lys Leu Ala Gly Thr Pro Val Val Gly Asp Ala Gln Leu Gln Glu 405 410 415 Lys Pro Cys Ala Val Asn Pro Gly Thr Val Thr Ile Asn Pro Ile Asp 420 425 430 Asn Arg Met Gln Ile Ser Val Gly Thr Ala Thr Val Lys Ala Gly Glu 435 440 445 Ile Ala Ala Val Pro Val Thr Leu Thr Ser Val Pro Ser Thr Gly Ile 450 455 460 Ala Thr Ala Glu Ala Gln Val Ser Phe Asp Ala Thr Leu Leu Glu Val 465 470 475 480 Ala Ser Val Thr Ala Gly Asp Ile Val Leu Asn Pro Thr Val Asn Phe 485 490 495 Ser Tyr Thr Val Asn Gly Asn Val Ile Lys Leu Leu Phe Leu Asp Asp 500 505 510 Thr Leu Gly Ser Gln Leu Ile Ser Lys Asp Gly Val Phe Val Thr Ile 515 520 525 Asn Phe Lys Ala Lys Ala Val Thr Ser Thr Val Thr Thr Pro Val Thr 530 535 540 Val Ser Gly Thr Pro Val Phe Ala Asp Gly Thr Leu Ala Glu Val Gln 545 550 555 560 Ser Lys Thr Ala Ala Gly Ser Val Thr Ile Asn Ile Gly Asp Pro Ile 565 570 575 Leu Glu Pro Thr Ile Ser Pro Val Thr Ala Thr Phe Asp Lys Lys Ala 580 585 590 Pro Ala Asp Val Ala Thr Thr Met Thr Leu Asn Gly Tyr Thr Phe Asn 595 600 605 Gly Ile Thr Gly Leu Thr Thr Ser Asp Tyr Ser Ile Ser Gly Asn Val 610 615 620 Val Lys Ile Ser Gln Ala Tyr Leu Ala Lys Gln Pro Val Gly Asp Leu 625 630 635 640 Thr Leu Thr Phe Asn Phe Ser Asn Gly Asn Lys Thr Ala Thr Ala Lys 645 650 655 Leu Val Val Ser Ile Lys Asp Ala Pro Lys Thr Val Thr Ala Thr Val 660 665 670 Gly Thr Ala Thr Val Asn Ala Gly Glu Thr Val Ala Val Pro Val Thr 675 680 685 Leu Ser Asn Val Ser Gly Ile Ser Thr Ala Glu Leu Gln Leu Ser Phe 690 695 700 Asp Ala Thr Leu Leu Glu Val Val Ser Ile Thr Ala Gly Asp Ile Val 705 710 715 720 Leu Asn Pro Ser Val Asn Phe Ser Ser Val Val Asn Gly Ser Thr Ile 725 730 735 Lys Leu Leu Phe Leu Asp Asp Thr Leu Gly Ser Gln Leu Ile Ser Lys 740 745 750 Asp Gly Val Phe Ala Thr Ile Asn Phe Lys Ala Lys Ser Val Thr Ser 755 760 765 Thr Val Thr Thr Pro Val Lys Val Ser Gly Thr Pro Val Phe Ala Asp 770 775 780 Gly Thr Leu Ala Glu Leu Ser Tyr Glu Thr Val Ala Gly Ser Val Thr 785 790 795 800 Ile Asn Ala Ile Gly Pro Val Lys Thr Val Thr Ala Thr Val Gly Thr 805 810 815 Ala Thr Val Lys Ser Gly Glu Thr Val Ala Val Pro Val Thr Leu Ser 820 825 830 Asn Val Pro Gly Ile Ala Thr Ala Glu Leu Gln Leu Ser Phe Asp Ala 835 840 845 Thr Leu Leu Glu Val Ala Ser Ile Thr Val Gly Asp Ile Val Leu Asn 850 855 860 Pro Ser Val Asn Phe Ser Ser Val Val Asn Gly Ser Thr Ile Lys Leu 865 870 875 880 Leu Phe Leu Asp Asp Thr Leu Gly Ser Gln Leu Ile Ser Lys Asp Gly 885 890 895 Val Leu Ala Thr Ile Asn Phe Lys Ala Lys Thr Val Thr Ser Thr Val 900 905 910 Thr Thr Pro Val Ala Val Ser Gly Thr Pro Val Phe Ala Asp Gly Thr 915 920 925 Leu Ala Glu Leu Gln Ser Lys Thr Val Ala Gly Ser Val Thr Ile Glu 930 935 940 Pro Ser Gln Pro Val Lys Thr Val Thr Ala Thr Val Gly Thr Ala Thr 945 950 955 960 Val Lys Ser Gly Glu Thr Val Ala Val Pro Val Thr Leu Ser Asn Val 965 970 975 Pro Gly Ile Ala Thr Ala Glu Leu Gln Val Gly Phe Asp Ala Thr Leu 980 985 990 Leu Glu Val Ala Ser Ile Thr Val Gly Asp Ile Val Leu Asn Pro Ser 995 1000 1005 Val Asn Phe Ser Ser Val Val Asn Gly Ser Thr Ile Lys Leu Leu 1010 1015 1020 Phe Leu Asp Asp Thr Leu Gly Ser Gln Leu Ile Ser Lys Asp Gly 1025 1030 1035 Val Leu Ala Thr Ile Asn Phe Lys Ala Lys Thr Val Thr Ser Lys 1040 1045 1050 Val Thr Thr Pro Val Ala Val Ser Gly Thr Pro Val Phe Ala Asp 1055 1060 1065 Gly Thr Leu Ala Glu Leu Asn Met Lys Thr Val Ala Gly Ser Val 1070 1075 1080 Thr Ile Glu Pro Ser Gln Pro Val Lys Thr Val Thr Ala Thr Val 1085 1090 1095 Gly Thr Ala Thr Val Lys Ser Gly Glu Thr Val Ala Val Pro Val 1100 1105 1110 Thr Leu Ser Asn Val Pro Gly Ile Ala Thr Ala Glu Leu Gln Val 1115 1120 1125 Gly Phe Asp Ala Thr Leu Leu Glu Val Ala Ser Ile Thr Val Gly 1130 1135 1140 Asp Ile Val Leu Asn Pro Ser Val Asn Phe Ser Ser Val Val Asn 1145 1150 1155 Gly Ser Thr Ile Lys Leu Leu Phe Leu Asp Asp Thr Leu Gly Ser 1160 1165 1170 Gln Leu Ile Ser Lys Asp Gly Val Leu Ala Thr Ile Asn Phe Lys 1175 1180 1185 Ala Lys Thr Val Thr Ser Lys Val Thr Thr Pro Val Ala Val Ser 1190 1195 1200 Gly Thr Pro Val Phe Ala Asp Gly Thr Leu Ala Glu Leu Lys Tyr 1205 1210 1215 Glu Thr Val Ala Gly Ser Val Thr Ile Glu Pro Ser Gln Pro Val 1220 1225 1230 Lys Thr Val Thr Ala Thr Val Gly Thr Ala Thr Gly Lys Val Gly 1235 1240 1245 Glu Thr Val Ala Val Pro Val Thr Leu Ser Asn Val Pro Gly Ile 1250 1255 1260 Ala Thr Ala Glu Val Gln Val Gly Phe Asp Ala Thr Leu Leu Glu 1265 1270 1275 Val Ala Ser Ile Thr Ala Gly Asp Ile Val Leu Asn Pro Ser Val 1280 1285 1290 Asn Phe Ser Ser Val Val Asn Gly Ser Thr Ile Lys Ile Leu Phe 1295 1300 1305 Leu Asp Asp Thr Leu Gly Ser Gln Leu Ile Ser Lys Asp Gly Val 1310 1315 1320 Phe Ala Thr Ile Asn Phe Lys Ile Lys Ala Val Pro Ser Thr Gly 1325 1330 1335 Thr Thr Pro Val Ala Ile Ser Gly Thr Pro Val Phe Ala Asp Gly 1340 1345 1350 Thr Leu Ala Glu Val Gln Tyr Lys Thr Val Ala Gly Ser Val Thr 1355 1360 1365 Ile Ala Ala Ala Asp Ile Lys Ala Val Lys Ala Thr Val Gly Thr 1370 1375 1380 Ala Thr Gly Lys Ala Gly Asp Thr Val Ala Val Pro Val Thr Leu 1385 1390 1395 Ser Asn Val Ser Gly Ile Ala Thr Val Glu Leu Gln Leu Ser Phe 1400 1405 1410 Asp Ala Thr Leu Leu Glu Val Ala Ser Ile Thr Ala Gly Asp Ile 1415 1420 1425 Val Leu Asn Pro Ser Val Asn Phe Ser Ser Val Val Asn Gly Ser 1430 1435 1440 Thr Ile Lys Ile Leu Phe Leu Asp Asp Thr Leu Gly Ser Gln Leu 1445 1450 1455 Ile Ser Lys Asp Gly Val Phe Ala Thr Val Asn Phe Lys Val Lys 1460 1465 1470 Ser Thr Ala Thr Asn Ser Ala Val Thr Pro Val Thr Val Ser Gly 1475 1480 1485 Thr Pro Val Phe Ala Asp Gly Thr Leu Ala Glu Leu Lys Ser Glu 1490 1495 1500 Ser Ala Ala Gly Arg Leu Thr Ile Leu Pro Thr Val Ile Ile Val 1505 1510 1515 Asp Ser Thr Val Ala Pro Thr Ala Val Thr Phe Asp Lys Ala Asn 1520 1525 1530 Gln Ala Asp Ala Ala Ile Thr Met Thr Leu Asn Gly Asn Thr Phe 1535 1540 1545 Ser Ala Ile Lys Asn Gly Thr Ala Thr Leu Val Lys Gly Thr Asp 1550 1555 1560 Tyr Thr Val Ser Glu Asn Val Val Thr Ile Ser Lys Ala Tyr Leu 1565 1570 1575 Ala Lys Gln Thr Gly Thr Val Thr Leu Glu Phe Val Phe Asp Lys 1580 1585 1590 Gly Asn Ser Ala Lys Val Val Val Ala Val Lys Glu Ile Gln Ile 1595 1600 1605 Val Asn Ser Thr Ile Thr Pro Val Val Ala Thr Phe Glu Lys Thr 1610 1615 1620 Ala Ala Lys Gln Ala Asp Val Val Val Thr Met Ser Leu Asn Gly 1625 1630 1635 Asn Thr Phe Ser Ala Ile Lys Asn Gly Thr Thr Thr Leu Val Lys 1640 1645 1650 Gly Thr Asp Tyr Thr Ile Ser Gly Ser Thr Val Thr Ile Ser Lys 1655 1660 1665 Ala Tyr Leu Ala Thr Leu Ala Asp Gly Ser Ala Thr Leu Glu Phe 1670 1675 1680 Val Phe Asn Gln Gly Ala Ser Ala Lys Leu Arg Leu Thr Ile Val 1685 1690 1695 Pro Ala Val Val Asp Pro Val Val Thr Asp Phe Ala Val Lys Ile 1700 1705 1710 Asp Lys Val Ser Ala Ala Ala Gly Ser Thr Val Lys Val Pro Val 1715 1720 1725 Ser Leu Ile Asn Val Ser Lys Val Gly Asn Val Cys Val Ala Glu 1730 1735 1740 Tyr Lys Ile Ser Phe Asp Ser Ser Val Leu Thr Tyr Val Gly Thr 1745 1750 1755 Thr Ala Gly Thr Ser Ile Lys Asn Pro Ala Val Asn Phe Ser Ser 1760 1765 1770 Gln Leu Asn Gly Asn Thr Ile Thr Leu Leu Phe Phe Asp Asn Thr 1775 1780 1785 Ile Gly Asn Glu Leu Ile Thr Ala Asp Gly Gln Phe Ala Thr Ile 1790 1795 1800 Glu Phe Lys Val Asn Ala Ala Ala Thr Ser Gly Thr Thr Ala Glu 1805 1810 1815 Val Lys Val Ala Thr Ile Ser Ser Phe Ala Asp Ala Ser Leu Thr 1820 1825 1830 Glu Ile Thr Lys Val Ala Thr Val Asn Gly Ser Val Lys Val Ser 1835 1840 1845 2